A7X8B3
SS
Gene name |
PGR (NR3C3) |
Protein name |
Progesterone receptor |
Names |
PR , Nuclear receptor subfamily 3 group C member 3 |
Species |
Pan troglodytes (Chimpanzee) |
KEGG Pathway |
ptr:451502 |
EC number |
|
Protein Class |
|
Descriptions
Human progesterone receptor A (PR-A) and B (PR-B) isoforms are members of the nuclear receptor family of ligand-activated transcription factors. The two PR proteins are identical except that PR-B contains an additional 164 N-terminal amino acids in the B upstream segment (BUS). <br>In PR-B, the deletion of the autoinhibitory region increases the transcriptional activity. In PR-A, deletion of the same region also increases its transcriptional activity. The autoinhibitory region contains a SUMO-1 binding motif (IKEE) and mutation within the motif leads to loss of autoinhibitory function.
Autoinhibitory domains (AIDs)
Target domain |
687-933 (hormone binding domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for A7X8B3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for A7X8B3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A7X8B3 | |||||
No associated diseases with A7X8B3
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| estrogen response element binding | Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. |
| nuclear receptor activity | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. |
| nuclear steroid receptor activity | Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. |
| steroid binding | Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular steroid hormone receptor signaling pathway | The series of molecular signals initiated by a steroid binding to an intracellular steroid hormone receptor. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
29 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9TTR7 | NR2F2 | COUP transcription factor 2 | Bos taurus (Bovine) | PR |
| O18971 | PPARG | Peroxisome proliferator-activated receptor gamma | Bos taurus (Bovine) | PR |
| Q90733 | NR2F2 | COUP transcription factor 2 | Gallus gallus (Chicken) | PR |
| P68306 | THRB | Thyroid hormone receptor beta | Gallus gallus (Chicken) | PR |
| Q9GLW0 | PGR | Progesterone receptor | Canis lupus familiaris (Dog) (Canis familiaris) | SS |
| P37231 | PPARG | Peroxisome proliferator-activated receptor gamma | Homo sapiens (Human) | PR |
| P10588 | NR2F6 | Nuclear receptor subfamily 2 group F member 6 | Homo sapiens (Human) | PR |
| P10589 | NR2F1 | COUP transcription factor 1 | Homo sapiens (Human) | PR |
| O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (Human) | PR |
| P24468 | NR2F2 | COUP transcription factor 2 | Homo sapiens (Human) | PR |
| P49116 | NR2C2 | Nuclear receptor subfamily 2 group C member 2 | Homo sapiens (Human) | PR |
| P06401 | PGR | Progesterone receptor | Homo sapiens (Human) | EV |
| P35396 | Ppard | Peroxisome proliferator-activated receptor delta | Mus musculus (Mouse) | PR |
| P43136 | Nr2f6 | Nuclear receptor subfamily 2 group F member 6 | Mus musculus (Mouse) | PR |
| P43135 | Nr2f2 | COUP transcription factor 2 | Mus musculus (Mouse) | PR |
| Q9Z0Y9 | Nr1h3 | Oxysterols receptor LXR-alpha | Mus musculus (Mouse) | PR |
| Q00175 | Pgr | Progesterone receptor | Mus musculus (Mouse) | SS |
| O62807 | PPARG | Peroxisome proliferator-activated receptor gamma | Sus scrofa (Pig) | PR |
| O09018 | Nr2f2 | COUP transcription factor 2 | Rattus norvegicus (Rat) | PR |
| Q63449 | Pgr | Progesterone receptor | Rattus norvegicus (Rat) | SS |
| Q8SQ01 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Macaca mulatta (Rhesus macaque) | PR |
| G5EFF5 | daf-12 | Nuclear hormone receptor family member daf-12 | Caenorhabditis elegans | PR |
| O45460 | nhr-54 | Nuclear hormone receptor family member nhr-54 | Caenorhabditis elegans | PR |
| Q20765 | nhr-7 | Nuclear hormone receptor family member nhr-7 | Caenorhabditis elegans | PR |
| Q21006 | nhr-34 | Nuclear hormone receptor family member nhr-34 | Caenorhabditis elegans | PR |
| O17928 | nhr-52 | Nuclear hormone receptor family member nhr-52 | Caenorhabditis elegans | PR |
| Q21878 | nhr-1 | Nuclear hormone receptor family member nhr-1 | Caenorhabditis elegans | PR |
| O18141 | nhr-79 | Nuclear hormone receptor family member nhr-79 | Caenorhabditis elegans | PR |
| Q6PH18 | nr2f1b | Nuclear receptor subfamily 2 group F member 1-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTELKAKGPR | APHVAGGPPS | PEVGSPLLCR | PAAGPFPGSQ | TSDTLPEVSA | IPISLDGLLF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PRPCQGQDPS | NEKTQDQQSL | SDVEGAYSRA | EATRGAGGSS | SSPPEKDSGL | LDSVLDTLLA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSGPGQSQPS | PPACEVTSSW | CLFGPELPED | PPAAPATQGV | LSPLMSRSGC | KAGDSSGTAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AHKVLPRGLS | PSRQLLLPAS | GSPHWSGAPV | KPSPQPAAVE | VEEEDGSESE | ESAGPLLKGK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PRALGGAAAG | GGAAAVPPGA | AAGGVALVPK | EDSRFSAPRV | ALVEQDAPMA | PXRSPLATTM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MDFIHVPILP | LNHALLAART | RQLLEDESYD | GGAGAXSAFA | PPRSSPSASS | TPVAVGDFPD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| CAYPPDAEPK | DDAYPLYSDF | QPPALKIKEE | EEGAEASARS | PRSYLVAGAN | PAAFPDFPLG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPPPLPPRAP | PSRPGEAAVT | AAPASASVSS | ASSSGSTLEC | ILYKAEGAPP | QQGPFAPPPC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KAPGASGCLL | PRDGLPSTSA | SAAAAGAAPA | LYPALGLNGL | PQLGYQAAVL | KEGLPQVYPP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YLNYLRPDSE | ASQSPQYSFE | SLPQKICLIC | GDEASGCHYG | VLTCGSCKVF | FKRAMEGQHN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| YLCAGRNDCI | VDKIRRKNCP | ACRLRKCCQA | GMVLGGRKFK | KFNKVRVVRA | LDAVALPQPV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GIPNESQALS | QRFTFSPGQD | IQLIPPLINL | LMSIEPDVIY | AGHDNTKPDT | SSSLLTSLNQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LGERQLLSVV | KWSKSLPGFR | NLHIDDQITL | IQYSWMSLMV | FGLGWRSYKH | VSGQMLYFAP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DLILNEQRMK | ESSFYSLCLT | MWQIPQEFVK | LQVSQEEFLC | MKVLLLLNTI | PLEGLRSQTQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FEEMRSSYIR | ELIKAIGLRQ | KGVVSSSQRF | YQLTKLLDNL | HDLVKQLHLY | CLNTFIQSRA |
| 910 | 920 | 930 | |||
| LSVEFPEMMS | EVIAAQLPKI | LAGMVKPLLF | HKK |