A7MBI0

SS
Gene name
PACSIN1
Protein name
Protein kinase C and casein kinase substrate in neurons protein 1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:520488
EC number
Protein Class

Descriptions

The F-BAR domain-containing protein PACSIN contributes to the vesicle formation at plasma membrane and has been shown to induce a spectrum of membrane morphologies including tubules and tube constrictions. In a study with a human homolog PACSIN1 (Q9BY11), full-length PACSIN1 has reduced activity compared with its isolated F-BAR domain. The autoinhibition is mediated by the SH3 domain interacting with F-BAR domain in PACSIN1. The SH3 domain is able to bind the proline-rich domain (PRD) of proteins in endocytosis. THe interaction between the SH3 and the PRD in other proteins relieve the intramolecular autoinhibition.

Autoinhibitory domains (AIDs)

386-444 (SH3 domain) SS

Target domain

13-283 (F-BAR domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7MBI0

Entry ID Method Resolution Chain Position Source
AF-A7MBI0-F1 Predicted AlphaFoldDB

148 variants for A7MBI0

Variant ID(s) Position Change Description Diseaes Association Provenance
rs468119601 22 V>G No Ensembl
rs435238307 24 N>K No Ensembl
rs435238307 24 N>K No Ensembl
rs136809601 25 Y>N No Ensembl
rs454225502 29 V>G No Ensembl
rs433331462 44 S>R No Ensembl
rs476911081 46 V>G No Ensembl
rs451913688 46 V>L No Ensembl
rs443661418 47 Q>E No Ensembl
rs455713849 48 E>G No Ensembl
rs474322580 49 R>G No Ensembl
rs441335945 52 I>T No Ensembl
rs460394556 54 K>N No Ensembl
rs478857379 55 A>P No Ensembl
rs449625104 59 Q>H No Ensembl
rs482689295 59 Q>P No Ensembl
rs468006762 60 L>V No Ensembl
rs447313028 63 W>* No Ensembl
rs465833823 64 A>P No Ensembl
rs433394466 67 W>* No Ensembl
rs433394466 67 W>C No Ensembl
rs136412528 69 Q>H No Ensembl
rs451846365 71 L>R No Ensembl
rs475524853 75 P>L No Ensembl
rs461580678 83 A>D No Ensembl
rs480055174 92 D>E No Ensembl
rs440566720 97 L>Q No Ensembl
rs459266244 98 H>Q No Ensembl
rs477741385 99 Q>H No Ensembl
rs450828090 105 L>Q No Ensembl
rs481363649 109 D>E No Ensembl
rs466984220 120 A>P No Ensembl
rs434602613 120 A>V No Ensembl
rs480507484 142 A>V No Ensembl
rs465302169 143 Q>* No Ensembl
rs432222917 146 W>G No Ensembl
rs435930095 152 E>G No Ensembl
rs475387711 152 E>K No Ensembl
rs462202435 153 L>I No Ensembl
rs481280724 154 E>K No Ensembl
rs460417392 155 A>G No Ensembl
rs441779297 155 A>S No Ensembl
rs463987507 156 A>D No Ensembl
rs445617633 156 A>P No Ensembl
rs449700538 157 K>E No Ensembl
rs468058351 157 K>N No Ensembl
rs435803681 158 K>* No Ensembl
rs466454078 163 A>P No Ensembl
rs451763846 164 C>G No Ensembl
rs476615254 164 C>Y No Ensembl
rs455852980 170 A>T No Ensembl
rs474288851 172 T>P No Ensembl
rs441825530 175 M>V No Ensembl
rs460329153 176 N>K No Ensembl
rs472524266 177 S>R No Ensembl
rs439454827 179 T>A No Ensembl
rs457838126 187 Q>E No Ensembl
rs211170236 237 F>S No Ensembl
rs466375357 247 E>G No Ensembl
rs433335256 248 V>G No Ensembl
rs445567389 250 L>P No Ensembl
rs437210710 251 D>G No Ensembl
rs455711577 255 H>Y No Ensembl
rs474334217 257 N>S No Ensembl
rs434871303 260 E>G No Ensembl
rs457049564 271 L>Q No Ensembl
rs443044187 274 A>D No Ensembl
rs473768115 275 I>S No Ensembl
rs473768115 275 I>T No Ensembl
rs440703657 276 R>G No Ensembl
rs459035237 277 G>E No Ensembl
rs477231413 278 A>T No Ensembl
rs450766998 278 A>V No Ensembl
rs462924548 279 D>E No Ensembl
rs481556059 280 A>P No Ensembl
rs449119167 282 D>A No Ensembl
rs467530701 283 D>A No Ensembl
rs467530701 283 D>G No Ensembl
rs434537389 286 W>R No Ensembl
rs446764961 287 F>S No Ensembl
rs431966462 288 R>P No Ensembl
rs465234467 288 R>S No Ensembl
rs475572695 289 S>R No Ensembl
rs436077660 290 T>P No Ensembl
rs454573309 291 S>G No Ensembl
rs473599352 291 S>I No Ensembl
rs440560214 291 S>R No Ensembl
rs459100309 292 G>A No Ensembl
rs459100309 292 G>D No Ensembl
rs471095091 294 G>C No Ensembl
rs462782010 295 M>I No Ensembl
rs444428595 295 M>L No Ensembl
rs442100533 297 M>K No Ensembl
rs481604177 297 M>V No Ensembl
rs460605050 299 W>C No Ensembl
rs479677241 301 Q>H No Ensembl
rs450824820 304 E>G No Ensembl
rs477159342 304 E>Q No Ensembl
rs469276206 305 W>G No Ensembl
rs481094778 306 N>D No Ensembl
rs481094778 306 N>Y No Ensembl
rs448051327 307 P>S No Ensembl
rs466658796 308 D>H No Ensembl
rs433650875 312 T>S No Ensembl
rs452632518 313 A>T No Ensembl
rs438108861 316 K>R No Ensembl
rs456796535 319 Q>* No Ensembl
rs475302972 321 K>E No Ensembl
rs442027867 322 K>* No Ensembl
rs454079665 333 G>A No Ensembl
rs454079665 333 G>V No Ensembl
rs439721211 334 V>A No Ensembl
rs439721211 334 V>E No Ensembl
rs458186008 335 V>A No Ensembl
rs458186008 335 V>G No Ensembl
rs444210800 336 E>A No Ensembl
rs462844014 336 E>D No Ensembl
rs470806302 336 E>Q No Ensembl
rs481343954 338 T>A No Ensembl
rs448037548 338 T>K No Ensembl
rs481343954 338 T>P No Ensembl
rs481343954 338 T>S No Ensembl
rs460144895 339 S>T No Ensembl
rs478373908 341 A>D No Ensembl
rs445706877 342 G>W No Ensembl
rs438172095 343 D>E No Ensembl
rs438172095 343 D>E No Ensembl
rs464061199 343 D>Y No Ensembl
rs450247328 345 G>D No Ensembl
rs464094176 347 V>A No Ensembl
rs449313332 351 D>H No Ensembl
rs461295136 352 R>G No Ensembl
rs461295136 352 R>W No Ensembl
rs479573775 353 G>S No Ensembl
rs465270311 357 A>D No Ensembl
rs432981606 372 S>R No Ensembl
rs444972337 382 D>V No Ensembl
rs470146748 387 G>R No Ensembl
rs437070914 394 Y>N No Ensembl
rs455583506 397 D>H No Ensembl
rs473807684 400 E>D No Ensembl
rs434341603 403 E>* No Ensembl
rs471474418 406 F>L No Ensembl
rs453042435 406 F>S No Ensembl
rs453042435 406 F>Y No Ensembl
rs439049239 407 K>M No Ensembl
rs463918260 407 K>N No Ensembl
rs458802700 424 C>W No Ensembl

No associated diseases with A7MBI0

No regional properties for A7MBI0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A7MBI0

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell projection
  • Synapse, synaptosome
  • Cell projection, ruffle membrane
  • Membrane ; Peripheral membrane protein
  • Cytoplasmic vesicle membrane ; Peripheral membrane protein
  • Synapse
  • Cytoplasm, cytosol
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Colocalizes with MAPT in axons
  • In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body
  • Colocalizes with DNM1 at vesicular structures in the cell body and neurites
  • Associates with membranes via its F-BAR domain (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
axon terminus Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endosome A vacuole to which materials ingested by endocytosis are delivered.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
ruffle membrane The portion of the plasma membrane surrounding a ruffle.

1 GO annotations of molecular function

Name Definition
phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.

8 GO annotations of biological process

Name Definition
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
plasma membrane tubulation A membrane tubulation process occurring in a plasma membrane.
positive regulation of dendrite development Any process that activates or increases the frequency, rate or extent of dendrite development.
protein localization to membrane A process in which a protein is transported to, or maintained in, a specific location in a membrane.
regulation of endocytosis Any process that modulates the frequency, rate or extent of endocytosis.
synaptic vesicle endocytosis A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P25623 SYP1 Suppressor of yeast profilin deletion Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O13154 PACSIN2 Protein kinase C and casein kinase substrate in neurons protein 2 Gallus gallus (Chicken) SS
Q9UKS6 PACSIN3 Protein kinase C and casein kinase substrate in neurons protein 3 Homo sapiens (Human) SS
Q9UNF0 PACSIN2 Protein kinase C and casein kinase substrate in neurons protein 2 Homo sapiens (Human) EV
Q9BY11 PACSIN1 Protein kinase C and casein kinase substrate in neurons protein 1 Homo sapiens (Human) EV
Q9H939 PSTPIP2 Proline-serine-threonine phosphatase-interacting protein 2 Homo sapiens (Human) PR
Q99JB8 Pacsin3 Protein kinase C and casein kinase II substrate protein 3 Mus musculus (Mouse) SS
Q9WVE8 Pacsin2 Protein kinase C and casein kinase substrate in neurons protein 2 Mus musculus (Mouse) EV
Q61644 Pacsin1 Protein kinase C and casein kinase substrate in neurons protein 1 Mus musculus (Mouse) EV
Q99M15 Pstpip2 Proline-serine-threonine phosphatase-interacting protein 2 Mus musculus (Mouse) PR
Q9QY17 Pacsin2 Protein kinase C and casein kinase substrate in neurons 2 protein Rattus norvegicus (Rat) SS
Q9Z0W5 Pacsin1 Protein kinase C and casein kinase substrate in neurons protein 1 Rattus norvegicus (Rat) SS
Q4V920 pacsin1b Protein kinase C and casein kinase substrate in neurons protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MSGSYDEASL APEETTDSFW EVGNYKRTVK RIDDGHRLCN DLMSCVQERA KIEKAYAQQL
70 80 90 100 110 120
TDWAKRWRQL LEKGPQYGSL ERAWGAIMTE ADKVSELHQE MKNSLLNEDL EKVKNWQKDA
130 140 150 160 170 180
YHKQIMGGFK ETKEAEDGFR KAQKPWAKKM KELEAAKKAY HLACKEEKLA VTREMNSKTE
190 200 210 220 230 240
QSVTPEQQKK LQDKVDKCKQ DVQKTQEKYE KVLDDVGKTT PQYMEGMEQV FEQCQQFEEK
250 260 270 280 290 300
RLVFLKEVLL DIKRHLNLAE SSSYVQVYRE LEQAIRGADA QDDLRWFRST SGPGMPMNWP
310 320 330 340 350 360
QFEEWNPDLP HTAAKKEKQP KKAEGAALTN AAGVVESTSQ AGDRGSVSSY DRGQTYATEW
370 380 390 400 410 420
SDDESGNPFG GSEANGGSNP FDEDAKGVRV RALYDYDGQE QDELSFKAGD ELTKLGEEDE
430 440
QGWCRGRLDS GQLGLYPANY VEVV