AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

375-425 (SH3 domain) SS

Target domain	1-244 (TPR repeats and activation domain)
Relief mechanism	Partner binding
Assay

375-425 (SH3 domain)

1-244 (TPR repeats and activation domain)

Partner binding (Interaction of SH3 domain with N-src)

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-A7E3N7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for A7E3N7

Type	Name	Position	InterPro Accession
domain	Pleckstrin homology domain	350 - 455	IPR001849
domain	FERM central domain	263 - 555	IPR019748
domain	Band 4.1 domain	94 - 556	IPR019749
domain	Kindlin/fermitin, PH domain	350 - 474	IPR037837
domain	Kindlin-2, N-terminal	11 - 98	IPR040790

		Description
EC Number
Subcellular Localization	Cytoplasm Cell membrane	Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
NADPH oxidase complex	A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2.

Name	Definition
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
SH3 domain binding	Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
small GTPase binding	Binding to a small monomeric GTPase.
superoxide-generating NADPH oxidase activator activity	Binds to and increases the activity of the enzyme superoxide-generating NADPH oxidase.

Name	Definition
regulation of hydrogen peroxide metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide.
regulation of respiratory burst	Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.
superoxide anion generation	The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.
superoxide metabolic process	The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O77775	NCF2	Neutrophil cytosol factor 2	Bos taurus (Bovine)	PR
Q5HYK7	SH3D19	SH3 domain-containing protein 19	Homo sapiens (Human)	PR
Q6XZF7	DNMBP	Dynamin-binding protein	Homo sapiens (Human)	PR
P19878	NCF2	Neutrophil cytosol factor 2	Homo sapiens (Human)	PR
Q86UR1	NOXA1	NADPH oxidase activator 1	Homo sapiens (Human)	EV
O70145	Ncf2	Neutrophil cytosol factor 2	Mus musculus (Mouse)	PR
Q8CJ00	Noxa1	NADPH oxidase activator 1	Mus musculus (Mouse)	SS
A7E3N2	Ncf2	Neutrophil cytosol factor 2	Rattus norvegicus (Rat)	PR