A6QQ71
PR
Gene name |
FKBP6 (FKBP36) |
Protein name |
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 |
Names |
Inactive PPIase FKBP6, 36 kDa FK506-binding protein, FK506-binding protein 6, FKBP-6, Immunophilin FKBP36 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:537921 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6QQ71
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6QQ71-F1 | Predicted | AlphaFoldDB |
34 variants for A6QQ71
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs437449527 | 2 | S>G | No | EVA | |
| rs437449527 | 2 | S>R | No | EVA | |
| rs476942179 | 3 | S>T | No | EVA | |
| rs451673005 | 6 | P>R | No | EVA | |
| rs433215605 | 9 | G>* | No | EVA | |
| rs433215605 | 9 | G>R | No | EVA | |
| rs447718416 | 10 | L>F | No | EVA | |
| rs466270995 | 10 | L>M | No | EVA | |
| rs435677470 | 13 | L>V | No | EVA | |
| rs467368115 | 15 | A>E | No | EVA | |
| rs481877634 | 17 | D>A | No | EVA | |
| rs481877634 | 17 | D>G | No | EVA | |
| rs463667539 | 18 | R>Q | No | EVA | |
| rs456388244 | 22 | Q>R | No | EVA | |
| rs444448228 | 25 | S>G | No | EVA | |
| rs451389922 | 33 | G>R | No | EVA | |
| rs433010475 | 36 | G>V | No | EVA | |
| rs454052626 | 37 | V>G | No | EVA | |
| rs468136580 | 48 | E>D | No | EVA | |
| rs449673975 | 49 | L>R | No | EVA | |
| rs482742327 | 51 | T>P | No | EVA | |
| rs465430103 | 87 | E>D | No | EVA | |
| rs455708287 | 96 | L>R | No | EVA | |
| rs437212020 | 97 | G>R | No | EVA | |
| rs470275747 | 100 | S>N | No | EVA | |
| rs445263389 | 105 | E>* | No | EVA | |
| rs464955739 | 130 | T>S | No | EVA | |
| rs433284244 | 130 | T>S | No | EVA | |
| rs479512680 | 139 | L>H | No | EVA | |
| rs461121874 | 140 | D>G | No | EVA | |
| rs465387311 | 196 | A>S | No | EVA | |
| rs446930620 | 202 | R>Q | No | EVA | |
| rs479920919 | 205 | A>S | No | EVA | |
| rs382537346 | 300 | R>M | No | EVA |
No associated diseases with A6QQ71
4 regional properties for A6QQ71
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FKBP-type peptidyl-prolyl cis-trans isomerase domain | 51 - 142 | IPR001179 |
| repeat | Tetratricopeptide repeat | 170 - 203 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 218 - 251 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 252 - 285 | IPR019734-3 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| synaptonemal complex | A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| Hsp90 protein binding | Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. |
| identical protein binding | Binding to an identical protein or proteins. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| DNA methylation involved in gamete generation | The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete. |
| gene silencing by RNA | A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| piRNA metabolic process | The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. |
| positive regulation of viral genome replication | Any process that activates or increases the frequency, rate or extent of viral genome replication. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9W1I9 | shu | Inactive peptidyl-prolyl cis-trans isomerase shutdown | Drosophila melanogaster (Fruit fly) | PR |
| F6PHZ6 | FKBP6 | Inactive peptidyl-prolyl cis-trans isomerase FKBP6 | Equus caballus (Horse) | PR |
| Q14318 | FKBP8 | Peptidyl-prolyl cis-trans isomerase FKBP8 | Homo sapiens (Human) | EV |
| Q02790 | FKBP4 | Peptidyl-prolyl cis-trans isomerase FKBP4 | Homo sapiens (Human) | PR |
| O35465 | Fkbp8 | Peptidyl-prolyl cis-trans isomerase FKBP8 | Mus musculus (Mouse) | SS |
| Q3B7U9 | Fkbp8 | Peptidyl-prolyl cis-trans isomerase FKBP8 | Rattus norvegicus (Rat) | SS |
| Q7DMA9 | PAS1 | Peptidyl-prolyl cis-trans isomerase PASTICCINO1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSSRPLNGL | SRLDAEDRSP | YQRLSQRMLD | ISGDRGVLKD | VIREGAGELV | TPDASVLVKY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SGYLEHMDKP | FDSNCFRKTP | RLMKLGEDIT | LWGMELGLLS | MRRGELARFL | FKPTYAYGTL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GCPPLIPPNT | TVLFEIELLD | FLDSAESDKF | CALSAEQQSQ | FPLQKVLKVA | ATEREFGNYL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FRQNRFYDAK | VRYKRALLLL | HRRTAPPEEQ | HLVETAKLLV | FLNLSFTYLK | LERPTMALRY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GEQALIIDRK | NAKALFRCGQ | ACLLMTEYQK | ARDFLVRAQR | EQPFNHDINN | ELKKLASYYR |
| 310 | 320 | ||||
| DYMDKEREMC | HRMFASGDNG | STVGEN |