Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for A6NCK2

Entry ID Method Resolution Chain Position Source
AF-A6NCK2-F1 Predicted AlphaFoldDB

182 variants for A6NCK2

Variant ID(s) Position Change Description Diseaes Association Provenance
CA1772921
rs536256473
2 D>N No ClinGen
1000Genomes
ExAC
gnomAD
rs376058095
CA1772920
6 S>P No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA1772918
rs752660513
8 A>D No ClinGen
ExAC
TOPMed
gnomAD
CA427623420
rs752660513
8 A>V No ClinGen
ExAC
TOPMed
gnomAD
rs199943409
CA52234851
14 T>I No ClinGen
ExAC
TOPMed
gnomAD
rs199943409
CA1772915
14 T>S No ClinGen
ExAC
TOPMed
gnomAD
CA427623240
rs1862895
15 C>W No ClinGen
ExAC
TOPMed
gnomAD
rs1327721229
CA427623253
15 C>Y No ClinGen
TOPMed
gnomAD
CA1772912
rs375271552
17 I>F No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA1772911
rs375271552
17 I>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1415564699
CA427623140
19 L>F No ClinGen
gnomAD
CA427623051
rs1480818131
23 V>E No ClinGen
gnomAD
CA1772908
rs769206493
25 P>A No ClinGen
ExAC
gnomAD
CA427622996
rs1208542086
25 P>L No ClinGen
TOPMed
CA1772907
rs769206493
25 P>S No ClinGen
ExAC
gnomAD
rs13000235
CA52234839
30 C>W No ClinGen
Ensembl
CA427622834
rs756253345
32 H>P No ClinGen
ExAC
TOPMed
gnomAD
CA1772904
rs756253345
32 H>R No ClinGen
ExAC
TOPMed
gnomAD
rs1213131669
CA427622811
33 S>N No ClinGen
TOPMed
gnomAD
rs746128185
CA1772903
35 C>Y No ClinGen
ExAC
TOPMed
gnomAD
rs1469203496
CA427622729
36 R>K No ClinGen
TOPMed
CA1772902
rs781322919
36 R>W No ClinGen
ExAC
gnomAD
rs752607296
CA1772900
37 P>H No ClinGen
ExAC
gnomAD
CA427622705
rs752607296
37 P>L No ClinGen
ExAC
gnomAD
rs758238462
CA1772901
37 P>S No ClinGen
ExAC
gnomAD
rs917384450
CA52234831
39 L>R No ClinGen
TOPMed
CA1772898
rs1205005952
40 C>F No ClinGen
gnomAD
rs1439489276
CA427622615
41 L>V No ClinGen
gnomAD
CA1772896
rs369206903
42 S>* No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs369206903
CA1772895
42 S>L No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA427622546
rs1460443980
43 W>C No ClinGen
TOPMed
gnomAD
CA427622490
rs1161147932
46 A>T No ClinGen
gnomAD
CA427622478
rs1419474526
46 A>V No ClinGen
gnomAD
CA1772893
rs551182192
49 P>L No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA427622393
rs1455793825
50 A>T No ClinGen
gnomAD
rs984809358
CA52234819
53 P>S No ClinGen
TOPMed
rs1437332018
CA427622298
54 A>T No ClinGen
TOPMed
CA52234814
rs1028681429
54 A>V No ClinGen
TOPMed
gnomAD
rs1283235465
CA427622271
55 C>G No ClinGen
gnomAD
CA427622268
rs1233858346
55 C>Y No ClinGen
TOPMed
CA427622227
rs772886426
57 E>K No ClinGen
ExAC
gnomAD
rs772886426
CA1772892
57 E>Q No ClinGen
ExAC
gnomAD
rs1445551621
CA427622192
58 P>L No ClinGen
TOPMed
gnomAD
rs1270859796
CA427622173
59 S>L No ClinGen
TOPMed
rs774708680
CA1772889
60 P>L No ClinGen
ExAC
gnomAD
CA427622157
rs1316703340
60 P>S No ClinGen
gnomAD
CA1772888
rs769087749
62 M>T No ClinGen
ExAC
gnomAD
TCGA novel 67 N>Y Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA427621935
rs1303651395
69 L>I No ClinGen
gnomAD
rs1368082864
CA427621896
70 L>P No ClinGen
gnomAD
rs528245128
CA1772887
71 K>M No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
TCGA novel 73 L>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs775387040
CA427621764
75 T>I No ClinGen
ExAC
TOPMed
gnomAD
rs775387040
CA1772886
75 T>N No ClinGen
ExAC
TOPMed
gnomAD
CA1772885
rs769898750
77 A>T No ClinGen
ExAC
gnomAD
rs1436323582
CA427621712
77 A>V No ClinGen
TOPMed
gnomAD
CA52234803
rs901585249
80 A>V No ClinGen
TOPMed
CA427621584
rs1161536023
82 L>P No ClinGen
TOPMed
gnomAD
rs1019149050
CA52234801
83 W>R No ClinGen
TOPMed
CA427621402
rs1413351582
91 Q>E No ClinGen
gnomAD
rs1240839834
CA427621377
92 I>T No ClinGen
gnomAD
CA1772881
rs542608231
93 C>G No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs542608231
CA427621360
93 C>R No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs542608231
CA427621358
93 C>S No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1473989778
CA427621354
93 C>Y No ClinGen
gnomAD
rs200840140
CA1772880
94 G>W No ClinGen
ExAC
TOPMed
gnomAD
rs1463971224
CA427621211
99 T>I No ClinGen
gnomAD
rs1297179014
CA427621188
100 K>R No ClinGen
gnomAD
rs1382279215
CA427621156
101 K>N No ClinGen
gnomAD
rs1365637524
CA427621054
106 M>V No ClinGen
TOPMed
CA1772876
rs753791053
107 D>N No ClinGen
ExAC
gnomAD
CA427620956
rs1173254528
110 L>I Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
rs561398896
CA1772874
112 C>R No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA52234788
rs905830016
112 C>Y No ClinGen
TOPMed
rs1291321331
CA427620919
113 L>F No ClinGen
TOPMed
CA427620915
rs1374990958
114 L>V No ClinGen
gnomAD
rs1210128649
CA427620884
115 C>Y No ClinGen
gnomAD
CA427620839
rs1427958437
117 N>K No ClinGen
gnomAD
CA427620834
rs1418030523
118 S>Y No ClinGen
gnomAD
CA427620816
rs1190636376
120 E>* No ClinGen
gnomAD
TCGA novel 120 E>D Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1486209072
CA427620809
121 H>Y No ClinGen
gnomAD
CA1772873
rs755640959
CA427620800
122 G>R No ClinGen
ExAC
TOPMed
gnomAD
CA427620792
rs1482103113
123 A>T No ClinGen
gnomAD
CA1772871
rs544922225
125 K>E No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA1772870
rs767095882
127 Y>H No ClinGen
ExAC
TOPMed
gnomAD
CA1772868
rs371134371
128 P>A No ClinGen
ExAC
gnomAD
CA1772867
rs764468196
128 P>L No ClinGen
ExAC
TOPMed
gnomAD
rs371134371
CA1772869
128 P>S No ClinGen
ExAC
gnomAD
rs763279378
CA427620737
129 I>M No ClinGen
ExAC
TOPMed
gnomAD
rs1398957418
CA427620742
129 I>V No ClinGen
gnomAD
rs575739368
CA1772864
130 E>K No ClinGen
1000Genomes
ExAC
gnomAD
rs575739368
CA1772865
130 E>Q No ClinGen
1000Genomes
ExAC
gnomAD
CA1772862
rs559151097
131 E>G No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA1772863
rs759648985
131 E>K No ClinGen
ExAC
gnomAD
rs771213408
CA1772861
132 A>T No ClinGen
ExAC
TOPMed
gnomAD
rs1363028068
CA427620694
135 E>K No ClinGen
gnomAD
CA427620691
rs1421211052
135 E>V No ClinGen
gnomAD
CA1772859
rs778188224
136 D>G No ClinGen
ExAC
TOPMed
gnomAD
CA427620686
rs1252264106
136 D>H No ClinGen
TOPMed
gnomAD
CA427620677
rs114549087
137 R>P No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
CA1772858
rs114549087
137 R>Q No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs545199654
CA52234774
137 R>W No ClinGen
1000Genomes
TOPMed
gnomAD
CA1772827
rs765554119
140 L>F No ClinGen
ExAC
TOPMed
gnomAD
CA427620615
rs1262313218
140 L>H No ClinGen
TOPMed
gnomAD
rs932792632
CA52234645
143 Q>* No ClinGen
TOPMed
TCGA novel 144 M>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs921443630
CA52234643
148 W>R No ClinGen
TOPMed
CA427620506
rs1303820414
150 K>E No ClinGen
TOPMed
rs1235217499
CA427620490
151 I>F No ClinGen
TOPMed
gnomAD
CA1772826
rs574055938
151 I>S No ClinGen
ExAC
TOPMed
gnomAD
CA1772825
rs368669319
153 E>K No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs767059540
CA1772824
154 N>D No ClinGen
ExAC
TOPMed
gnomAD
TCGA novel 155 Q>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1229001438
CA427620433
156 R>I No ClinGen
gnomAD
CA1772822
rs773434974
159 Y>H No ClinGen
ExAC
TOPMed
gnomAD
rs761970818
CA1772820
161 E>V No ClinGen
ExAC
gnomAD
rs769456796
CA1772818
162 R>G No ClinGen
ExAC
TOPMed
gnomAD
rs373596756
CA1772816
163 R>K No ClinGen
ESP
ExAC
gnomAD
CA52234628
rs911525586
164 T>K No ClinGen
TOPMed
rs911525586
CA427620367
164 T>R No ClinGen
TOPMed
CA1772814
rs776550245
165 A>T No ClinGen
ExAC
gnomAD
CA1772813
rs770913548
166 F>C No ClinGen
ExAC
gnomAD
CA1772811
rs199682241
166 F>L No ClinGen
ExAC
TOPMed
gnomAD
rs747731168
CA427620334
168 L>F No ClinGen
ExAC
gnomAD
rs201662353
CA1772810
168 L>W No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs549632893 170 G>= Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
rs750875154
CA1772785
171 D>N No ClinGen
ExAC
TOPMed
gnomAD
rs1469847259
CA427620311
171 D>V No ClinGen
gnomAD
rs1274373666
CA427620303
172 V>A No ClinGen
gnomAD
rs1213544565
CA427620298
173 V>I No ClinGen
gnomAD
CA1772782
rs1481967811
174 L>F No ClinGen
TOPMed
gnomAD
rs781744171
CA427620243
175 R>G No ClinGen
ExAC
TOPMed
gnomAD
CA427620236
rs539398172
175 R>P No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs539398172
CA1772780
175 R>Q No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs781744171
CA1772781
175 R>W No ClinGen
ExAC
TOPMed
gnomAD
CA427620214
rs1373663525
176 A>E No ClinGen
gnomAD
rs1224663887
CA427620222
176 A>T No ClinGen
gnomAD
rs570148739
CA1772779
178 M>I No ClinGen
1000Genomes
ExAC
gnomAD
rs763170442
CA1772777
180 R>G No ClinGen
ExAC
TOPMed
gnomAD
rs1276407401
CA427620098
181 N>S No ClinGen
TOPMed
gnomAD
CA1772776
rs753593295
182 E>* No ClinGen
ExAC
TOPMed
gnomAD
CA427620084
rs753593295
182 E>Q No ClinGen
ExAC
TOPMed
gnomAD
CA52234452
rs528807377
184 R>G No ClinGen
1000Genomes
gnomAD
CA1772775
rs559624347
188 P>L No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA427619947
rs1348031347
188 P>S No ClinGen
gnomAD
rs761165896
CA1772771
200 R>T No ClinGen
ExAC
rs1326284738
CA427619550
205 Y>C No ClinGen
TOPMed
CA427619558
rs1408192244
205 Y>H No ClinGen
TOPMed
gnomAD
rs1434181201
CA427619533
206 Q>E No ClinGen
TOPMed
CA427619489
rs1274224980
207 E>D No ClinGen
TOPMed
CA52234444
rs549517427
207 E>K No ClinGen
1000Genomes
CA427619479
rs1487820476
208 I>F No ClinGen
gnomAD
rs1362033612
CA427619473
208 I>T No ClinGen
TOPMed
CA1772769
rs529482281
209 F>C No ClinGen
1000Genomes
ExAC
gnomAD
rs773916265
CA1772770
209 F>L No ClinGen
ExAC
TOPMed
gnomAD
CA1772768
rs748970463
210 Q>* No ClinGen
ExAC
gnomAD
rs1255622485
CA427619380
212 L>F No ClinGen
TOPMed
CA1772766
rs563777718
215 S>N No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1275389887
CA427619270
216 W>C No ClinGen
TOPMed
rs1218104095
CA427619208
219 M>T No ClinGen
gnomAD
TCGA novel 221 Q>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1558813563
CA427619151
222 K>N No ClinGen
Ensembl
TCGA novel 224 K>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs781537876
CA1772760
225 H>R No ClinGen
ExAC
gnomAD
CA427619128
rs1359595461
225 H>Y No ClinGen
gnomAD
CA1772759
rs543584416
227 K>* No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA427619102
rs1395898279
228 E>* Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA427619104
rs1395898279
228 E>K No ClinGen
gnomAD
rs1175502009
CA427619057
230 Y>C No ClinGen
TOPMed
gnomAD
rs1431474302
CA427619015
232 E>Q No ClinGen
gnomAD
CA1772758
rs751531671
233 L>V No ClinGen
ExAC
gnomAD
CA1772757
rs577958837
236 M>V No ClinGen
1000Genomes
ExAC
gnomAD
CA1772756
rs758572985
237 C>* No ClinGen
ExAC
TOPMed
gnomAD
rs370477305
CA1772755
238 H>R No ClinGen
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs765508068
CA1772754
240 P>Q No ClinGen
ExAC
gnomAD
CA427618835
rs1213444592
240 P>S No ClinGen
gnomAD
CA1772753
rs370698848
241 E>D No ClinGen
ExAC
TOPMed
gnomAD
CA427618790
rs750242500
242 V>L No ClinGen
ExAC
TOPMed
gnomAD
CA1772752
rs750242500
242 V>M No ClinGen
ExAC
TOPMed
gnomAD
rs1403462390
CA427618738
244 L>P No ClinGen
TOPMed
CA427618726
rs1309883091
245 L>F No ClinGen
gnomAD

No associated diseases with A6NCK2

9 regional properties for A6NCK2

Type Name Position InterPro Accession
domain B-box-type zinc finger 88 - 129 IPR000315
domain Zinc finger, RING-type 15 - 56 IPR001841
domain B30.2/SPRY domain 269 - 446 IPR001870
domain SPRY domain 334 - 446 IPR003877
domain Butyrophylin-like, SPRY domain 319 - 343 IPR003879-1
domain Butyrophylin-like, SPRY domain 349 - 362 IPR003879-2
domain Butyrophylin-like, SPRY domain 394 - 418 IPR003879-3
domain Butyrophylin-like, SPRY domain 425 - 443 IPR003879-4
conserved_site Zinc finger, RING-type, conserved site 30 - 39 IPR017907

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
zinc ion binding Binding to a zinc ion (Zn).

3 GO annotations of biological process

Name Definition
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.
regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9H2S5 RNF39 RING finger protein 39 Homo sapiens (Human) PR
Q86UV7 TRIM73 Tripartite motif-containing protein 73 Homo sapiens (Human) PR
Q86XT4 TRIM50 E3 ubiquitin-protein ligase TRIM50 Homo sapiens (Human) PR
Q6ZMU5 TRIM72 Tripartite motif-containing protein 72 Homo sapiens (Human) PR
Q9UPQ4 TRIM35 E3 ubiquitin-protein ligase TRIM35 Homo sapiens (Human) PR
Q9BZY9 TRIM31 E3 ubiquitin-protein ligase TRIM31 Homo sapiens (Human) PR
Q9C029 TRIM7 E3 ubiquitin-protein ligase TRIM7 Homo sapiens (Human) PR
O15553 MEFV Pyrin Homo sapiens (Human) SS
Q8N9V2 TRIML1 Probable E3 ubiquitin-protein ligase TRIML1 Homo sapiens (Human) PR
P19474 TRIM21 E3 ubiquitin-protein ligase TRIM21 Homo sapiens (Human) PR
Q14142 TRIM14 Tripartite motif-containing protein 14 Homo sapiens (Human) PR
A6NK02 TRIM75 Tripartite motif-containing protein 75 Homo sapiens (Human) PR
Q5EBN2 TRIM61 Putative tripartite motif-containing protein 61 Homo sapiens (Human) PR
Q3TL54 Trim43a Tripartite motif-containing protein 43A Mus musculus (Mouse) PR
P86449 Trim43c Tripartite motif-containing protein 43C Mus musculus (Mouse) PR
10 20 30 40 50 60
MDSDFSHAFQ KELTCVICLN YLVDPVTICC GHSFCRPCLC LSWEEAQSPA NCPACREPSP
70 80 90 100 110 120
KMDFKTNILL KNLVTIARKA SLWQFLSSEK QICGTHRQTK KMFCDMDKSL LCLLCSNSQE
130 140 150 160 170 180
HGAHKHYPIE EAAEEDREKL LKQMRILWKK IQENQRNLYE ERRTAFLLRG DVVLRAQMIR
190 200 210 220 230 240
NEYRKLHPVL HKEEKQHLER LNKEYQEIFQ QLQRSWVKMD QKSKHLKEMY QELMEMCHKP
250 260 270 280 290 300
EVELLQDLGD IVARSESVLL HMPQPVNPEL TAGPITGLVY RLNRFRVEIS FHFEVTNHNI
310 320 330 340 350 360
RLFEDVRSWM FRRGPLNSDR SDYFAAWGAR VFSFGKHYWE LDVDNSCDWA LGVCNNSWIR
370 380 390 400 410 420
KNSTMVNSED IFLLLCLKVD NHFNLLTTSP VFPHYIEKPL GRVGVFLDFE SGSVSFLNVT
430 440
KSSLIWSYPA GSLTFPVRPF FYTGHR