A6H789

PR
Gene name
LRRC3B
Protein name
Leucine-rich repeat-containing protein 3B
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:783571
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

8-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6H789

Entry ID Method Resolution Chain Position Source
AF-A6H789-F1 Predicted AlphaFoldDB

29 variants for A6H789

Variant ID(s) Position Change Description Diseaes Association Provenance
rs452084758 29 H>Y No EVA
rs431997474 30 S>P No EVA
rs466561960 30 S>Y No EVA
rs453258289 51 S>I No EVA
rs467611815 86 D>G No EVA
rs450562904 88 H>P No EVA
rs483174179 93 L>H No EVA
rs469408762 94 N>T No EVA
rs446101870 96 S>T No EVA
rs460354871 217 V>G No EVA
rs440688358 218 I>V No EVA
rs444546582 223 Y>D No EVA
rs452269688 224 Y>* No EVA
rs476049885 224 Y>N No EVA
rs473017617 225 V>E No EVA
rs438497926 225 V>L No EVA
rs452896721 226 R>G No EVA
rs436305726 227 Q>H No EVA
rs467601968 228 N>K No EVA
rs457128523 229 Q>K No EVA
rs465159218 231 D>E No EVA
rs477280271 234 R>G No EVA
rs466820029 235 H>P No EVA
rs446761363 237 E>V No EVA
rs481773275 238 Y>N No EVA
rs461660761 239 L>F No EVA
rs451174849 241 S>A No EVA
rs438538354 243 P>Q No EVA
rs463458250 251 E>D No EVA

No associated diseases with A6H789

2 regional properties for A6H789

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 1 - 147 IPR000608
active_site Ubiquitin-conjugating enzyme, active site 74 - 89 IPR023313

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
extracellular matrix A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IWK6 ADGRA3 Adhesion G protein-coupled receptor A3 Homo sapiens (Human) PR
Q96PB8 LRRC3B Leucine-rich repeat-containing protein 3B Homo sapiens (Human) PR
Q7TT36 Adgra3 Adhesion G protein-coupled receptor A3 Mus musculus (Mouse) PR
Q8VCH9 Lrrc3b Leucine-rich repeat-containing protein 3B Mus musculus (Mouse) PR
10 20 30 40 50 60
MNLVDLWLTR SLSMCLLLQS FVLMILCFHS ASMCPKGCLC SSSGGLNVTC SNANLKEIPR
70 80 90 100 110 120
DLPPETVLLY LDSNQITSIP NEIFKDLHQL RVLNLSKNGI EFIDEHAFKG VAETLQTLDL
130 140 150 160 170 180
SDNRIQSVHK NAFNNLKARA RIANNPWHCD CTLQQVLRSM VSNHETAHNV ICKTSVLDEH
190 200 210 220 230 240
AGRPFLNAAN DADLCNLPKK TTDYAMLVTM FGWFTMVISY VVYYVRQNQE DARRHLEYLK
250
SLPSRQKKAD EPDDISTVV