A6H690
Gene name |
Iqca1l (Iqca1p1) |
Protein name |
IQ and AAA domain-containing protein 1-like |
Names |
Protein IQCA1P1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:231045 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6H690
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6H690-F1 | Predicted | AlphaFoldDB |
34 variants for A6H690
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs260391599 | 25 | P>S | No | EVA | |
| rs237747175 | 130 | S>G | No | EVA | |
| rs265230610 | 144 | N>S | No | EVA | |
| rs243850919 | 211 | I>V | No | EVA | |
| rs29561407 | 227 | E>K | No | EVA | |
| rs32005610 | 249 | L>M | No | EVA | |
| rs247110357 | 379 | V>A | No | EVA | |
| rs3388749660 | 384 | E>* | No | EVA | |
| rs3388749635 | 385 | V>L | No | EVA | |
| rs32006549 | 388 | R>K | No | EVA | |
| rs3388748091 | 404 | E>K | No | EVA | |
| rs261364547 | 408 | V>M | No | EVA | |
| rs3413113849 | 413 | Y>* | No | EVA | |
| rs242060510 | 434 | Q>E | No | EVA | |
| rs3388745231 | 449 | Q>* | No | EVA | |
| rs3388733341 | 460 | R>M | No | EVA | |
| rs3388749994 | 495 | L>Q | No | EVA | |
| rs3412959395 | 522 | Y>F | No | EVA | |
| rs3394725549 | 583 | Q>* | No | EVA | |
| rs3388733389 | 584 | A>V | No | EVA | |
| rs3388736875 | 613 | L>P | No | EVA | |
| rs33056918 | 649 | T>K | No | EVA | |
| rs3388742372 | 654 | R>G | No | EVA | |
| rs3388740424 | 664 | K>* | No | EVA | |
| rs3388733381 | 664 | K>N | No | EVA | |
| rs3388740424 | 664 | K>Q | No | EVA | |
| rs240192454 | 717 | S>N | No | EVA | |
| rs223271040 | 720 | R>M | No | EVA | |
| rs3388747759 | 739 | G>D | No | EVA | |
| rs3388722120 | 754 | T>R | No | EVA | |
| rs32010074 | 773 | G>V | No | EVA | |
| rs48902370 | 806 | T>S | No | EVA | |
| rs32010083 | 815 | A>V | No | EVA | |
| rs29776345 | 818 | T>A | No | EVA |
No associated diseases with A6H690
1 regional properties for A6H690
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 58 - 369 | IPR000719 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VQN8 | CG3326 | Fidgetin-like protein 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q6PIW4 | FIGNL1 | Fidgetin-like protein 1 | Homo sapiens (Human) | PR |
| Q9UBP0 | SPAST | Spastin | Homo sapiens (Human) | PR |
| Q86XH1 | IQCA1 | Dynein regulatory complex protein 11 | Homo sapiens (Human) | PR |
| A6NCM1 | IQCA1L | IQ and AAA domain-containing protein 1-like | Homo sapiens (Human) | PR |
| Q9CUL5 | Iqca1 | Dynein regulatory complex protein 11 | Mus musculus (Mouse) | PR |
| Q6AXQ7 | Iqca1l | IQ and AAA domain-containing protein 1-like | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEGTYQRLW | EASHVTLEEV | LEKEPSVLEP | VPSRERQSFQ | YRISVLYLYY | LGLLRRFNLA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YDQMVQPQKR | RLLRRLLDGV | AGRVLELKDE | LVRVDLCETH | CLDRVLQDLK | LTPADLEVPI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PKYFQLEQSS | AVKARQQMLA | DILNRLEPLV | SQENLRGLSR | TAALILVQSA | ERARQGRLRA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TFMREIRKEE | ERDRRIWENG | QQKFSRDQGA | IVIQKVWKGY | LQRKRIEQDR | RVEMEFIGML |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSPNQTARLN | TLNQAFLGEE | SRRMRQVEKE | EEFQEAIGKT | YESLTETEGP | DMKERMKDQI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RQWFIECHAL | TGRFPDYPDE | ASGGSYLIFA | DKTPEQVRLD | LEAQAQESRK | KDQEKKEKNK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EKEKEKKEKK | KKKVKEEKVK | KEPEVMFRVL | PSKSIPVINA | GHEEYTSVWK | SRYDNKHPSQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NFDSETLREE | KRKQVEMEIR | VQVDELMRQE | LKNLRLAVDR | EETRPLKSPK | KKGGKKSGKK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KKEKDLTPDR | SVDSLFEELV | IIGLIKKSAL | VTLSDYIGDC | LYLGSTLTLA | NKMPMPSLFD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IRQNMALYGV | LRLGSHDIHT | MAPLVRSILL | VGPSGMGKKM | LVQAVCTETG | ANLFDLSPDN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LMGKYPGKNG | AQLLVHIVFK | VARLLQPSVI | WIGNTEKTFY | KKVPKEERTM | DPKRIKKDLM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RATKQLSPGD | RVMLIGTTER | PQLAEMKGLC | RFYERILFIP | RPDYASRYVL | WKRMIESQGR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GVQLTSSLDV | SALARVSDGY | TPSHILQSIQ | SVLTERRLLQ | LIKKPLVASE | FVGHLARLDP |
| 790 | 800 | 810 | 820 | ||
| VYREEEESLK | EWFFKTPLGK | KNMKFTKDQL | EAEEARLTKE | KKKKK |