A5PK26
Gene name |
ACAP1 (CENTB1) |
Protein name |
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 |
Names |
Centaurin-beta-1 , Cnt-b1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:508582 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
403-525 (GAP domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A5PK26
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A5PK26-F1 | Predicted | AlphaFoldDB |
No variants for A5PK26
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A5PK26 | |||||
No associated diseases with A5PK26
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| recycling endosome membrane | The lipid bilayer surrounding a recycling endosome. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O97902 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
| A1Z7A6 | Asap | ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein | Drosophila melanogaster (Fruit fly) | SS |
| O43150 | ASAP2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | SS |
| Q15057 | ACAP2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | PR |
| Q8TDY4 | ASAP3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Homo sapiens (Human) | SS |
| Q9ULH1 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
| Q15027 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
| Q5U464 | Asap3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Mus musculus (Mouse) | SS |
| Q6ZQK5 | Acap2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Mus musculus (Mouse) | PR |
| Q7SIG6 | Asap2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Mus musculus (Mouse) | SS |
| Q9QWY8 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q8K2H4 | Acap1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q1AAU6 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Rattus norvegicus (Rat) | SS |
| Q9SMX5 | AGD4 | ADP-ribosylation factor GTPase-activating protein AGD4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C6C3 | AGD2 | ADP-ribosylation factor GTPase-activating protein AGD2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTVKLDFEEC | LKDSPRFRAS | VELVEAEVSE | LETRLEKLLK | LGNGLLESGR | HYLAASRAFI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGICDLAHLG | PPEPMMAECL | DKFTQSLSHK | LDSHAELLDA | TQHTLQRQIQ | TLVKEGLRSF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| REAGRDFWRG | AESLEAALTH | NAEVPRRRAQ | EAEEAGAALK | VARAGYRGRA | LDYALQINVI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EDKRKFDIME | FVLRLVEAQA | THFQQGHEEL | SQLAQYRKEL | GGQLHQLVLN | SAREKRDMEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RHVLLKQKEL | GGEEPEPSLK | EGPGGLVMEG | HLFKRASNAF | KTWSRRWFTI | QSNQLVYQKR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YKDPVTVVVD | DLRLCTVKLC | PDSERRFCFE | VVSPSKSCLL | QSDSERLMQL | WVSAVQSSIA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TAFSQARLDD | SPRGLGQGSG | HLAISSAATL | GPGGLTRGRE | PGGVGHVAAQ | VQSVDGNAQC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CDCREPAPEW | ASINLGVTLC | IQCSGIHRSL | GVHFSKVRSL | TLDSWEPELV | KLMCELGNVV |
| 490 | 500 | 510 | 520 | 530 | 540 |
| INQIYEARVE | AMAVKKPGPS | CSRQEKEAWI | HAKYVEKKFL | TKLPEIRGRR | GGRGPPRGHP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PVPPKPGLIR | PKPGSFRSKP | EPPSEDLQSL | HPGALLFRAA | GHPPSLPTMA | DALAHGADVN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| WVNGGQENAT | PLIQATAAVR | VLNSLLACEF | LLQNGANVNQ | VDNQGRGPLH | HATILGHTGL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ACLFLKRGAD | LGVRDSEGRD | PLTIAVETAN | ADIVTLLRLA | KMREADAAQG | QAGDETYLDI |
| 730 | 740 | ||||
| FRDFSLMASD | DPEKLSRRSH | DLHTL |