A5H2Z9

SS
Gene name
Tlr7
Protein name
Toll-like receptor 7
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:317468
EC number
Protein Class

Descriptions

TLR7 (Toll-like receptor 7) is an endosomal receptor that plays a key role in innate and adaptive immunity by recognizing pathogen-associated molecular patterns. TLR7 triggers antiviral immune responses by recognizing viral single-stranded RNA in endosomes. TLR7 is a type I transmembrane protein characterized by an extracellular leucine-rich repeat (LRR) domain, a transmembrane helix, and an intracellular Toll/interleukin-1 receptor (TIR) homology domain. Upon binding to agonists, TLR7 undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. TLR7 is also proteolytically cleaved in different human immune and nonimmune cells and that cleavage processing is required for functional activity. TLR7 cleavage generates within the loop between LRRs 14 and 15 and requires calcium-dependent serine proteases of the furin-like PC family.

Autoinhibitory domains (AIDs)

455-493 (Z-loop) SS

Target domain

27-846 (LRR domains)

Relief mechanism

Cleavage

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for A5H2Z9

Entry ID Method Resolution Chain Position Source

No variants for A5H2Z9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A5H2Z9

No associated diseases with A5H2Z9

No regional properties for A5H2Z9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A5H2Z9

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasmic vesicle, phagosome
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
  • Lysosome
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
early phagosome A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
endosome A vacuole to which materials ingested by endocytosis are delivered.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

4 GO annotations of molecular function

Name Definition
double-stranded RNA binding Binding to double-stranded RNA.
pattern recognition receptor activity Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response.
single-stranded RNA binding Binding to single-stranded RNA.
siRNA binding Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.

22 GO annotations of biological process

Name Definition
cellular response to mechanical stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
cellular response to virus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
I-kappaB kinase/NF-kappaB signaling The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
I-kappaB phosphorylation The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
JNK cascade An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers
positive regulation of chemokine production Any process that activates or increases the frequency, rate, or extent of chemokine production.
positive regulation of interferon-alpha production Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
positive regulation of interferon-beta production Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
positive regulation of interleukin-6 production Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
positive regulation of interleukin-8 production Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
positive regulation of macrophage cytokine production Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
positive regulation of NIK/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
positive regulation of type II interferon production Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
regulation of protein phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
response to cGMP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus.
toll-like receptor 7 signaling pathway The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 7.
toll-like receptor signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5I2M7 TLR9 Toll-like receptor 9 Felis catus (Cat) (Felis silvestris catus) SS
Q5I2M8 TLR9 Toll-like receptor 9 Canis lupus familiaris (Dog) (Canis familiaris) SS
P08953 Tl Protein toll Drosophila melanogaster (Fruit fly) PR
Q2EEY0 TLR9 Toll-like receptor 9 Equus caballus (Horse) SS
Q9NR96 TLR9 Toll-like receptor 9 Homo sapiens (Human) EV
Q9NYK1 TLR7 Toll-like receptor 7 Homo sapiens (Human) EV
P58681 Tlr7 Toll-like receptor 7 Mus musculus (Mouse) SS
Q9EQU3 Tlr9 Toll-like receptor 9 Mus musculus (Mouse) SS
Q5I2M3 TLR9 Toll-like receptor 9 Sus scrofa (Pig) SS
10 20 30 40 50 60
MVFPMWTLKR QSFIFLNMIL VSRVLGFRWY PKTLPCDVSL DSTNTHVIVD CTDKHLTEIP
70 80 90 100 110 120
EGIPTNTTNL TLTINHIPSI SPDSFHRLKH LEELDLRCNC VPILLGSKAN VCTKRLQIRP
130 140 150 160 170 180
GSFSGLSDLK SLYLDGNQLL EIPQDLPSSL QLLSLEANNI FSITKENLSE LVNIESLYLG
190 200 210 220 230 240
QNCYYRNPCN VSYSIEKDAF LVMKNLKVLS LKDNNVTAVP TILPPNLLEL YLYNNIIKRI
250 260 270 280 290 300
QEHDFNKLSQ LQVLDLSGNC PRCYNVPYPC TPCENNSPLQ IHDNAFDSLT ELKVLRLHSN
310 320 330 340 350 360
SLQHVPAEWF KNMSNLQELD LSQNYLAREI EEAKFLNSLP NLVQLDLSFN YELQVYHASI
370 380 390 400 410 420
TLPHSLSSLT KLKNLYIKGY VFKELKDSSL SVLHNLSNLE VLDLGTNFIK IADLNIFQQF
430 440 450 460 470 480
ENLKFIDLSV NKISPSEESR EVGLCPNAQT SVDWHGPQVL EALHYFRYDE YARSCRFKNK
490 500 510 520 530 540
EPPTFLPLNA DCHTYGKTLD LSRNNIFFIK PSDFKHLSFL KCLNLSGNAI GQTLNGSELQ
550 560 570 580 590 600
PLRELRYLDF SNNRLDLLYS TAFEELQNLE ILDLSSNSHY FQAEGITHML NFTKKLRHLE
610 620 630 640 650 660
KLMMNDNDIS TSASRTMESE SLRVLEFRGN HLDVLWRDGD NRYLDFFKNL LNLEELDISR
670 680 690 700 710 720
NSLNSVPPGV FEGMPPNLTT LSLAKNGLRS FSWGRLQLLK HLKNLDLSHN QLTTVPARLA
730 740 750 760 770 780
NCSKSLTKLI LNHNQIRQLT KYFLEDALQL RYLDISSNKI QVIQKTSFPE NVLNNLNMLL
790 800 810 820 830 840
LHHNRFLCNC DAVWFVWWVN HTDVTIPYLA TDVTCAGPGA HKGQSVISLD LYTCELDLTN
850 860 870 880 890 900
LILFSVSISS VLFLMIVMTT SHLFFWDMWY IYYFWKAKIK GYQHLQSMES CYDAFIVYDT
910 920 930 940 950 960
KNSAVTEWVL QELVVKLEDP REKHFNLCLE ERDWLPGQPV LENLSQSIQL SRKTVFVMTQ
970 980 990 1000 1010 1020
KYAKTESFKM AFYLSHQRLM DEKVDVIILI FLEKPLQKSK FLQLRKRLCS SSVLEWPTNP
1030 1040
QAHPYFWQCL KNALTTDNHV AYSQMFKETV