A4UTP7

SS
Gene name
MEF2C
Protein name
Myocyte-specific enhancer factor 2C
Names
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:733590
EC number
Protein Class

Descriptions

MEF2 factors regulate transcription during cardiac and skeletal myogenesis. Phosphorylation by p38 at Thr 293 and Thr 300 within a linker region, and Ser 387 within transcription repressor domain enhances MEF2C activity allosterically, which implicates potential mechanism of autoinhibition.

Autoinhibitory domains (AIDs)

269-357 (Linker) SS

Target domain

1-61 (Transcription factor, MADS-box)

Relief mechanism

PTM

Assay

358-389 (Transcription repressor domain) SS

Target domain

1-61 (Transcription factor, MADS-box)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4UTP7

Entry ID Method Resolution Chain Position Source
AF-A4UTP7-F1 Predicted AlphaFoldDB

No variants for A4UTP7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4UTP7

No associated diseases with A4UTP7

3 regional properties for A4UTP7

Type Name Position InterPro Accession
domain Transcription factor, MADS-box 1 - 61 IPR002100
domain Holliday junction regulator protein family C-terminal 95 - 152 IPR022102
domain MADS MEF2-like 2 - 78 IPR033896

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, sarcoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
sarcoplasm The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.

9 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
histone deacetylase binding Binding to histone deacetylase.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

63 GO annotations of biological process

Name Definition
B cell homeostasis The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
B cell proliferation The expansion of a B cell population by cell division. Follows B cell activation.
B cell receptor signaling pathway The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
blood vessel development The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
blood vessel remodeling The reorganization or renovation of existing blood vessels.
cardiac ventricle formation The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.
cardiocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.
cellular response to calcium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
cellular response to fluid shear stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to parathyroid hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus.
cellular response to transforming growth factor beta stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
cellular response to trichostatin A Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus.
cellular response to xenobiotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
chondrocyte differentiation The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
endochondral ossification Replacement ossification wherein bone tissue replaces cartilage.
epithelial cell proliferation involved in renal tubule morphogenesis Any epithelial cell proliferation that is involved in renal tubule morphogenesis.
germinal center formation The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.
glomerulus morphogenesis The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
heart looping The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
humoral immune response An immune response mediated through a body fluid.
learning or memory The acquisition and processing of information and/or the storage and retrieval of this information over time.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers
melanocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.
muscle cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of neuron apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
negative regulation of ossification Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
nephron tubule epithelial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state.
neural crest cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
neuron development The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron.
osteoblast differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
outflow tract morphogenesis The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.
platelet formation The process in which platelets bud from long processes extended by megakaryocytes.
positive regulation of alkaline phosphatase activity Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction
positive regulation of B cell proliferation Any process that activates or increases the rate or extent of B cell proliferation.
positive regulation of behavioral fear response Any process that activates or increases the frequency, rate or extent of behavioral fear response.
positive regulation of bone mineralization Any process that activates or increases the frequency, rate or extent of bone mineralization.
positive regulation of cardiac muscle cell differentiation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.
positive regulation of cardiac muscle cell proliferation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of macrophage apoptotic process Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process.
positive regulation of myoblast differentiation Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
positive regulation of neuron differentiation Any process that activates or increases the frequency, rate or extent of neuron differentiation.
positive regulation of osteoblast differentiation Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
positive regulation of skeletal muscle cell differentiation Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation.
positive regulation of skeletal muscle tissue development Any process that activates, maintains or increases the rate of skeletal muscle tissue development.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
primary heart field specification The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
regulation of germinal center formation Any process that modulates the frequency, rate, or extent of germinal center formation.
regulation of megakaryocyte differentiation Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.
regulation of synaptic activity Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
renal tubule morphogenesis The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.
secondary heart field specification The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).
sinoatrial valve morphogenesis The process in which the structure of the sinoatrial valve is generated and organized.
skeletal muscle tissue development The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are
smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.
ventricular cardiac muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A2VDZ3 MEF2A Myocyte-specific enhancer factor 2A Bos taurus (Bovine) SS
Q9W6U8 MEF2A Myocyte-specific enhancer factor 2A Gallus gallus (Chicken) SS
Q02078 MEF2A Myocyte-specific enhancer factor 2A Homo sapiens (Human) SS
Q06413 MEF2C Myocyte-specific enhancer factor 2C Homo sapiens (Human) EV
Q60929 Mef2a Myocyte-specific enhancer factor 2A Mus musculus (Mouse) SS
Q8CFN5 Mef2c Myocyte-specific enhancer factor 2C Mus musculus (Mouse) SS
A2ICN5 MEF2A Myocyte-specific enhancer factor 2A Sus scrofa (Pig) SS
Q2MJT0 Mef2a Myocyte-specific enhancer factor 2A Rattus norvegicus (Rat) SS
A0A096MJY4 Mef2c Myocyte-specific enhancer factor 2C Rattus norvegicus (Rat) SS
Q655V4 MADS30 MADS-box transcription factor 30 Oryza sativa subsp japonica (Rice) PR
Q40702 MADS2 MADS-box transcription factor 2 Oryza sativa subsp japonica (Rice) PR
Q5K4R0 MADS47 MADS-box transcription factor 47 Oryza sativa subsp japonica (Rice) PR
Q1PFA4 AGL30 Agamous-like MADS-box protein AGL30 Arabidopsis thaliana (Mouse-ear cress) PR
P29383 AGL3 Agamous-like MADS-box protein AGL3 Arabidopsis thaliana (Mouse-ear cress) PR
P35632 AP3 Floral homeotic protein APETALA 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q683D7 MAF5 Protein MADS AFFECTING FLOWERING 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FUY6 J MADS-box protein JOINTLESS Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS TNKLFQYAST
70 80 90 100 110 120
DMDKVLLKYT EYNEPHESRT NSDIVEALNK KENKGCESPD PDSSYALTPR TEEKYKKINE
130 140 150 160 170 180
EFDNMIKSHK IPAVPPPNFE MPVSIPVSSH NSLVYSNPVS SLGNPNFLPL AHPSLQRNSM
190 200 210 220 230 240
SPGVTHRPPS AGNTGGLMGG DLTSGAGTSA GNGYGNPRNS PGLLVSPGNL NKNMQAKSPP
250 260 270 280 290 300
PMNLGMNNRK PDLRVLIPPG SKNTMPSVSQ RINNSQSAQS LATPVVSVAT PTLPGQGMGG
310 320 330 340 350 360
YPSAISTTYG TEYSLSSADL SSLSGFNTAS ALHLGSVTGW QQQHLHNMPP SALSQLGACT
370 380 390 400 410 420
STHLSQSSNL SLPSTQSLNI KSEPVSPPRD RTTTPSRYPQ HTRHEAGRSP VDSLSSCSSS
430 440 450 460
YDGSDREDHR NEFHSPIGLT RPSPDERESP SVKRMRLSEG WAT