A4IIW7

PR
Gene name
cdk14 (pftk1)
Protein name
Cyclin-dependent kinase 14
Names
Cell division protein kinase 14
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:100125075
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-114 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

227-250 (Activation loop from InterPro)

Target domain

89-373 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for A4IIW7

Entry ID Method Resolution Chain Position Source
AF-A4IIW7-F1 Predicted AlphaFoldDB

No variants for A4IIW7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4IIW7

No associated diseases with A4IIW7

3 regional properties for A4IIW7

Type Name Position InterPro Accession
domain Protein kinase domain 89 - 373 IPR000719
active_site Serine/threonine-protein kinase, active site 206 - 218 IPR008271
binding_site Protein kinase, ATP binding site 95 - 118 IPR017441

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Recruited to the cell membrane by CCNY
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin binding Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

6 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
G2/M transition of mitotic cell cycle The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of canonical Wnt signaling pathway Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
regulation of transcription involved in G1/S transition of mitotic cell cycle Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00526 CDK3 Cyclin-dependent kinase 3 Homo sapiens (Human) PR
Q00537 CDK17 Cyclin-dependent kinase 17 Homo sapiens (Human) PR
Q96Q40 CDK15 Cyclin-dependent kinase 15 Homo sapiens (Human) PR
O94921 CDK14 Cyclin-dependent kinase 14 Homo sapiens (Human) PR
Q8K0D0 Cdk17 Cyclin-dependent kinase 17 Mus musculus (Mouse) PR
O35495 Cdk14 Cyclin-dependent kinase 14 Mus musculus (Mouse) PR
O35831 Cdk17 Cyclin-dependent kinase 17 Rattus norvegicus (Rat) PR
Q5Z754 CDKF-1 Cyclin-dependent kinase F-1 Oryza sativa subsp japonica (Rice) PR
Q9S713 STN7 Serine/threonine-protein kinase STN7, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q6P3N6 cdk8 Cyclin-dependent kinase 8 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q6GLD8 cdk9 Cyclin-dependent kinase 9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q1RLU9 cdk15 Cyclin-dependent kinase 15 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSTRNCQGID SVIKPLDTIP EDKKVRVQRT QSSFDPFEKT SNQVKRVHSE NNACINFKSA
70 80 90 100 110 120
SVGKESPKVR RHSSPSSPTS PKFGKADSYE KLEKLGEGSY ATVYKGKSKV NGKLVALKVI
130 140 150 160 170 180
RLQEEEGTPF TAIREASLLK GLKHANIVLL HDIIHTKETL TLVFEYVHTD LCQYMDKHPG
190 200 210 220 230 240
GLNPENVKLF LFQLLRGLSY IHQGHILHRD LKPQNLLISD TGELKLADFG LARAKSVPSH
250 260 270 280 290 300
TYSNEVVTLW YRPPDVLLGS TDYSTCLDMW GVGCIFVEMI QGVAAFPGMK DIQDQLERIF
310 320 330 340 350 360
LILGTPNEET WPGVHSLPHF KLERFTQYGP KNLRQAWNKL SYVNHAEDLA SKLLQCFPKN
370 380 390 400 410 420
RLSAQAALNH DYFSDLPPRL WELSDMSSIF TVPNVKLQPE AGESMRVFGK NNSFSKSLSN
SKH