Descriptions

Myosin light chain kinases (MLCK) are members of the family of Ca2+-calmodulin-dependent protein kinases. This enzyme contains an autoinhibitory pseudosubstrate sequence that blocks the substrate-binding site of the kinase. The autoinhibitory sequence makes an extensive network of contacts on the surface of the larger C-domain of the catalytic core extending towards the catalytic cleft with the CaM-binding sequence to block the regulatory light chain of sarcomeric myosin, but not ATP binding in the catalytic core N-domain.

Autoinhibitory domains (AIDs)

Target domain

312-567 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for A4IFM7

Entry ID Method Resolution Chain Position Source
AF-A4IFM7-F1 Predicted AlphaFoldDB

254 variants for A4IFM7

Variant ID(s) Position Change Description Diseaes Association Provenance
rs450507487 2 A>E No EVA
rs468857589 3 T>P No EVA
rs451186971 8 V>A No EVA
rs451186971 8 V>E No EVA
rs435055770 17 T>A No EVA
rs455727362 19 T>P No EVA
rs437916331 23 A>D No EVA
rs471506876 29 P>A No EVA
rs442536528 34 K>Q No EVA
rs460971533 35 D>A No EVA
rs482614509 36 P>T No EVA
rs443238624 38 P>A No EVA
rs443238624 38 P>S No EVA
rs467211152 42 Q>H No EVA
rs445417212 42 Q>K No EVA
rs479215407 43 K>* No EVA
rs456367656 44 D>E No EVA
rs438004581 44 D>G No EVA
rs467658326 44 D>Y No EVA
rs465133804 46 G>R No EVA
rs432236409 46 G>V No EVA
rs453915717 47 P>A No EVA
rs453915717 47 P>T No EVA
rs442542274 48 P>L No EVA
rs472448198 48 P>S No EVA
rs476292749 49 D>N No EVA
rs476292749 49 D>Y No EVA
rs458505326 52 K>N No EVA
rs476969248 56 P>T No EVA
rs439102575 57 P>A No EVA
rs460757037 57 P>Q No EVA
rs479261700 61 K>Q No EVA
rs449394137 62 E>D No EVA
rs467748091 63 L>P No EVA
rs432342086 67 D>A No EVA
rs465221679 67 D>Y No EVA
rs447560342 69 K>T No EVA
rs466020108 70 K>T No EVA
rs454706439 71 E>D No EVA
rs436229888 71 E>K No EVA
rs470614738 73 D>E No EVA
rs452192044 73 D>G No EVA
rs436911301 73 D>Y No EVA
rs717753623 74 P>L No EVA
rs440746526 75 D>G No EVA
rs460898188 76 S>P No EVA
rs472867337 77 T>S No EVA
rs438282222 83 P>L No EVA
rs443047930 83 P>S No EVA
rs483000367 84 A>T No EVA
rs450113310 89 D>Y No EVA
rs458841052 90 G>R No EVA
rs458841052 90 G>W No EVA
rs466117503 95 P>H No EVA
rs447577242 95 P>T No EVA
rs724123856 96 S>L No EVA
rs436262246 103 E>G No EVA
rs452230271 108 L>R No EVA
rs470668402 109 Q>K No EVA
rs434416520 111 E>A No EVA
rs452815831 113 A>P No EVA
rs472965999 114 E>G No EVA
rs461448729 120 P>T No EVA
rs459096446 121 A>E No EVA
rs459096446 121 A>G No EVA
rs443749291 121 A>P No EVA
rs477534868 122 A>D No EVA
rs447687245 123 L>P No EVA
rs447687245 123 L>R No EVA
rs481436450 125 Q>P No EVA
rs448393447 127 T>A No EVA
rs470036944 127 T>K No EVA
rs482057666 130 A>G No EVA
rs445859664 131 E>* No EVA
rs445859664 131 E>Q No EVA
rs464290442 132 A>G No EVA
rs434463707 133 S>G No EVA
rs434463707 133 S>R No EVA
rs452943167 134 V>G No EVA
rs380448652 134 V>I No EVA
rs435105478 135 K>N No EVA
rs468166440 135 K>Q No EVA
rs714117717 138 E>K No EVA
rs443827368 144 P>L No EVA
rs443827368 144 P>R No EVA
rs452608460 145 G>R No EVA
rs717172003 145 G>V No EVA
rs383733922 146 S>I No EVA
rs383733922 146 S>N No EVA
rs459802791 148 D>E No EVA
rs441315038 148 D>Y No EVA
rs442032391 154 E>D No EVA
rs463699074 155 Q>H No EVA
rs482094586 157 K>N No EVA
rs445896576 158 V>E No EVA
rs479629355 160 E>G No EVA
rs446507092 161 G>A No EVA
rs435193365 163 A>E No EVA
rs435193365 163 A>G No EVA
rs456754549 165 S>R No EVA
rs470346812 167 K>R No EVA
rs437474747 168 G>A No EVA
rs471177287 169 S>* No EVA
rs452749853 169 S>P No EVA
rs453377215 170 P>H No EVA
rs442070858 171 A>P No EVA
rs457994667 174 H>L No EVA
rs439508464 174 H>Y No EVA
rs446622785 175 S>N No EVA
rs446622785 175 S>T No EVA
rs461710306 177 S>R No EVA
rs456340767 185 L>I No EVA
rs456340767 185 L>V No EVA
rs438541819 189 L>Q No EVA
rs453830382 190 A>P No EVA
rs472270154 192 K>E No EVA
rs442469537 192 K>R No EVA
rs460925726 193 P>A No EVA
rs444752232 194 L>Q No EVA
rs476178423 194 L>V No EVA
rs478495655 195 D>H No EVA
rs445388623 195 D>V No EVA
rs460684663 205 V>G No EVA
rs478897512 208 T>P No EVA
rs449263302 213 E>G No EVA
rs467625598 215 E>* No EVA
rs449976598 219 V>E No EVA
rs437910125 219 V>I No EVA
rs465212795 222 G>* No EVA
rs432199853 225 N>S No EVA
rs453819247 237 K>N No EVA
rs524846653 241 H>D No EVA
rs476215258 247 V>G No EVA
rs443236678 251 T>A No EVA
rs472053628 254 G>A No EVA
rs463313236 254 G>R No EVA
rs439022820 263 E>A No EVA
rs478985035 269 Q>K No EVA
rs449298387 271 L>I No EVA
rs461240023 275 A>G No EVA
rs482867044 279 D>A No EVA
rs449997790 279 D>E No EVA
rs432254304 283 I>S No EVA
rs463665380 325 A>E No EVA
rs442032090 325 A>S No EVA
rs439420675 326 V>F No EVA
rs479383714 337 K>N No EVA
rs461636600 351 K>N No EVA
rs447459190 352 E>* No EVA
rs465933062 352 E>A No EVA
rs436099665 352 E>D No EVA
rs454567247 385 F>I No EVA
rs469777998 386 M>V No EVA
rs456527630 398 I>N No EVA
rs481175832 412 V>G No EVA
rs448129953 413 F>V No EVA
rs469895771 414 V>F No EVA
rs436810114 425 H>P No EVA
rs445611707 433 D>G No EVA
rs463955772 434 L>P No EVA
rs438835409 437 E>* No EVA
rs460383207 439 I>L No EVA
rs479016314 439 I>N No EVA
rs479016314 439 I>S No EVA
rs449129858 440 L>P No EVA
rs467685659 442 V>F No EVA
rs482915858 443 N>K No EVA
rs465126071 444 T>N No EVA
rs449885844 444 T>P No EVA
rs447339264 445 T>P No EVA
rs465733875 445 T>R No EVA
rs455995468 447 H>Q No EVA
rs435978540 447 H>Y No EVA
rs474507754 448 L>W No EVA
rs438227107 449 V>A No EVA
rs471763354 456 L>M No EVA
rs438874044 456 L>P No EVA
rs461371485 460 Y>D No EVA
rs461371485 460 Y>N No EVA
rs476557036 462 P>R No EVA
rs458821069 467 K>Q No EVA
rs441382435 468 V>A No EVA
rs441382435 468 V>G No EVA
rs447469156 469 N>S No EVA
rs459446904 480 V>G No EVA
rs469811690 482 N>K No EVA
rs448041648 482 N>S No EVA
rs481616018 484 D>A No EVA
rs465478927 485 Q>R No EVA
rs466294584 492 M>I No EVA
rs436495349 493 W>* No EVA
rs454902292 494 S>R No EVA
rs476643750 495 L>M No EVA
rs443642951 495 L>Q No EVA
rs476643750 495 L>V No EVA
rs470898314 496 G>R No EVA
rs441065641 498 I>F No EVA
rs459552658 498 I>T No EVA
rs458333856 502 L>R No EVA
rs479983755 504 S>R No EVA
rs446890652 505 G>R No EVA
rs468557673 510 L>Q No EVA
rs450744538 511 G>R No EVA
rs469084754 511 G>V No EVA
rs451411828 518 L>Q No EVA
rs455415700 525 N>S No EVA
rs473850785 531 E>A No EVA
rs444024482 538 D>E No EVA
rs476121231 548 I>T No EVA
rs439907046 549 V>A No EVA
rs480009607 551 D>G No EVA
rs440532284 552 Q>K No EVA
rs462248516 552 Q>L No EVA
rs462248516 552 Q>P No EVA
rs471638448 554 A>D No EVA
rs438769544 556 M>L No EVA
rs460470532 556 M>R No EVA
rs478979649 557 S>R No EVA
rs449040260 558 A>S No EVA
rs461150816 559 A>P No EVA
rs482804207 559 A>V No EVA
rs449848936 561 C>Y No EVA
rs465038240 564 H>L No EVA
rs465038240 564 H>P No EVA
rs431995776 569 N>T No EVA
rs447251261 573 K>R No EVA
rs465697030 575 K>N No EVA
rs434277272 576 R>L No EVA
rs134424118 578 N>H No EVA
rs1115421488 579 R>C No EVA
rs455866417 582 K>N No EVA
rs474255555 583 S>F No EVA
rs438137510 587 L>H No EVA
rs438858320 590 Y>C No EVA
rs471932124 590 Y>H No EVA
rs438858320 590 Y>S No EVA
rs472542137 592 M>I No EVA
rs454108197 592 M>K No EVA
rs454108197 592 M>R No EVA
rs461240565 595 R>L No EVA
rs442749241 595 R>S No EVA
rs482841376 596 W>G No EVA
rs443428591 596 W>L No EVA
rs458694599 597 K>N No EVA
rs472994988 605 A>S No EVA
rs441532646 606 A>S No EVA
rs460032572 607 N>H No EVA
rs442257230 608 R>L No EVA
rs463923851 612 I>V No EVA
rs482380472 613 S>N No EVA
rs446084367 613 S>R No EVA
rs464562814 615 S>A No EVA
rs479850252 617 A>V No EVA
rs468295435 624 V>L No EVA

No associated diseases with A4IFM7

5 regional properties for A4IFM7

Type Name Position InterPro Accession
domain Protein kinase domain 249 - 500 IPR000719
active_site Serine/threonine-protein kinase, active site 364 - 376 IPR008271
binding_site Protein kinase, ATP binding site 255 - 278 IPR017441
domain p21 activated kinase binding domain 72 - 117 IPR033923
domain p21-activated kinase 2, catalytic domain 229 - 524 IPR035064

Functions

Description
EC Number 2.7.11.18 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
myosin light chain binding Binding to a light chain of a myosin complex.
myosin light chain kinase activity Catalysis of the reaction

7 GO annotations of biological process

Name Definition
cardiac muscle tissue morphogenesis The process in which the anatomical structures of cardiac muscle tissue are generated and organized.
neuromuscular synaptic transmission The process of synaptic transmission from a neuron to a muscle, across a synapse.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of muscle filament sliding Any process that modulates the frequency, rate or extent of muscle filament sliding.
skeletal muscle satellite cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a satellite cell.
striated muscle contraction A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.

102 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0VD22 STK33 Serine/threonine-protein kinase 33 Bos taurus (Bovine) PR
Q0V7M1 PSKH1 Serine/threonine-protein kinase H1 Bos taurus (Bovine) SS
Q2KJ16 PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Bos taurus (Bovine) PR
Q3MHJ9 CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta Bos taurus (Bovine) SS
Q2HJF7 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta Bos taurus (Bovine) SS
Q96NX5 CAMK1G Calcium/calmodulin-dependent protein kinase type 1G Homo sapiens (Human) SS
O15075 DCLK1 Serine/threonine-protein kinase DCLK1 Homo sapiens (Human) EV
Q14012 CAMK1 Calcium/calmodulin-dependent protein kinase type 1 Homo sapiens (Human) EV
Q9UIK4 DAPK2 Death-associated protein kinase 2 Homo sapiens (Human) EV
O94768 STK17B Serine/threonine-protein kinase 17B Homo sapiens (Human) PR
Q86YV6 MYLK4 Myosin light chain kinase family member 4 Homo sapiens (Human) SS
Q16566 CAMK4 Calcium/calmodulin-dependent protein kinase type IV Homo sapiens (Human) SS
P11801 PSKH1 Serine/threonine-protein kinase H1 Homo sapiens (Human) SS
Q8N568 DCLK2 Serine/threonine-protein kinase DCLK2 Homo sapiens (Human) PR
Q9UEE5 STK17A Serine/threonine-protein kinase 17A Homo sapiens (Human) SS
O75962 TRIO Triple functional domain protein Homo sapiens (Human) EV
Q32MK0 MYLK3 Myosin light chain kinase 3 Homo sapiens (Human) SS
Q8WWF8 CAPSL Calcyphosin-like protein Homo sapiens (Human) PR
P53355 DAPK1 Death-associated protein kinase 1 Homo sapiens (Human) EV
Q6P2M8 PNCK Calcium/calmodulin-dependent protein kinase type 1B Homo sapiens (Human) SS
Q9BYT3 STK33 Serine/threonine-protein kinase 33 Homo sapiens (Human) PR
Q8NCB2 CAMKV CaM kinase-like vesicle-associated protein Homo sapiens (Human) SS
O43293 DAPK3 Death-associated protein kinase 3 Homo sapiens (Human) PR
Q8IU85 CAMK1D Calcium/calmodulin-dependent protein kinase type 1D Homo sapiens (Human) SS
Q9H1R3 MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle Homo sapiens (Human) EV
Q9QYK9 Pnck Calcium/calmodulin-dependent protein kinase type 1B Mus musculus (Mouse) PR
Q91VB2 Camk1g Calcium/calmodulin-dependent protein kinase type 1G Mus musculus (Mouse) SS
Q8BG48 Stk17b Serine/threonine-protein kinase 17B Mus musculus (Mouse) PR
Q6PGN3 Dclk2 Serine/threonine-protein kinase DCLK2 Mus musculus (Mouse) PR
Q91YS8 Camk1 Calcium/calmodulin-dependent protein kinase type 1 Mus musculus (Mouse) SS
Q3UIZ8 Mylk3 Myosin light chain kinase 3 Mus musculus (Mouse) SS
Q8VDF3 Dapk2 Death-associated protein kinase 2 Mus musculus (Mouse) EV
Q6P8Y1 Capsl Calcyphosin-like protein Mus musculus (Mouse) PR
Q8BW96 Camk1d Calcium/calmodulin-dependent protein kinase type 1D Mus musculus (Mouse) SS
Q3UHL1 Camkv CaM kinase-like vesicle-associated protein Mus musculus (Mouse) SS
P08414 Camk4 Calcium/calmodulin-dependent protein kinase type IV Mus musculus (Mouse) SS
Q9JLM8 Dclk1 Serine/threonine-protein kinase DCLK1 Mus musculus (Mouse) SS
Q91YA2 Pskh1 Serine/threonine-protein kinase H1 Mus musculus (Mouse) SS
Q80YE7 Dapk1 Death-associated protein kinase 1 Mus musculus (Mouse) SS
Q62407 Speg Striated muscle-specific serine/threonine-protein kinase Mus musculus (Mouse) SS
Q0KL02 Trio Triple functional domain protein Mus musculus (Mouse) SS
Q924X7 Stk33 Serine/threonine-protein kinase 33 Mus musculus (Mouse) PR
O54784 Dapk3 Death-associated protein kinase 3 Mus musculus (Mouse) PR
Q8VCR8 Mylk2 Myosin light chain kinase 2, skeletal/cardiac muscle Mus musculus (Mouse) SS
Q7TNJ7 Camk1g Calcium/calmodulin-dependent protein kinase type 1G Rattus norvegicus (Rat) SS
F1M0Z1 Trio Triple functional domain protein Rattus norvegicus (Rat) SS
Q91XS8 Stk17b Serine/threonine-protein kinase 17B Rattus norvegicus (Rat) PR
O08875 Dclk1 Serine/threonine-protein kinase DCLK1 Rattus norvegicus (Rat) PR
E9PT87 Mylk3 Myosin light chain kinase 3 Rattus norvegicus (Rat) SS
O70150 Pnck Calcium/calmodulin-dependent protein kinase type 1B Rattus norvegicus (Rat) PR
Q63092 Camkv CaM kinase-like vesicle-associated protein Rattus norvegicus (Rat) SS
Q63638 Speg Striated muscle-specific serine/threonine-protein kinase Rattus norvegicus (Rat) SS
O88764 Dapk3 Death-associated protein kinase 3 Rattus norvegicus (Rat) PR
P13234 Camk4 Calcium/calmodulin-dependent protein kinase type IV Rattus norvegicus (Rat) SS
Q63450 Camk1 Calcium/calmodulin-dependent protein kinase type 1 Rattus norvegicus (Rat) EV
P97924 Kalrn Kalirin Rattus norvegicus (Rat) SS
Q5MPA9 Dclk2 Serine/threonine-protein kinase DCLK2 Rattus norvegicus (Rat) PR
P20689 Mylk2 Myosin light chain kinase 2, skeletal/cardiac muscle Rattus norvegicus (Rat) SS
Q5VQQ5 CPK2 Calcium-dependent protein kinase 2 Oryza sativa subsp. japonica (Rice) SS
Q8LPZ7 CPK3 Calcium-dependent protein kinase 3 Oryza sativa subsp. japonica (Rice) SS
Q6K968 CPK6 Calcium-dependent protein kinase 6 Oryza sativa subsp. japonica (Rice) SS
P53684 CPK7 Calcium-dependent protein kinase 7 Oryza sativa subsp japonica (Rice) PR
Q75GE8 CPK8 Calcium-dependent protein kinase 8 Oryza sativa subsp. japonica (Rice) SS
Q6I5I8 CPK16 Calcium-dependent protein kinase 16 Oryza sativa subsp. japonica (Rice) SS
Q6AVM3 CCAMK Calcium and calcium/calmodulin-dependent serine/threonine-protein kinase Oryza sativa subsp japonica (Rice) PR
Q84SL0 CPK20 Calcium-dependent protein kinase 20 Oryza sativa subsp. japonica (Rice) SS
P53682 CPK23 Calcium-dependent protein kinase 23 Oryza sativa subsp japonica (Rice) PR
Q9TXJ0 cmk-1 Calcium/calmodulin-dependent protein kinase type 1 Caenorhabditis elegans PR
O44997 dapk-1 Death-associated protein kinase dapk-1 Caenorhabditis elegans SS
Q95QC4 zyg-8 Serine/threonine-protein kinase zyg-8 Caenorhabditis elegans PR
P28583 Calcium-dependent protein kinase SK5 Glycine max (Soybean) (Glycine hispida) PR
Q9M9V8 CPK10 Calcium-dependent protein kinase 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q39016 CPK11 Calcium-dependent protein kinase 11 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FX86 CRK8 CDPK-related kinase 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SSF8 CPK30 Calcium-dependent protein kinase 30 Arabidopsis thaliana (Mouse-ear cress) PR
Q38872 CPK6 Calcium-dependent protein kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q7XJR9 CPK16 Calcium-dependent protein kinase 16 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIQ7 CPK24 Calcium-dependent protein kinase 24 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SJ61 CPK25 Calcium-dependent protein kinase 25 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZV15 CPK20 Calcium-dependent protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) PR
P93759 GK-1 Calcium-dependent protein kinase 14 Arabidopsis thaliana (Mouse-ear cress) PR
Q8S8S2 LPEAT2 Lysophospholipid acyltransferase LPEAT2 Arabidopsis thaliana (Mouse-ear cress) PR
Q38870 CPK2 Calcium-dependent protein kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LJL9 CRK2 CDPK-related kinase 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SG12 CRK6 CDPK-related kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SCS2 CRK5 CDPK-related kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W4I7 CPK13 Calcium-dependent protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) PR
Q6NLQ6 CPK32 Calcium-dependent protein kinase 32 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZSA4 CPK27 Calcium-dependent protein kinase 27 Arabidopsis thaliana (Mouse-ear cress) PR
Q38869 CPK4 Calcium-dependent protein kinase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q42479 CPK3 Calcium-dependent protein kinase 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q1PE17 CPK18 Calcium-dependent protein kinase 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q06850 CPK1 Calcium-dependent protein kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FMP5 CPK17 Calcium-dependent protein kinase 17 Arabidopsis thaliana (Mouse-ear cress) PR
Q38873 CPK7 Calcium-dependent protein kinase 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E9C0 CPK34 Calcium-dependent protein kinase 34 Arabidopsis thaliana (Mouse-ear cress) PR
Q42438 CPK8 Calcium-dependent protein kinase 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q42396 CPK12 Calcium-dependent protein kinase 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FKW4 CPK28 Calcium-dependent protein kinase 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q1LUA6 trio Triple functional domain protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
A8C984 mylk3 Myosin light chain kinase 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q7SY49 camkv CaM kinase-like vesicle-associated protein Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MATENGAVEL EIPSSSTDTA PKAAAGEGPP AAEKDPGPPD PQKDPGPPDP EKDAGPPNPE
70 80 90 100 110 120
KELESPDPKK EPDPDSTKDT EAPAPEKGDG ASAQPSASSQ GPEGEGGLQG EPAEGSAGQP
130 140 150 160 170 180
AALPQETATA EASVKKPEAE QGTPGSQDPG EAKEQKKVAE GQAPSKKGSP AFLHSPSCPA
190 200 210 220 230 240
AISSLEKPLA EKPLDETLEL IFEGVPVTPG PTETEPAKVA EGEKNLPGGS QKEGEEKAAG
250 260 270 280 290 300
HAGQDGVQGD TSRGIEFQAV PSERSEVGQA LSPTAKEEDC FQILDDCPPP PAPFPHRIVE
310 320 330 340 350 360
LRPGNINSQF SLNSKEALGG GKFGAVCTCT EKATGLKLAA KVIKKQTPKD KEMVLLEIEV
370 380 390 400 410 420
MNQLNHRNLI QLYAAIETPH EIVLFMEYIE GGELFERIVD EDYQLTEVDT MVFVRQICDG
430 440 450 460 470 480
ILFMHKMRVL HLDLKPENIL CVNTTGHLVK IIDFGLARRY NPNEKLKVNF GTPEFLSPEV
490 500 510 520 530 540
VNYDQISDKT DMWSLGVITY MLLSGLSPFL GDDDTETLNN VLSSNWYFDE ETFEAVSDEA
550 560 570 580 590 600
KDFVSNLIVK DQRARMSAAQ CLAHPWLNNL AEKAKRCNRR LKSQILLKKY LMKRRWKKNF
610 620
IAVSAANRFK KISSSGALMA LGV