A4FUD6

SS
Gene name
ELMO2
Protein name
Engulfment and cell motility protein 2
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:508361
EC number
Protein Class

Descriptions

Engulfment and cell motility (ELMO) proteins bind a subset of DOCK members and act as critical regulators of Rac signaling. Although formation of a DOCK180/ELMO complex is not essential for Rac1 activation, ELMO mutants deficient in binding to DOCK180 are unable to promote cytoskeleton remodeling. ELMO facilitates the co-localization of DOCK180 and Rac at the membrane and therefore indirectly endorses the Rac GEF activity of this complex. ELMO is autoinhibited via an intramolecular interaction between the N-terminal Armadillo repeats (ARMs, renamed ELMO Inhibitory Domain (EID)) and the C-terminal region termed the ELMO Autoregulatory Domain (EAD). Relief of ELMO autoinhibition occurs through cell stimulation and ELMO Ras-binding domain (RBD) engagement (via a GTPase or other unknown binding partner). Cell stimulation leads to ELMO conformational changes that facilitate DOCK180/ELMO interactions, which in turn enhances the Rac GEF activity in DOCK180.

Autoinhibitory domains (AIDs)

113-307 (Armadillo repeats, EID) SS

Target domain

1-113 (Ras-binding domain)

Relief mechanism

Partner binding

Assay

669-700 (ELMO autoregulatory domain, EAD) SS

Target domain

1-113 (Ras-binding domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4FUD6

Entry ID Method Resolution Chain Position Source
AF-A4FUD6-F1 Predicted AlphaFoldDB

No variants for A4FUD6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4FUD6

No associated diseases with A4FUD6

4 regional properties for A4FUD6

Type Name Position InterPro Accession
domain Homeobox domain 505 - 569 IPR001356
conserved_site Homeobox, conserved site 540 - 563 IPR017970
domain Homeobox domain, metazoa 529 - 540 IPR020479-1
domain Homeobox domain, metazoa 544 - 563 IPR020479-2

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytosol
  • Membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

1 GO annotations of molecular function

Name Definition
SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

5 GO annotations of biological process

Name Definition
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cell chemotaxis The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
cell motility Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q08DZ3 ELMOD2 ELMO domain-containing protein 2 Bos taurus (Bovine) PR
Q92556 ELMO1 Engulfment and cell motility protein 1 Homo sapiens (Human) EV
Q96BJ8 ELMO3 Engulfment and cell motility protein 3 Homo sapiens (Human) SS
Q96JJ3 ELMO2 Engulfment and cell motility protein 2 Homo sapiens (Human) SS
Q8BPU7 Elmo1 Engulfment and cell motility protein 1 Mus musculus (Mouse) SS
Q8BYZ7 Elmo3 Engulfment and cell motility protein 3 Mus musculus (Mouse) SS
Q8BHL5 Elmo2 Engulfment and cell motility protein 2 Mus musculus (Mouse) SS
Q499U2 Elmo3 Engulfment and cell motility protein 3 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MPPPSDIVKV AIEWPGANAQ LLEIDQKRPL ASIIKEVCDG WSLPNPEYYT LRYADGPQLY
70 80 90 100 110 120
ITEQTRSDIK NGTILQLAIS PSRAARQLME RTQSSSMETR LDAMKELAKL SADVTFATEF
130 140 150 160 170 180
INMDGIVVLT RLVESGTKLL SHYSEMLAFT LTAFLELMDH GIVSWDMVSI TFIKQIAGYV
190 200 210 220 230 240
SQPMVDVSIL QRSLAILESM VLNSQSLYQK IAEEITVGQL ISHLQVSNQE IQTYAIALIN
250 260 270 280 290 300
ALFLKAPEDK RQDMANAFAQ KHLRSIILNH VIRGNRPIKT EMAHQLYVLQ VLTFNLLEER
310 320 330 340 350 360
MMTKMDPNDQ AQRDIIFELR RIAFDADSDP SNAPGSGTEK RKAMYTKDYK MLGFTNHINP
370 380 390 400 410 420
AMDFTQTPPG MLALDNMLYL AKVHQDTYIR IVLENSSRED KHECPFGRSA IELTKMLCEI
430 440 450 460 470 480
LQVGELPNEG RNDYHPMFFT HDRAFEELFG ICIQLLNKTW KEMRATAEDF NKVMQVVREQ
490 500 510 520 530 540
ITRALPSKPN SLDQFKSKLR SLSYSEILRL RQSERMSQDD FQSPPIVELR EKIQPEILEL
550 560 570 580 590 600
IKQQRLNRLC EGSSFRKIGN RRRQERFWYC RLALNHKVLH YGDLDDNPQG EVTFESLQEK
610 620 630 640 650 660
IPVADIKAIV TGKDCPHMKE KSALKQNKEV LELAFSILYD PDETLNFIAP NKYEYCIWID
670 680 690 700 710
GLSALLGKDM SSELTKSDRD TLLSMEMKLR LLDLENIQIP EAPPPVPKEP SSYDFVYHYG