A3KMX0

PR
Gene name
ERCC6L2
Protein name
DNA excision repair protein ERCC-6-like 2
Names
Species
Bos taurus (Bovine)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

732-814 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3KMX0

Entry ID Method Resolution Chain Position Source
AF-A3KMX0-F1 Predicted AlphaFoldDB

No variants for A3KMX0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3KMX0

No associated diseases with A3KMX0

3 regional properties for A3KMX0

Type Name Position InterPro Accession
domain Protein kinase domain 70 - 367 IPR000719
active_site Serine/threonine-protein kinase, active site 188 - 200 IPR008271
binding_site Protein kinase, ATP binding site 76 - 99 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Mitochondrion
  • Colocalizes with NEK6 in the centrosome
  • In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (ROS)-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent chromatin remodeler activity An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

1 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2NKX8 ERCC6L DNA excision repair protein ERCC-6-like Homo sapiens (Human) PR
Q03468 ERCC6 DNA excision repair protein ERCC-6 Homo sapiens (Human) EV
F8VPZ5 Ercc6 DNA excision repair protein ERCC-6 Mus musculus (Mouse) SS
Q9ZV43 CHR8 Protein CHROMATIN REMODELING 8 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MQPGCQALPP GQMDQSTPKP HAETNSKDIW HPGERCLAPS PDNEKLCEAS IKSITVDENG
70 80 90 100 110 120
KSFAVILYSN FQERRVPLKR LQEVKSVKDC SRNFIFDDED LEKPYFPDRK FPSSAVPFQL
130 140 150 160 170 180
SENGDSIPYT INRYLRDYQR EGAQFLYGHF IQGRGCILGD DMGLGKTVQV ISFLAAVLGK
190 200 210 220 230 240
KGTREDIENN MPEFLLRNMK KDPPSTAKKM FLIVAPLSVL YNWKDELDTW GYFRVTILHG
250 260 270 280 290 300
NKKDSELIRV KQRKCEIALT TYETLRLCLD ELNSLEWSAV IVDEAHRIKN PKARVTEIMK
310 320 330 340 350 360
ALRCNVRIGL TGTILQNNMK ELWCVMDWAV PGLLGSRIHF KKQFSDPVEH GQRHTATKRE
370 380 390 400 410 420
LATGRKAMQR LARKMSGWFL RRTKTLIKDQ LPKKEDRMVY CSLTDFQKAV YQTVLETEDV
430 440 450 460 470 480
SLILQSSEPC TCNSGQKRRN CCYKTNSQGE TVKTLYFSYL AVLQKVANHV ALLQTASTSR
490 500 510 520 530 540
QQETLIKRIC DQVFSRFPDF VQKSKDAAFE TLSDPKYSGK MKVLQQLLNH CRKNKDKVLL
550 560 570 580 590 600
FSFSTKLLDV LQQYCMASGL DYRRLDGSTK SEERIKIVKE FNSTQDVNIC LVSTMAGGLG
610 620 630 640 650 660
LNFVGANVVV LFDPTWNPAN DLQAIDRAYR IGQCRDVKVL RLISLGTVEE IMYLRQVYKQ
670 680 690 700 710 720
QLHCVVVGSE NAKRYFEAVQ GSKEHQGELF GVYNLFKLRS QGSCLTRDIL EREGKVEAGI
730 740 750 760 770 780
MTATTWLKEE PPVHKLETAR EPDCREHRGP EQLAEAACDL CSDFSEDETA SNSVTKTVKN
790 800 810 820 830 840
KASDSSRASV SPGQFSLLQC GFSKLFETKC ETVEDGDENI ASDNESSDEQ PTCFSTEAKN
850 860 870 880 890 900
AGCQKSQDSL GTLKHQKLAN VLNPNGKCVF EKSEKILKEN IPSESDDEKN FKNTVDHHHI
910 920 930 940 950 960
LQNVTESEDS DIIFPTQYTT QRFLKKNIRF KPPVDGSEDS ESENPVNIKN NGDDTKTNVR
970 980 990 1000 1010 1020
GNGLISKQLN LEIETLKSNT KRKGGSDISD ESDDIEVFCK SRVRKQRATS SLRFKRKKEN
1030 1040 1050 1060 1070 1080
KRELYTFPKT MKKANQQCAT DEDCNSQTID DFSSSDDNLS VGHISFSKQN HRPKTIKDKI
1090 1100 1110 1120 1130 1140
SVSSKLTNHK RNSTFIPRKP MKFSNESVVN QNRICESMDK FLDGVQEVAY IHSNQNVIGS
1150 1160 1170 1180 1190 1200
SKAENHMSRW AARDVFELKQ FSQLPANIAV CTSKTHKEKM KGDISTRTKE CQPLSEGSIS
1210 1220 1230 1240 1250 1260
FPLYISHPVS QKKKKVCRID QTTFIIGETP KGIRRKQFEE MASYFKLSSV KEFAKRVTNA
1270 1280 1290 1300 1310 1320
TSEERQKMLR DFYTSQYPEV REFFVDSPSE CTKSASEKGE RVENKSEKRQ SLMKEQPSDS
1330 1340 1350 1360 1370 1380
ETLSFKNSTK KISPIFSPSI CKKKSIKFQN HSSCKKKVLS NDVETKKLPI SCTQETDGGE
1390 1400 1410 1420 1430 1440
RSQASEGTAA SCSLNSKSGA DELGKLENAG KGQQDLTSLG ISRNGPIFQV ENKTIENPVL
1450 1460 1470 1480 1490 1500
EDTSVVGLLG DTSILDDLFK SHENSPTQLP KKVLSGSIEK AKQRPKDFWD ILNDQNDDSL
1510 1520 1530 1540 1550
SKLTDLAVIE TLCEKVPFAA SSKRKEDLEA SLWKSNEKFL WKKFNSSDTD ESTANTQE