A3FPG8

PR
Gene name
GPAT4
Protein name
Glycerol-3-phosphate acyltransferase 4
Names
GPAT4, 1-acylglycerol-3-phosphate O-acyltransferase 6, 1-AGP acyltransferase 6, 1-AGPAT 6, Acyl-CoA:glycerol-3-phosphate acyltransferase 4, Lysophosphatidic acid acyltransferase zeta, LPAAT-zeta
Species
Bos taurus (Bovine)
KEGG Pathway
bta:511614
EC number
2.3.1.15: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-138 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3FPG8

Entry ID Method Resolution Chain Position Source
AF-A3FPG8-F1 Predicted AlphaFoldDB

No variants for A3FPG8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3FPG8

No associated diseases with A3FPG8

2 regional properties for A3FPG8

Type Name Position InterPro Accession
domain Phospholipid/glycerol acyltransferase 229 - 353 IPR002123
domain Lysophosphatidylcholine acyltransferase LPCAT1-like 218 - 427 IPR045252

Functions

Description
EC Number 2.3.1.15 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
glycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.
sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate.

1 GO annotations of biological process

Name Definition
CDP-diacylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZLL8 GPAT3 Glycerol-3-phosphate acyltransferase 3 Gallus gallus (Chicken) PR
Q8NF37 LPCAT1 Lysophosphatidylcholine acyltransferase 1 Homo sapiens (Human) PR
Q9Y679 AUP1 Lipid droplet-regulating VLDL assembly factor AUP1 Homo sapiens (Human) PR
Q86UL3 GPAT4 Glycerol-3-phosphate acyltransferase 4 Homo sapiens (Human) PR
Q8C0N2 Gpat3 Glycerol-3-phosphate acyltransferase 3 Mus musculus (Mouse) PR
Q8K2C8 Gpat4 Glycerol-3-phosphate acyltransferase 4 Mus musculus (Mouse) PR
Q8S8S2 LPEAT2 Lysophospholipid acyltransferase LPEAT2 Arabidopsis thaliana (Mouse-ear cress) PR
A3KGT9 agpat9l Glycerol-3-phosphate acyltransferase 3-like Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6PBN5 aup1 Lipid droplet-regulating VLDL assembly factor AUP1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MFLLLPFDSL IVSLLGISLT VLFTLLLVFI IVPAVFGVSF GIRKLYMKTL LKIFAWATLR
70 80 90 100 110 120
MERGAKEKNH QLYKPYTNGI IAKDPTSLEE EIKEIRRSGS SKALDNTPEF ELSDIFYFCR
130 140 150 160 170 180
KGMETIMDDE VTKRFSAEEL ESWNLLSRTN YNFQYISLRL TVLWGLGVLI RYCLLLSLRI
190 200 210 220 230 240
ALAFTGISLL VVGTTMVGYL PNGRFKEFLS KHVHLMCYRI CVRALTAIIT YHDRKNRPRN
250 260 270 280 290 300
GGICVANHTS PIDVIILASD GYYAMVGQVH GGLMGVIQRA MVKACPHVWF ERSEVKDRHL
310 320 330 340 350 360
VARRLTEHVQ DKSKLPILIF PEGTCINNTS VMMFKKGSFE IGATVYPVAI KYDPQFGDAF
370 380 390 400 410 420
WNSSKYGMVT YLLRMMTSWA IVCSVWYLPP MTRQAEEDAV QFANRVKSAI ARQGGLVDLL
430 440 450
WDGGLKREKV KDTFKEEQQK LYSKMIVGNH EDRSRS