A3FEM2

PR
Gene name
fev (pet1, zgc:158720)
Protein name
Protein FEV
Names
Protein Pet-1
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:791175
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3FEM2

Entry ID Method Resolution Chain Position Source
AF-A3FEM2-F1 Predicted AlphaFoldDB

No variants for A3FEM2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3FEM2

No associated diseases with A3FEM2

2 regional properties for A3FEM2

Type Name Position InterPro Accession
domain Protein kinase domain 24 - 274 IPR000719
binding_site Protein kinase, ATP binding site 30 - 53 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

5 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
hematopoietic stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

33 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A1A4L6 ETS2 Protein C-ets-2 Bos taurus (Bovine) SS
Q2KIC2 ETV1 ETS translocation variant 1 Bos taurus (Bovine) SS
P15062 ETS1 Transforming protein p68/c-ets-1 Gallus gallus (Chicken) SS
P10157 ETS2 Protein C-ets-2 Gallus gallus (Chicken) SS
Q90837 ERG Transcriptional regulator Erg Gallus gallus (Chicken) SS
A2T762 ETV3 ETS translocation variant 3 Pan troglodytes (Chimpanzee) PR
Q04688 Ets97D DNA-binding protein Ets97D Drosophila melanogaster (Fruit fly) PR
P50548 ERF ETS domain-containing transcription factor ERF Homo sapiens (Human) PR
P41970 ELK3 ETS domain-containing protein Elk-3 Homo sapiens (Human) SS
P41161 ETV5 ETS translocation variant 5 Homo sapiens (Human) SS
P43268 ETV4 ETS translocation variant 4 Homo sapiens (Human) EV
Q06546 GABPA GA-binding protein alpha chain Homo sapiens (Human) SS
P28324 ELK4 ETS domain-containing protein Elk-4 Homo sapiens (Human) EV
P15036 ETS2 Protein C-ets-2 Homo sapiens (Human) EV
P41162 ETV3 ETS translocation variant 3 Homo sapiens (Human) PR
P14921 ETS1 Protein C-ets-1 Homo sapiens (Human) EV
P50549 ETV1 ETS translocation variant 1 Homo sapiens (Human) EV
P11308 ERG Transcriptional regulator ERG Homo sapiens (Human) EV
P19419 ELK1 ETS domain-containing protein Elk-1 Homo sapiens (Human) EV
P41971 Elk3 ETS domain-containing protein Elk-3 Mus musculus (Mouse) EV
Q00422 Gabpa GA-binding protein alpha chain Mus musculus (Mouse) EV
P41969 Elk1 ETS domain-containing protein Elk-1 Mus musculus (Mouse) PR
P28322 Etv4 ETS translocation variant 4 Mus musculus (Mouse) SS
P15037 Ets2 Protein C-ets-2 Mus musculus (Mouse) SS
P27577 Ets1 Protein C-ets-1 Mus musculus (Mouse) EV
P70459 Erf ETS domain-containing transcription factor ERF Mus musculus (Mouse) PR
Q9CXC9 Etv5 ETS translocation variant 5 Mus musculus (Mouse) SS
P41158 Elk4 ETS domain-containing protein Elk-4 Mus musculus (Mouse) PR
P41164 Etv1 ETS translocation variant 1 Mus musculus (Mouse) SS
P81270 Erg Transcriptional regulator ERG Mus musculus (Mouse) SS
P41156 Ets1 Protein C-ets-1 Rattus norvegicus (Rat) SS
A4GTP4 Elk1 ETS domain-containing protein Elk-1 Rattus norvegicus (Rat) PR
Q9PUQ1 etv4 ETS translocation variant 4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MKAYPFTSTT ATTMRQNCGG SLMFNMYLSD PTENLLKESK SPSWTPINTG VQKGSGQIQL
70 80 90 100 110 120
WQFLLELLSD SANMTCIAWE GTNGEFKLID PDEVARRWGE RKSKPNMNYD KLSRALRYYY
130 140 150 160 170 180
DKNIMTKVHG KRYAYKFDFN GLAQVCQPSS TEQAIYKFQS NFAPIQFSGI SKLNLVAPGV
190 200 210 220 230
GPSGFSYWPG SPPTLYHSHN LQPPGPFGAV SASHLSCVNN INSLNNLNNI NNHYN