Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A3BYC1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A3BYC1-F1 | Predicted | AlphaFoldDB |
No variants for A3BYC1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A3BYC1 | |||||
No associated diseases with A3BYC1
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9XSK0 | CRX | Cone-rod homeobox protein | Bos taurus (Bovine) | PR |
| F1NEA7 | DMBX1 | Diencephalon/mesencephalon homeobox protein 1 | Gallus gallus (Chicken) | PR |
| Q90963 | PRRX2 | Paired mesoderm homeobox protein 2 | Gallus gallus (Chicken) | PR |
| Q8SQ03 | CRX | Cone-rod homeobox protein | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q03014 | HHEX | Hematopoietically-expressed homeobox protein HHEX | Homo sapiens (Human) | PR |
| O14813 | PHOX2A | Paired mesoderm homeobox protein 2A | Homo sapiens (Human) | PR |
| P32243 | OTX2 | Homeobox protein OTX2 | Homo sapiens (Human) | PR |
| O95076 | ALX3 | Homeobox protein aristaless-like 3 | Homo sapiens (Human) | PR |
| O43186 | CRX | Cone-rod homeobox protein | Homo sapiens (Human) | PR |
| Q62066 | Phox2a | Paired mesoderm homeobox protein 2A | Mus musculus (Mouse) | PR |
| P80206 | Otx2 | Homeobox protein OTX2 | Mus musculus (Mouse) | PR |
| O54751 | Crx | Cone-rod homeobox protein | Mus musculus (Mouse) | PR |
| Q62782 | Phox2a | Paired mesoderm homeobox protein 2A | Rattus norvegicus (Rat) | PR |
| Q5VPE5 | HOX28 | Homeobox-leucine zipper protein HOX28 | Oryza sativa subsp japonica (Rice) | PR |
| Q6H6S3 | HOX24 | Homeobox-leucine zipper protein HOX24 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XUJ5 | HOX22 | Homeobox-leucine zipper protein HOX22 | Oryza sativa subsp japonica (Rice) | PR |
| P46603 | HAT9 | Homeobox-leucine zipper protein HAT9 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M276 | ATHB-12 | Homeobox-leucine zipper protein ATHB-12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FN29 | ATHB-52 | Homeobox-leucine zipper protein ATHB-52 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q28FN6 | otx2 | Homeobox protein OTX2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6F2E2 | vex1 | Homeobox protein vex1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q566X8 | dmbx1b | Diencephalon/mesencephalon homeobox protein 1-B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q91994 | otx1b | Homeobox protein OTX1 B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAASSEVSID | PDQWFYIYSL | ERVAYVCERV | GSPVMEEAEL | RRRRRKRPFL | TTTHDELELQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MEDLVDELYG | VDEQGSSSAA | ARKRRLTAEQ | VRALERSFEE | EKRKLEPERK | SELARRLGIA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PRQVAVWFQN | RRARWKTKQL | ELDFDRLRAA | HDELLAGRTA | LAADNESLRS | QVILLTEKLQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ANGKSPSPSP | APAEQTAVPA | APESAKSFQL | EEGRRLYDAA | GSTTTTNGGG | GGVAMPAARV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AAARAASNDS | PESYFAGARS | PPSSSEDDCG | GAGSDDDYPS | SSVLLPVDAT | LVGDAFEHAV |
| 310 | |||||
| AATVAADEEA | PLNSWEWFWN |