A2VDV2

SS
Gene name
STK38
Protein name
Serine/threonine-protein kinase 38
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:533677
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

STK38, called nuclear Dbf2-related kinase 1 (NDR1 protein kinase), is a subclass of the AGC family of protein kinases that are involved in the regulation of cell division and cell morphology. NDR kinase activity is regulated by phosphorylation and by the Ca2+-binding protein, S100B. MOB1 also stimulates NDR kinase activity and interacts with NDR. <br> A common feature of the NDR family of kinases is an insert in the catalytic domain of 30 - 60 amino acids between subdomains VII and VIII. The insert sequence is not highly conserved but contains in all cases many positively charged amino acids. Mutations of the residues within the insert (autoinhibitory element) increase kinase activity and the binding of MOB1 or S100B to the N-terminal domain (SMA domain) of NDR induces the release of autoinhibition.

Autoinhibitory domains (AIDs)

265-276 (Autoinhibitory segment) SS

Target domain

89-382 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

229-241 (Activation loop from InterPro)

Target domain

89-382 (Protein kinase domain)

Relief mechanism

Assay

278-287 (Activation loop from InterPro)

Target domain

89-382 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for A2VDV2

Entry ID Method Resolution Chain Position Source
AF-A2VDV2-F1 Predicted AlphaFoldDB

56 variants for A2VDV2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs455453960 13 S>I No Ensembl
rs443026130 21 T>M No Ensembl
rs439077037 30 F>L No Ensembl
rs799819237 63 R>G No Ensembl
rs469150419 64 L>P No Ensembl
rs464768642 68 A>S No Ensembl
rs450670333 68 A>V No Ensembl
rs465085368 76 F>I No Ensembl
rs479189699 82 T>K No Ensembl
rs460815263 91 S>P No Ensembl
rs442360891 106 V>F No Ensembl
rs443630178 110 D>E No Ensembl
rs475681996 111 T>K No Ensembl
rs457208176 113 H>P No Ensembl
rs465459434 144 A>G No Ensembl
rs441095151 158 D>H No Ensembl
rs473795185 158 D>V No Ensembl
rs450137679 167 E>D No Ensembl
rs440248931 285 T>P No Ensembl
rs454685694 286 P>T No Ensembl
rs475443657 289 I>S No Ensembl
rs432103044 292 E>* No Ensembl
rs464747021 292 E>G No Ensembl
rs452838166 295 M>L No Ensembl
rs435038748 314 E>D No Ensembl
rs459532784 327 P>T No Ensembl
rs441099827 329 E>D No Ensembl
rs463464818 341 L>W No Ensembl
rs445134978 342 T>N No Ensembl
rs478047868 352 K>E No Ensembl
rs461713201 358 L>F No Ensembl
rs443220552 359 R>G No Ensembl
rs447468371 368 I>M No Ensembl
rs480501453 374 E>Q No Ensembl
rs461823580 375 E>D No Ensembl
rs443384048 381 F>I No Ensembl
rs457732240 384 G>C No Ensembl
rs457732240 384 G>S No Ensembl
rs439848299 385 V>F No Ensembl
rs472949629 386 D>A No Ensembl
rs454221968 387 W>C No Ensembl
rs435781169 387 W>R No Ensembl
rs468805918 389 H>D No Ensembl
rs463758368 399 I>S No Ensembl
rs444281499 408 S>T No Ensembl
rs470890770 409 N>K No Ensembl
rs452254470 410 F>L No Ensembl
rs440172352 410 F>Y No Ensembl
rs473049148 411 D>H No Ensembl
rs473049148 411 D>Y No Ensembl
rs454474075 413 F>C No Ensembl
rs436051703 415 E>* No Ensembl
rs468763780 415 E>D No Ensembl
rs436051703 415 E>K No Ensembl
rs456787172 417 D>Y No Ensembl
rs435043977 424 A>E No Ensembl

No associated diseases with A2VDV2

5 regional properties for A2VDV2

Type Name Position InterPro Accession
domain Protein kinase domain 89 - 382 IPR000719
domain AGC-kinase, C-terminal 383 - 455 IPR000961
active_site Serine/threonine-protein kinase, active site 208 - 220 IPR008271
binding_site Protein kinase, ATP binding site 95 - 118 IPR017441
domain Protein kinase, C-terminal 401 - 445 IPR017892

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

3 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of MAP kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53894 CBK1 Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
A1A4I4 PKN1 Serine/threonine-protein kinase N1 Bos taurus (Bovine) SS
P04409 PRKCA Protein kinase C alpha type Bos taurus (Bovine) EV SS
P05128 PRKCG Protein kinase C gamma type Bos taurus (Bovine) SS
P05126 PRKCB Protein kinase C beta type Bos taurus (Bovine) SS
Q9NBK5 trc Serine/threonine-protein kinase tricornered Drosophila melanogaster (Fruit fly) SS
Q96LW2 RSKR Ribosomal protein S6 kinase-related protein Homo sapiens (Human) PR
Q9Y2H1 STK38L Serine/threonine-protein kinase 38-like Homo sapiens (Human) EV
Q15208 STK38 Serine/threonine-protein kinase 38 Homo sapiens (Human) EV
Q7TSE6 Stk38l Serine/threonine-protein kinase 38-like Mus musculus (Mouse) SS
Q91VJ4 Stk38 Serine/threonine-protein kinase 38 Mus musculus (Mouse) SS
Q2L6W9 sax-1 Serine/threonine-protein kinase sax-1 Caenorhabditis elegans SS
10 20 30 40 50 60
MAMTGSTPCS SMSSHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEK VMEEEGLKDE
70 80 90 100 110 120
EKRLRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL
130 140 150 160 170 180
RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK
190 200 210 220 230 240
KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA
250 260 270 280 290 300
HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN
310 320 330 340 350 360
KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPIS EKAKDLILRF
370 380 390 400 410 420
CCEWEHRIGA PGVEEIKNNS FFEGVDWEHI RERPAAISIE IKSIDDTSNF DEFPESDILK
430 440 450 460
PTVATSNHPD TDYKNKDWVF INYTYKRFEG LTARGAIPSY MKAAK