A2T762
PR
Gene name |
ETV3 |
Protein name |
ETS translocation variant 3 |
Names |
|
Species |
Pan troglodytes (Chimpanzee) |
KEGG Pathway |
ptr:457412 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2T762
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2T762-F1 | Predicted | AlphaFoldDB |
No variants for A2T762
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2T762 | |||||
No associated diseases with A2T762
11 regional properties for A2T762
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | FERM domain | 39 - 359 | IPR000299 |
| domain | Protein kinase domain | 425 - 683 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 426 - 678 | IPR001245 |
| domain | Focal adhesion kinase, targeting (FAT) domain | 870 - 1001 | IPR005189 |
| active_site | Tyrosine-protein kinase, active site | 545 - 557 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 431 - 457 | IPR017441 |
| domain | FERM central domain | 145 - 254 | IPR019748 |
| domain | Band 4.1 domain | 35 - 265 | IPR019749 |
| domain | Tyrosine-protein kinase, catalytic domain | 425 - 679 | IPR020635 |
| domain | Focal adhesion kinase, N-terminal | 39 - 137 | IPR041390 |
| domain | FAK1/PYK2, FERM domain C-lobe | 261 - 368 | IPR041784 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| DNA-binding transcription repressor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
33 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A1A4L6 | ETS2 | Protein C-ets-2 | Bos taurus (Bovine) | SS |
| Q2KIC2 | ETV1 | ETS translocation variant 1 | Bos taurus (Bovine) | SS |
| P15062 | ETS1 | Transforming protein p68/c-ets-1 | Gallus gallus (Chicken) | SS |
| P10157 | ETS2 | Protein C-ets-2 | Gallus gallus (Chicken) | SS |
| Q90837 | ERG | Transcriptional regulator Erg | Gallus gallus (Chicken) | SS |
| Q04688 | Ets97D | DNA-binding protein Ets97D | Drosophila melanogaster (Fruit fly) | PR |
| P50548 | ERF | ETS domain-containing transcription factor ERF | Homo sapiens (Human) | PR |
| P41970 | ELK3 | ETS domain-containing protein Elk-3 | Homo sapiens (Human) | SS |
| P41161 | ETV5 | ETS translocation variant 5 | Homo sapiens (Human) | SS |
| P43268 | ETV4 | ETS translocation variant 4 | Homo sapiens (Human) | EV |
| Q06546 | GABPA | GA-binding protein alpha chain | Homo sapiens (Human) | SS |
| P28324 | ELK4 | ETS domain-containing protein Elk-4 | Homo sapiens (Human) | EV |
| P15036 | ETS2 | Protein C-ets-2 | Homo sapiens (Human) | EV |
| P14921 | ETS1 | Protein C-ets-1 | Homo sapiens (Human) | EV |
| P50549 | ETV1 | ETS translocation variant 1 | Homo sapiens (Human) | EV |
| P11308 | ERG | Transcriptional regulator ERG | Homo sapiens (Human) | EV |
| P19419 | ELK1 | ETS domain-containing protein Elk-1 | Homo sapiens (Human) | EV |
| P41162 | ETV3 | ETS translocation variant 3 | Homo sapiens (Human) | PR |
| P41971 | Elk3 | ETS domain-containing protein Elk-3 | Mus musculus (Mouse) | EV |
| Q00422 | Gabpa | GA-binding protein alpha chain | Mus musculus (Mouse) | EV |
| P41969 | Elk1 | ETS domain-containing protein Elk-1 | Mus musculus (Mouse) | PR |
| P28322 | Etv4 | ETS translocation variant 4 | Mus musculus (Mouse) | SS |
| P15037 | Ets2 | Protein C-ets-2 | Mus musculus (Mouse) | SS |
| P27577 | Ets1 | Protein C-ets-1 | Mus musculus (Mouse) | EV |
| P70459 | Erf | ETS domain-containing transcription factor ERF | Mus musculus (Mouse) | PR |
| Q9CXC9 | Etv5 | ETS translocation variant 5 | Mus musculus (Mouse) | SS |
| P41158 | Elk4 | ETS domain-containing protein Elk-4 | Mus musculus (Mouse) | PR |
| P41164 | Etv1 | ETS translocation variant 1 | Mus musculus (Mouse) | SS |
| P81270 | Erg | Transcriptional regulator ERG | Mus musculus (Mouse) | SS |
| P41156 | Ets1 | Protein C-ets-1 | Rattus norvegicus (Rat) | SS |
| A4GTP4 | Elk1 | ETS domain-containing protein Elk-1 | Rattus norvegicus (Rat) | PR |
| Q9PUQ1 | etv4 | ETS translocation variant 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A3FEM2 | fev | Protein FEV | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKAGCSIVEK | PEGGGGYQFP | DWAYKTESSP | GSRQIQLWHF | ILELLQKEEF | RHVIAWQQGE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YGEFVIKDPD | EVARLWGRRK | CKPQMNYDKL | SRALRYYYNK | RILHKTKGKR | FTYKFNFNKL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VMPNYPFINI | RSSGVVPQSA | PPVPTASSRF | HFPPLDTHSP | TNDVQPGRFS | ASSLTASGQE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSNGTDRKTE | LSELEDGSAA | DWRRGVDPMS | SRNAIGGGGI | GHQKRKPDIM | LPLFARPGMY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PDPHSPFAVS | PIPGRGGVLN | VPISPALSLT | PTIFSYSPSP | GLSPFTSSSC | FSFNPEEMKH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YLHSQACSVF | NYHLSPRTFP | RYPGLMVPPL | QCQMHPEEST | QFSIKLQPPP | VGRKNRERVE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSEESAPVTT | PTMASIPPRI | KVEPASEKDP | ESLRQSAREK | EEHTQEEGTV | PSRTIEEEKG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TIFARPAAPP | IWPSVPISTP | SEEPLEVTED | IEDRPGKEPS | APEKKEDALM | PPKLRLKRRW |
| 490 | 500 | 510 | |||
| NDDPEARELS | KSGKFLWNGS | GPQGLATAAA | DA |