A2RUV0
SS
Gene name |
notch1 |
Protein name |
Neurogenic locus notch homolog protein 1 |
Names |
Notch 1 [Cleaved into: Notch 1 extracellular truncation , NEXT; Notch 1 intracellular domain , NICD] |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:100037842 |
EC number |
|
Protein Class |
|
Descriptions
NOTCH1 is a neurogenic locus notch homolog protein 1 and belongs to the NOTCH family of proteins that regulate cell growth, proliferation, differentiation and apoptosis in both embryonic and adult tissues. The negative regulatory region (NRR) of NOTCH1 contains three Lin12/Notch repeats (LNR-A, LNR-B, and LNR-C). The LNR-C hydrophobic residues pack against the heterodimerization (HD) domain core. In addition, the LNR-B, the linker between LNR-A and LNR-B, and the C-terminus of LNR-A wrap around the HD domain, thus masking the metalloprotease site (S2) and preventing exposure to receptor activation. For the activation of NOTCH1, the LNR-A, LNR-AB linker, and LNR-B must be removed.
Autoinhibitory domains (AIDs)
Target domain |
1561-1720 (HD domain) |
Relief mechanism |
Cleavage |
Assay |
|
Accessory elements
No accessory elements
References
- Gordon WR et al. (2007) "Structural basis for autoinhibition of Notch", Nature structural & molecular biology, 14, 295-300
- Tiyanont K et al. (2011) "Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation", Structure (London, England : 1993), 19, 546-54
- Gordon WR et al. (2009) "Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL", Blood, 113, 4381-90
Autoinhibited structure
Activated structure
1 structures for A2RUV0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2RUV0-F1 | Predicted | AlphaFoldDB |
No variants for A2RUV0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2RUV0 | |||||
No associated diseases with A2RUV0
4 regional properties for A2RUV0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | DNA methylase, C-5 cytosine-specific, active site | 530 - 542 | IPR018117 |
| domain | ADD domain | 309 - 441 | IPR025766 |
| domain | DNMT3, cysteine rich ADD domain, GATA1-like zinc finger | 302 - 357 | IPR040552 |
| domain | DNMT3, ADD domain, PHD zinc finger | 364 - 413 | IPR049554 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| Notch binding | Binding to a Notch (N) protein, a surface receptor. |
| signaling receptor activity | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| Notch signaling involved in heart development | The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time. |
| regulation of developmental process | Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q868Z9 | Ppn | Papilin | Drosophila melanogaster (Fruit fly) | SS |
| Q04721 | NOTCH2 | Neurogenic locus notch homolog protein 2 | Homo sapiens (Human) | EV |
| P21941 | MATN1 | Cartilage matrix protein | Homo sapiens (Human) | PR |
| P46531 | NOTCH1 | Neurogenic locus notch homolog protein 1 | Homo sapiens (Human) | EV |
| Q6GUQ1 | Egfl8 | Epidermal growth factor-like protein 8 | Mus musculus (Mouse) | PR |
| Q91V88 | Npnt | Nephronectin | Mus musculus (Mouse) | PR |
| O35516 | Notch2 | Neurogenic locus notch homolog protein 2 | Mus musculus (Mouse) | SS |
| P51942 | Matn1 | Cartilage matrix protein | Mus musculus (Mouse) | PR |
| Q01705 | Notch1 | Neurogenic locus notch homolog protein 1 | Mus musculus (Mouse) | SS |
| Q9QW30 | Notch2 | Neurogenic locus notch homolog protein 2 | Rattus norvegicus (Rat) | SS |
| Q07008 | Notch1 | Neurogenic locus notch homolog protein 1 | Rattus norvegicus (Rat) | SS |
| P13508 | glp-1 | Protein glp-1 | Caenorhabditis elegans | EV |
| P46530 | notch1a | Neurogenic locus notch homolog protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYRIGLLVLI | WSLLGLAQGL | RCTQTAEMCL | NGGRCEMTPG | GTGVCLCSSS | YFGERCQYPN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PCALKNQCMN | FGTCEPVLLG | NAIDFTCHCP | VGFTDKVCLT | PVDNACVNNP | CRNGGTCELL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSVSDYRCRC | PPGWTGDSCQ | QADPCASNPC | ANGGKCLPFE | TQYICKCPSG | FHGATCKQDI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NECSQNPCRN | GGQCLNEFGS | YRCNCQNRFT | GRNCEEPYVP | CNPSPCLNGG | TCRQTDDTSY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ECTCLPGFSG | QNCEENIDDC | PSNNCRNGGT | CVDGVNTYNC | QCPPDWTGQY | CTEDVDECQL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MPNACQNGGT | CHNTYGGYNC | VCVNGWTGED | CSENIDDCAN | AACHSGATCH | DRVASFFCEC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PHGRTGLLCH | LDNACISNPC | NEGSNCDTNP | VNGKAICTCP | PGYTGPACNN | DVDECSLGAN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PCEHGGRCTN | TLGSFQCNCP | QGYAGPRCEI | DVNECLSNPC | QNDATCLDQI | GEFQCICMPG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YEGLYCETNI | DECASNPCLH | NGKCVDKINE | FHCECPTGFN | GNLCQHDVDE | CASTPCKNGA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KCLDGPNSYT | CQCTEGFTGR | HCEQDINECI | PDPCHYGTCK | DGIATFTCLC | RPGYTGRLCD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NDINECLSQP | CQNGGQCTDR | ENGYICTCPK | GTTGVNCETN | LDDCASNPCD | YGKCIDKIDG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YECTCEPGYT | GKMCNINIDE | CASNPCRNGG | TCKDKINGFT | CVCPDGYHDH | MCLSEVNECN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SNPCIHGTCH | DGINGYKCDC | DAGWSGSNCD | VNNNECESNP | CMNGGTCKDM | TGAYICTCRA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GFSGPNCQTN | INECASNPCL | NRGTCIDDVA | GYKCNCMLPY | TGAICEAVLA | PCSGSPCKNG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GRCKESEDYE | TFSCECPPGW | QGQTCEIDMN | ECVNRPCRNG | AMCQNTNGSY | KCNCKPGYAG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| RHCETDIDDC | QPNPCHNGGS | CSDGINMFFC | NCPAGFRGPK | CEEDINECAS | NPCKNGANCT |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| DCVNSYTCTC | QPGFSGIHCE | NNTPDCTESS | CFNGGTCIDG | INTFSCQCPP | GFTGNYCQHD |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| INECDSKPCL | NGGTCQDSYG | AYKCTCPQGY | TGLNCQNLVR | WCDSSPCKNG | GKCWQTNNFY |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| RCECKSGWTG | VYCDVPSVSC | EVAAKQQGVD | IAHLCRNSGM | CVDTGNTHFC | RCQAGYTGSY |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| CEEQVDECSP | NPCQNGATCT | DYLGGYSCEC | VAGYHGVNCS | EEINECLSHP | CHNGGTCIDL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| INTYKCSCPR | GTQGVHCEIN | VDDCTPFYDS | VSLEPKCFNN | GKCFDRVGGY | NCICPPGFVG |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| ERCEGDVNEC | LSNPCDPRGT | QNCIQLVNDY | RCECRQGFTG | RRCDSVVDGC | KGLPCRNGGT |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| CAVASNTERG | FICKCPPGFD | GATCEYDART | CGNLRCQNGG | TCISVLKSSK | CVCSEGYTGA |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| TCQYPVVSPC | ASRPCYNGGT | CQFSPEEPFF | QCFCPTNFNG | LFCHILDYGF | IGGLGKNITP |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| PDNEEICENE | QCAELADNKI | CNANCNNHAC | GWDGGDCSLN | FNDPWKNCTQ | SLQCWKYFND |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| GKCDSQCNNS | GCLYDGFDCQ | KVEVQCNPLY | DQYCRDHFQD | GHCDQGCNNA | ECEWDGLDCD |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| NMPENLAEGT | LLIVVLMPPE | KLKNNSVNFL | RELSRVLHTN | VVFKKDSKGE | YKIYPYYGNE |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| EELKKHHIKK | RSAASWSDAP | TAIFSTMKES | VLPGRRRREL | DQMEVRGSIV | YLEIDNRQCY |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| KSSSQCFTSA | TDVAAFLGAL | ATHGNLNIPY | KIEAVKSEIV | ETAKPPPPLY | AMFSMLVIPL |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| LIIFVIMVVI | VNKKRRREHG | QLWFPEGFIP | KEPSKKKRRE | PLGEDSVGLK | PLKNLTDGSF |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| MDDNQNEWGD | EETLENKRFR | FEEQVMLPEL | VDDQTDHRQW | TQQHLDAADL | RIPSMAPTPP |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| QGEIDADCMD | VNVRGPDGFT | PLMIAACSGG | GLETGNSEEE | EDASANMISD | FIGQGAQLHN |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| QTDRTGETAL | HLAARYARAD | AAKRLLESSA | DANVPDNMGR | TPLHAAVAAD | AQGVFQILIR |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| NRATDLDARM | CDGTTPLILA | ARLAVEGMVE | ELINAHADVN | AVDEFGKSAL | HWAAAVNNVD |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| AAAVLLKSSA | NKDMQNNKEE | TPLFLAAREG | SYETAKVLLD | HYANRDITDH | MDRLPRDIAQ |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| ERMHHDIVHL | LDEHNLVKSP | TLHGGPLGAP | TLSPPICSPN | GYMGNMKPSV | QSKKARKPSI |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| KGNGCKEAKE | LKARRKKSQD | GKTSLLDSGS | SGVLSPVDSL | ESPHGYLSDV | ASPPLMTSPF |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| QQSPSMPLNH | LTSMQDSHLG | LNHMTMANKQ | EMASNRMAFD | GMTPRLTHLN | VSSPNTIMTN |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| GSMHFTVGGA | PAMNGQCDWF | ARLQNGMVQN | QYNPIRNGIQ | QGNAQQALQH | GLMSSLHNGL |
| 2350 | 2360 | 2370 | 2380 | 2390 | 2400 |
| PATTLSQMMT | YQAMPNTRMA | NQPHLMQAQQ | MQQQQNLQLH | QSVQQQQHQN | SNATSTHIGS |
| 2410 | 2420 | 2430 | 2440 | 2450 | 2460 |
| PFCSNDISQT | DLQQMSGNNI | HSVMPQDTQI | FTNSLPPTLT | QSMATTQFLT | PPSQHSYSSP |
| 2470 | 2480 | 2490 | 2500 | 2510 | 2520 |
| MDNTPSHQLQ | VPDHPFLTPS | PESPDQWSSS | SPHSNMSDWS | EGISSPPTSM | QPQRTHIPEA |
| FK |