A2RUV0

SS
Gene name
notch1
Protein name
Neurogenic locus notch homolog protein 1
Names
Notch 1 [Cleaved into: Notch 1 extracellular truncation , NEXT; Notch 1 intracellular domain , NICD]
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:100037842
EC number
Protein Class

Descriptions

NOTCH1 is a neurogenic locus notch homolog protein 1 and belongs to the NOTCH family of proteins that regulate cell growth, proliferation, differentiation and apoptosis in both embryonic and adult tissues. The negative regulatory region (NRR) of NOTCH1 contains three Lin12/Notch repeats (LNR-A, LNR-B, and LNR-C). The LNR-C hydrophobic residues pack against the heterodimerization (HD) domain core. In addition, the LNR-B, the linker between LNR-A and LNR-B, and the C-terminus of LNR-A wrap around the HD domain, thus masking the metalloprotease site (S2) and preventing exposure to receptor activation. For the activation of NOTCH1, the LNR-A, LNR-AB linker, and LNR-B must be removed.

Autoinhibitory domains (AIDs)

1447-1568 (LNR-A, B, and C) SS

Target domain

1561-1720 (HD domain)

Relief mechanism

Cleavage

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2RUV0

Entry ID Method Resolution Chain Position Source
AF-A2RUV0-F1 Predicted AlphaFoldDB

No variants for A2RUV0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A2RUV0

No associated diseases with A2RUV0

117 regional properties for A2RUV0

Type Name Position InterPro Accession
ptm EGF-type aspartate/asparagine hydroxylation site 194 - 205 IPR000152-1
ptm EGF-type aspartate/asparagine hydroxylation site 271 - 282 IPR000152-2
ptm EGF-type aspartate/asparagine hydroxylation site 311 - 322 IPR000152-3
ptm EGF-type aspartate/asparagine hydroxylation site 349 - 360 IPR000152-4
ptm EGF-type aspartate/asparagine hydroxylation site 428 - 439 IPR000152-5
ptm EGF-type aspartate/asparagine hydroxylation site 466 - 477 IPR000152-6
ptm EGF-type aspartate/asparagine hydroxylation site 504 - 515 IPR000152-7
ptm EGF-type aspartate/asparagine hydroxylation site 542 - 553 IPR000152-8
ptm EGF-type aspartate/asparagine hydroxylation site 579 - 590 IPR000152-9
ptm EGF-type aspartate/asparagine hydroxylation site 617 - 628 IPR000152-10
ptm EGF-type aspartate/asparagine hydroxylation site 654 - 665 IPR000152-11
ptm EGF-type aspartate/asparagine hydroxylation site 692 - 703 IPR000152-12
ptm EGF-type aspartate/asparagine hydroxylation site 729 - 740 IPR000152-13
ptm EGF-type aspartate/asparagine hydroxylation site 767 - 778 IPR000152-14
ptm EGF-type aspartate/asparagine hydroxylation site 805 - 816 IPR000152-15
ptm EGF-type aspartate/asparagine hydroxylation site 883 - 894 IPR000152-16
ptm EGF-type aspartate/asparagine hydroxylation site 921 - 932 IPR000152-17
ptm EGF-type aspartate/asparagine hydroxylation site 959 - 970 IPR000152-18
ptm EGF-type aspartate/asparagine hydroxylation site 997 - 1008 IPR000152-19
ptm EGF-type aspartate/asparagine hydroxylation site 1035 - 1046 IPR000152-20
ptm EGF-type aspartate/asparagine hydroxylation site 1159 - 1170 IPR000152-21
ptm EGF-type aspartate/asparagine hydroxylation site 1197 - 1208 IPR000152-22
ptm EGF-type aspartate/asparagine hydroxylation site 1243 - 1254 IPR000152-23
domain EGF-like domain 18 - 57 IPR000742-1
domain EGF-like domain 58 - 99 IPR000742-2
domain EGF-like domain 102 - 140 IPR000742-3
domain EGF-like domain 141 - 177 IPR000742-4
domain EGF-like domain 179 - 215 IPR000742-5
domain EGF-like domain 217 - 254 IPR000742-6
domain EGF-like domain 256 - 292 IPR000742-7
domain EGF-like domain 294 - 332 IPR000742-8
domain EGF-like domain 334 - 370 IPR000742-9
domain EGF-like domain 371 - 409 IPR000742-10
domain EGF-like domain 411 - 449 IPR000742-11
domain EGF-like domain 451 - 487 IPR000742-12
domain EGF-like domain 489 - 525 IPR000742-13
domain EGF-like domain 527 - 563 IPR000742-14
domain EGF-like domain 565 - 600 IPR000742-15
domain EGF-like domain 602 - 638 IPR000742-16
domain EGF-like domain 640 - 675 IPR000742-17
domain EGF-like domain 677 - 713 IPR000742-18
domain EGF-like domain 715 - 750 IPR000742-19
domain EGF-like domain 752 - 788 IPR000742-20
domain EGF-like domain 790 - 826 IPR000742-21
domain EGF-like domain 828 - 866 IPR000742-22
domain EGF-like domain 868 - 904 IPR000742-23
domain EGF-like domain 906 - 942 IPR000742-24
domain EGF-like domain 944 - 980 IPR000742-25
domain EGF-like domain 982 - 1018 IPR000742-26
domain EGF-like domain 1020 - 1056 IPR000742-27
domain EGF-like domain 1058 - 1094 IPR000742-28
domain EGF-like domain 1099 - 1142 IPR000742-29
domain EGF-like domain 1144 - 1180 IPR000742-30
domain EGF-like domain 1182 - 1218 IPR000742-31
domain EGF-like domain 1220 - 1264 IPR000742-32
domain EGF-like domain 1266 - 1304 IPR000742-33
domain EGF-like domain 1306 - 1345 IPR000742-34
domain EGF-like domain 1347 - 1383 IPR000742-35
domain EGF-like domain 1386 - 1424 IPR000742-36
domain Notch domain 1440 - 1564 IPR000800
domain EGF-like calcium-binding domain 60 - 99 IPR001881-1
domain EGF-like calcium-binding domain 104 - 140 IPR001881-2
domain EGF-like calcium-binding domain 141 - 177 IPR001881-3
domain EGF-like calcium-binding domain 179 - 215 IPR001881-4
domain EGF-like calcium-binding domain 221 - 254 IPR001881-5
domain EGF-like calcium-binding domain 256 - 292 IPR001881-6
domain EGF-like calcium-binding domain 294 - 332 IPR001881-7
domain EGF-like calcium-binding domain 334 - 370 IPR001881-8
domain EGF-like calcium-binding domain 411 - 449 IPR001881-9
domain EGF-like calcium-binding domain 451 - 487 IPR001881-10
domain EGF-like calcium-binding domain 489 - 525 IPR001881-11
domain EGF-like calcium-binding domain 527 - 563 IPR001881-12
domain EGF-like calcium-binding domain 565 - 600 IPR001881-13
domain EGF-like calcium-binding domain 602 - 638 IPR001881-14
domain EGF-like calcium-binding domain 640 - 675 IPR001881-15
domain EGF-like calcium-binding domain 677 - 713 IPR001881-16
domain EGF-like calcium-binding domain 715 - 750 IPR001881-17
domain EGF-like calcium-binding domain 752 - 788 IPR001881-18
domain EGF-like calcium-binding domain 790 - 826 IPR001881-19
domain EGF-like calcium-binding domain 832 - 866 IPR001881-20
domain EGF-like calcium-binding domain 868 - 904 IPR001881-21
domain EGF-like calcium-binding domain 906 - 942 IPR001881-22
domain EGF-like calcium-binding domain 944 - 980 IPR001881-23
domain EGF-like calcium-binding domain 982 - 1018 IPR001881-24
domain EGF-like calcium-binding domain 1020 - 1056 IPR001881-25
domain EGF-like calcium-binding domain 1062 - 1094 IPR001881-26
domain EGF-like calcium-binding domain 1100 - 1142 IPR001881-27
domain EGF-like calcium-binding domain 1144 - 1180 IPR001881-28
domain EGF-like calcium-binding domain 1182 - 1218 IPR001881-29
domain EGF-like calcium-binding domain 1220 - 1264 IPR001881-30
domain EGF-like calcium-binding domain 1266 - 1304 IPR001881-31
domain EGF-like calcium-binding domain 1307 - 1345 IPR001881-32
domain EGF-like calcium-binding domain 1347 - 1383 IPR001881-33
repeat Ankyrin repeat 1877 - 1988 IPR002110-1
repeat Ankyrin repeat 1992 - 2090 IPR002110-2
domain Notch, NOD domain 1563 - 1619 IPR010660
domain Notch, NODP domain 1664 - 1726 IPR011656
conserved_site EGF-like, conserved site 574 - 594 IPR013032-1
conserved_site EGF-like, conserved site 686 - 707 IPR013032-2
conserved_site EGF-like, conserved site 724 - 744 IPR013032-3
conserved_site EGF-like, conserved site 953 - 974 IPR013032-4
conserved_site EGF-like, conserved site 991 - 1012 IPR013032-5
conserved_site EGF-like, conserved site 1283 - 1298 IPR013032-6
conserved_site EGF-like calcium-binding, conserved site 179 - 203 IPR018097-1
conserved_site EGF-like calcium-binding, conserved site 294 - 320 IPR018097-2
conserved_site EGF-like calcium-binding, conserved site 451 - 475 IPR018097-3
conserved_site EGF-like calcium-binding, conserved site 527 - 551 IPR018097-4
conserved_site EGF-like calcium-binding, conserved site 640 - 663 IPR018097-5
conserved_site EGF-like calcium-binding, conserved site 677 - 701 IPR018097-6
conserved_site EGF-like calcium-binding, conserved site 868 - 892 IPR018097-7
conserved_site EGF-like calcium-binding, conserved site 1020 - 1044 IPR018097-8
conserved_site EGF-like calcium-binding, conserved site 1144 - 1168 IPR018097-9
conserved_site EGF-like calcium-binding, conserved site 1220 - 1252 IPR018097-10
domain Notch, C-terminal 2445 - 2508 IPR024600
domain NOTCH1 EGF-like calcium-binding domain 294 - 328 IPR049883-1
domain NOTCH1 EGF-like calcium-binding domain 411 - 444 IPR049883-2
domain NOTCH1 EGF-like calcium-binding domain 868 - 899 IPR049883-3

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
Notch binding Binding to a Notch (N) protein, a surface receptor.
signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

6 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
Notch signaling involved in heart development The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time.
regulation of developmental process Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q868Z9 Ppn Papilin Drosophila melanogaster (Fruit fly) SS
Q04721 NOTCH2 Neurogenic locus notch homolog protein 2 Homo sapiens (Human) EV
P21941 MATN1 Cartilage matrix protein Homo sapiens (Human) PR
P46531 NOTCH1 Neurogenic locus notch homolog protein 1 Homo sapiens (Human) EV
Q6GUQ1 Egfl8 Epidermal growth factor-like protein 8 Mus musculus (Mouse) PR
Q91V88 Npnt Nephronectin Mus musculus (Mouse) PR
O35516 Notch2 Neurogenic locus notch homolog protein 2 Mus musculus (Mouse) SS
P51942 Matn1 Cartilage matrix protein Mus musculus (Mouse) PR
Q01705 Notch1 Neurogenic locus notch homolog protein 1 Mus musculus (Mouse) SS
Q9QW30 Notch2 Neurogenic locus notch homolog protein 2 Rattus norvegicus (Rat) SS
Q07008 Notch1 Neurogenic locus notch homolog protein 1 Rattus norvegicus (Rat) SS
P13508 glp-1 Protein glp-1 Caenorhabditis elegans EV
P46530 notch1a Neurogenic locus notch homolog protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MYRIGLLVLI WSLLGLAQGL RCTQTAEMCL NGGRCEMTPG GTGVCLCSSS YFGERCQYPN
70 80 90 100 110 120
PCALKNQCMN FGTCEPVLLG NAIDFTCHCP VGFTDKVCLT PVDNACVNNP CRNGGTCELL
130 140 150 160 170 180
SSVSDYRCRC PPGWTGDSCQ QADPCASNPC ANGGKCLPFE TQYICKCPSG FHGATCKQDI
190 200 210 220 230 240
NECSQNPCRN GGQCLNEFGS YRCNCQNRFT GRNCEEPYVP CNPSPCLNGG TCRQTDDTSY
250 260 270 280 290 300
ECTCLPGFSG QNCEENIDDC PSNNCRNGGT CVDGVNTYNC QCPPDWTGQY CTEDVDECQL
310 320 330 340 350 360
MPNACQNGGT CHNTYGGYNC VCVNGWTGED CSENIDDCAN AACHSGATCH DRVASFFCEC
370 380 390 400 410 420
PHGRTGLLCH LDNACISNPC NEGSNCDTNP VNGKAICTCP PGYTGPACNN DVDECSLGAN
430 440 450 460 470 480
PCEHGGRCTN TLGSFQCNCP QGYAGPRCEI DVNECLSNPC QNDATCLDQI GEFQCICMPG
490 500 510 520 530 540
YEGLYCETNI DECASNPCLH NGKCVDKINE FHCECPTGFN GNLCQHDVDE CASTPCKNGA
550 560 570 580 590 600
KCLDGPNSYT CQCTEGFTGR HCEQDINECI PDPCHYGTCK DGIATFTCLC RPGYTGRLCD
610 620 630 640 650 660
NDINECLSQP CQNGGQCTDR ENGYICTCPK GTTGVNCETN LDDCASNPCD YGKCIDKIDG
670 680 690 700 710 720
YECTCEPGYT GKMCNINIDE CASNPCRNGG TCKDKINGFT CVCPDGYHDH MCLSEVNECN
730 740 750 760 770 780
SNPCIHGTCH DGINGYKCDC DAGWSGSNCD VNNNECESNP CMNGGTCKDM TGAYICTCRA
790 800 810 820 830 840
GFSGPNCQTN INECASNPCL NRGTCIDDVA GYKCNCMLPY TGAICEAVLA PCSGSPCKNG
850 860 870 880 890 900
GRCKESEDYE TFSCECPPGW QGQTCEIDMN ECVNRPCRNG AMCQNTNGSY KCNCKPGYAG
910 920 930 940 950 960
RHCETDIDDC QPNPCHNGGS CSDGINMFFC NCPAGFRGPK CEEDINECAS NPCKNGANCT
970 980 990 1000 1010 1020
DCVNSYTCTC QPGFSGIHCE NNTPDCTESS CFNGGTCIDG INTFSCQCPP GFTGNYCQHD
1030 1040 1050 1060 1070 1080
INECDSKPCL NGGTCQDSYG AYKCTCPQGY TGLNCQNLVR WCDSSPCKNG GKCWQTNNFY
1090 1100 1110 1120 1130 1140
RCECKSGWTG VYCDVPSVSC EVAAKQQGVD IAHLCRNSGM CVDTGNTHFC RCQAGYTGSY
1150 1160 1170 1180 1190 1200
CEEQVDECSP NPCQNGATCT DYLGGYSCEC VAGYHGVNCS EEINECLSHP CHNGGTCIDL
1210 1220 1230 1240 1250 1260
INTYKCSCPR GTQGVHCEIN VDDCTPFYDS VSLEPKCFNN GKCFDRVGGY NCICPPGFVG
1270 1280 1290 1300 1310 1320
ERCEGDVNEC LSNPCDPRGT QNCIQLVNDY RCECRQGFTG RRCDSVVDGC KGLPCRNGGT
1330 1340 1350 1360 1370 1380
CAVASNTERG FICKCPPGFD GATCEYDART CGNLRCQNGG TCISVLKSSK CVCSEGYTGA
1390 1400 1410 1420 1430 1440
TCQYPVVSPC ASRPCYNGGT CQFSPEEPFF QCFCPTNFNG LFCHILDYGF IGGLGKNITP
1450 1460 1470 1480 1490 1500
PDNEEICENE QCAELADNKI CNANCNNHAC GWDGGDCSLN FNDPWKNCTQ SLQCWKYFND
1510 1520 1530 1540 1550 1560
GKCDSQCNNS GCLYDGFDCQ KVEVQCNPLY DQYCRDHFQD GHCDQGCNNA ECEWDGLDCD
1570 1580 1590 1600 1610 1620
NMPENLAEGT LLIVVLMPPE KLKNNSVNFL RELSRVLHTN VVFKKDSKGE YKIYPYYGNE
1630 1640 1650 1660 1670 1680
EELKKHHIKK RSAASWSDAP TAIFSTMKES VLPGRRRREL DQMEVRGSIV YLEIDNRQCY
1690 1700 1710 1720 1730 1740
KSSSQCFTSA TDVAAFLGAL ATHGNLNIPY KIEAVKSEIV ETAKPPPPLY AMFSMLVIPL
1750 1760 1770 1780 1790 1800
LIIFVIMVVI VNKKRRREHG QLWFPEGFIP KEPSKKKRRE PLGEDSVGLK PLKNLTDGSF
1810 1820 1830 1840 1850 1860
MDDNQNEWGD EETLENKRFR FEEQVMLPEL VDDQTDHRQW TQQHLDAADL RIPSMAPTPP
1870 1880 1890 1900 1910 1920
QGEIDADCMD VNVRGPDGFT PLMIAACSGG GLETGNSEEE EDASANMISD FIGQGAQLHN
1930 1940 1950 1960 1970 1980
QTDRTGETAL HLAARYARAD AAKRLLESSA DANVPDNMGR TPLHAAVAAD AQGVFQILIR
1990 2000 2010 2020 2030 2040
NRATDLDARM CDGTTPLILA ARLAVEGMVE ELINAHADVN AVDEFGKSAL HWAAAVNNVD
2050 2060 2070 2080 2090 2100
AAAVLLKSSA NKDMQNNKEE TPLFLAAREG SYETAKVLLD HYANRDITDH MDRLPRDIAQ
2110 2120 2130 2140 2150 2160
ERMHHDIVHL LDEHNLVKSP TLHGGPLGAP TLSPPICSPN GYMGNMKPSV QSKKARKPSI
2170 2180 2190 2200 2210 2220
KGNGCKEAKE LKARRKKSQD GKTSLLDSGS SGVLSPVDSL ESPHGYLSDV ASPPLMTSPF
2230 2240 2250 2260 2270 2280
QQSPSMPLNH LTSMQDSHLG LNHMTMANKQ EMASNRMAFD GMTPRLTHLN VSSPNTIMTN
2290 2300 2310 2320 2330 2340
GSMHFTVGGA PAMNGQCDWF ARLQNGMVQN QYNPIRNGIQ QGNAQQALQH GLMSSLHNGL
2350 2360 2370 2380 2390 2400
PATTLSQMMT YQAMPNTRMA NQPHLMQAQQ MQQQQNLQLH QSVQQQQHQN SNATSTHIGS
2410 2420 2430 2440 2450 2460
PFCSNDISQT DLQQMSGNNI HSVMPQDTQI FTNSLPPTLT QSMATTQFLT PPSQHSYSSP
2470 2480 2490 2500 2510 2520
MDNTPSHQLQ VPDHPFLTPS PESPDQWSSS SPHSNMSDWS EGISSPPTSM QPQRTHIPEA
FK