A2D649

SS
Gene name
HOXB1
Protein name
Homeobox protein Hox-B1
Names
Species
Macaca mulatta (Rhesus macaque)
KEGG Pathway
mcc:696111
EC number
Protein Class

Descriptions

lab is a member of the Homeotic complex (HOX) family of homeoproteins that are required for specifying cell fates and morphological differences along the anterior-posterior axes of most animals. The lab hexapeptide(also called YPWM motif or pentapeptide) inhibits lab function and activates inappropriate target genes in vivo by inhibiting DNA binding. LAB-EXD interactions functions to remove the inhibitory effect of the hexapeptide and to enhance DNA binding to relevant target sequences by cooperative interactions.

Autoinhibitory domains (AIDs)

176-194 (Hexapeptide) SS

Target domain

204-267 (Homeodomain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2D649

Entry ID Method Resolution Chain Position Source
AF-A2D649-F1 Predicted AlphaFoldDB

No variants for A2D649

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A2D649

No associated diseases with A2D649

4 regional properties for A2D649

Type Name Position InterPro Accession
domain Homeodomain 204 - 268 IPR001356
conserved_site Homeobox, conserved site 239 - 262 IPR017970
domain Homeodomain, metazoa 228 - 239 IPR020479-1
domain Homeodomain, metazoa 243 - 262 IPR020479-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P23459 HOXD8 Homeobox protein Hox-D8 Gallus gallus (Chicken) PR
A2T6Z0 HOXB1 Homeobox protein Hox-B1 Pan troglodytes (Chimpanzee) SS
P10105 lab Homeotic protein labial Drosophila melanogaster (Fruit fly) EV
P31268 HOXA7 Homeobox protein Hox-A7 Homo sapiens (Human) SS
P49639 HOXA1 Homeobox protein Hox-A1 Homo sapiens (Human) SS
P14653 HOXB1 Homeobox protein Hox-B1 Homo sapiens (Human) SS
P09022 Hoxa1 Homeobox protein Hox-A1 Mus musculus (Mouse) SS
O08656 Hoxa1 Homeobox protein Hox-A1 Rattus norvegicus (Rat) SS
P46603 HAT9 Homeobox-leucine zipper protein HAT9 Arabidopsis thaliana (Mouse-ear cress) PR
Q28IU6 hoxd1 Homeobox protein Hox-D1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q8JH55 hoxb8b Homeobox protein Hox-B8b Danio rerio (Zebrafish) (Brachydanio rerio) PR
F1Q4R9 meox1 Homeobox protein MOX-1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MDYNRMNSFL EYPLCNRGPS AYSAHSAHSA PTSFPPSSTQ AVDSYASEGR YGGGLSSPAF
70 80 90 100 110 120
QQNSGYPAQQ PPSALGVPFP SSAPSGYAPA ACSPSYGPSQ YYPLGQSEGD GGYFHPTSYG
130 140 150 160 170 180
AQLGGLSDGY GAGGAGPGPY PPQHPPYGNE QTASFAPAYA DLLSEDKEAP CPSEPNTPTA
190 200 210 220 230 240
RTFDWMKVKR NPPKTGKVSE PGLGSPSGLR TNFTTRQLTE LEKEFHFNKY LSRARRVEIA
250 260 270 280 290 300
ATLELNETQV KIWFQNRRMK QKKREREGGR VPPAPPGCPK EAAGDASDQS TCTSPEASPS
SVTS