A2CG49
SS
Gene name |
Kalrn |
Protein name |
Kalirin |
Names |
EC 2.7.11.1 , Protein Duo , Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:545156 |
EC number |
2.7.11.1: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
TRIO is a guanine nucleotide exchange factor (GEF) that activates the small GTPase RhoA, influencing cell motility and gene transcription. It plays a crucial role in tumor growth in uveal melanoma. The GEF activity of TRIO’s C-terminal module (TrioC) is autoinhibited. The pleckstrin homology (PH) domain interacts with the Dbl homology (DH) domain, blocking the Rho GTPase binding site and preventing activation. Similar to ARHGEF25, Binding of Gαq also relieves the autoinhibition of TRIO. Furthermore, mutations in the DH-PH interface found in cancer patients can disrupt this autoinhibited state, leading to increased RhoA activation and mitogenic signaling, potentially driving cancer progression.
Autoinhibitory domains (AIDs)
Target domain |
1895-2086 (DH domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for A2CG49
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| No available structures | |||||
137 variants for A2CG49
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs224530323 | 2 | V>I | No | EVA | |
| rs3389430951 | 15 | S>P | No | EVA | |
| rs3389430921 | 25 | V>M | No | EVA | |
| rs3389413703 | 27 | F>V | No | EVA | |
| rs3389383180 | 28 | V>L | No | EVA | |
| rs3389394638 | 89 | L>H | No | EVA | |
| rs3389406409 | 141 | L>P | No | EVA | |
| rs1134065777 | 197 | E>G | No | EVA | |
| rs3389374381 | 218 | K>R | No | EVA | |
| rs3389419961 | 253 | S>G | No | EVA | |
| rs3389362459 | 314 | L>* | No | EVA | |
| rs3405944076 | 413 | V>E | No | EVA | |
| rs3406778593 | 413 | V>E | No | EVA | |
| rs3389411520 | 452 | E>* | No | EVA | |
| rs3406751946 | 453 | V>D | No | EVA | |
| rs3406822236 | 454 | S>I | No | EVA | |
| rs3406991733 | 454 | S>I | No | EVA | |
| rs3406764247 | 455 | Q>* | No | EVA | |
| rs3406778628 | 456 | D>E | No | EVA | |
| rs3406242087 | 456 | D>Y | No | EVA | |
| rs3406822238 | 463 | V>D | No | EVA | |
| rs3389406763 | 481 | N>K | No | EVA | |
| rs3389411151 | 482 | Y>D | No | EVA | |
| rs220283686 | 502 | R>Q | No | EVA | |
| rs3389423688 | 511 | K>M | No | EVA | |
| rs3389383148 | 526 | D>V | No | EVA | |
| rs3389430929 | 530 | V>M | No | EVA | |
| rs3389411528 | 560 | K>T | No | EVA | |
| rs3389430914 | 564 | D>V | No | EVA | |
| rs3389394649 | 569 | A>T | No | EVA | |
| rs3389404613 | 570 | Q>E | No | EVA | |
| rs3389374376 | 621 | L>P | No | EVA | |
| rs3389404652 | 632 | T>A | No | EVA | |
| rs3407148322 | 697 | L>P | No | EVA | |
| rs3389374349 | 766 | E>* | No | EVA | |
| rs3389383101 | 871 | C>Y | No | EVA | |
| rs3389329041 | 882 | K>I | No | EVA | |
| rs3389406474 | 1047 | E>* | No | EVA | |
| rs3389394675 | 1055 | R>M | No | EVA | |
| rs3389406425 | 1058 | V>A | No | EVA | |
| rs3389411128 | 1070 | P>T | No | EVA | |
| rs3389419977 | 1071 | E>* | No | EVA | |
| rs3389413769 | 1118 | W>* | No | EVA | |
| rs3389394631 | 1137 | T>R | No | EVA | |
| rs258158272 | 1142 | E>G | No | EVA | |
| rs3389329039 | 1145 | K>* | No | EVA | |
| rs3389329113 | 1214 | N>K | No | EVA | |
| rs3389420008 | 1215 | T>K | No | EVA | |
| rs3406908155 | 1271 | R>W | No | EVA | |
| rs3389394673 | 1300 | H>L | No | EVA | |
| rs3389406403 | 1311 | D>E | No | EVA | |
| rs3389394682 | 1339 | A>E | No | EVA | |
| rs3389383102 | 1341 | K>* | No | EVA | |
| rs3389411463 | 1418 | V>M | No | EVA | |
| rs3389406419 | 1452 | D>E | No | EVA | |
| rs3389413722 | 1468 | E>K | No | EVA | |
| rs3389411060 | 1483 | E>V | No | EVA | |
| rs3389394687 | 1506 | V>A | No | EVA | |
| rs3389374303 | 1521 | S>A | No | EVA | |
| rs3389383126 | 1548 | I>V | No | EVA | |
| rs3389412393 | 1549 | R>L | No | EVA | |
| rs3389374316 | 1555 | R>G | No | EVA | |
| rs3389329035 | 1578 | N>Y | No | EVA | |
| rs3389416551 | 1580 | S>I | No | EVA | |
| rs3389383143 | 1658 | W>L | No | EVA | |
| rs3389411529 | 1659 | C>Y | No | EVA | |
| rs3389412340 | 1685 | R>C | No | EVA | |
| rs230315149 | 1783 | T>M | No | EVA | |
| rs3389423714 | 1811 | L>F | No | EVA | |
| rs3389394659 | 1869 | L>M | No | EVA | |
| rs3389411502 | 1888 | N>K | No | EVA | |
| rs3389411134 | 1893 | Q>H | No | EVA | |
| rs3389383172 | 1897 | A>* | No | EVA | |
| rs3389412378 | 1897 | A>E | No | EVA | |
| rs3389411448 | 1901 | R>K | No | EVA | |
| rs232231899 | 1921 | I>V | No | EVA | |
| rs3389362443 | 1945 | I>F | No | EVA | |
| rs3389362457 | 1950 | I>N | No | EVA | |
| rs3389406404 | 1958 | K>T | No | EVA | |
| rs3389411533 | 1997 | P>S | No | EVA | |
| rs3389380625 | 2029 | K>M | No | EVA | |
| rs212215109 | 2052 | G>D | No | EVA | |
| rs3389362407 | 2062 | V>SDG* | No | EVA | |
| rs3389428912 | 2065 | M>I | No | EVA | |
| rs3389423701 | 2111 | S>T | No | EVA | |
| rs248595958 | 2155 | D>E | No | EVA | |
| rs3389394676 | 2155 | D>Y | No | EVA | |
| rs3389411500 | 2173 | E>* | No | EVA | |
| rs3389362433 | 2196 | L>P | No | EVA | |
| rs3389411130 | 2202 | F>I | No | EVA | |
| rs3389380660 | 2270 | G>W | No | EVA | |
| rs3389419957 | 2298 | T>A | No | EVA | |
| rs3389428891 | 2302 | D>E | No | EVA | |
| rs3389428881 | 2306 | L>Q | No | EVA | |
| rs3389428922 | 2316 | G>D | No | EVA | |
| rs3389428864 | 2319 | V>E | No | EVA | |
| rs3413122990 | 2329 | M>I | No | EVA | |
| rs3389411508 | 2332 | V>A | No | EVA | |
| rs3389428875 | 2346 | W>R | No | EVA | |
| rs3552271816 | 2361 | A>T | No | EVA | |
| rs3406820479 | 2365 | S>R | No | EVA | |
| rs45892376 | 2368 | S>N | No | EVA | |
| rs3389380594 | 2380 | M>* | No | EVA | |
| rs3389380664 | 2382 | K>R | No | EVA | |
| rs3389329084 | 2386 | V>SDG* | No | EVA | |
| rs3389394624 | 2388 | N>K | No | EVA | |
| rs3389406433 | 2389 | S>L | No | EVA | |
| rs3389394633 | 2389 | S>P | No | EVA | |
| rs3389411113 | 2402 | D>* | No | EVA | |
| rs3389428896 | 2402 | D>G* | No | EVA | |
| rs3389380630 | 2442 | A>S | No | EVA | |
| rs3389406465 | 2453 | T>SDG* | No | EVA | |
| rs3389420010 | 2454 | C>R | No | EVA | |
| rs3389412412 | 2487 | D>E | No | EVA | |
| rs3389416503 | 2489 | S>R | No | EVA | |
| rs3411549170 | 2518 | Y>N | No | EVA | |
| rs3389394672 | 2523 | A>S | No | EVA | |
| rs3389380584 | 2531 | T>I | No | EVA | |
| rs3389423664 | 2542 | A>S | No | EVA | |
| rs3389423637 | 2544 | P>R | No | EVA | |
| rs3389406427 | 2587 | W>* | No | EVA | |
| rs3389362487 | 2587 | W>R | No | EVA | |
| rs3389374358 | 2612 | F>L | No | EVA | |
| rs3389406766 | 2618 | N>Y | No | EVA | |
| rs248538395 | 2641 | A>T | No | EVA | |
| rs3389406479 | 2675 | H>D | No | EVA | |
| rs3389416527 | 2676 | K>I | No | EVA | |
| rs3389394683 | 2682 | V>G | No | EVA | |
| rs3405941603 | 2694 | K>T | No | EVA | |
| rs3389420022 | 2713 | V>A | No | EVA | |
| rs3389406731 | 2723 | T>A | No | EVA | |
| rs3389374377 | 2762 | A>D | No | EVA | |
| rs3389406732 | 2812 | L>M | No | EVA | |
| rs3389423678 | 2838 | I>M | No | EVA | |
| rs3406907255 | 2840 | V>D | No | EVA | |
| rs3389411092 | 2938 | N>S | No | EVA | |
| rs3389423731 | 2956 | Q>* | No | EVA |
No associated diseases with A2CG49
26 regional properties for A2CG49
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Dbl homology (DH) domain | 1254 - 1429 | IPR000219-1 |
| domain | Dbl homology (DH) domain | 1900 - 2075 | IPR000219-2 |
| domain | Protein kinase domain | 2656 - 2910 | IPR000719 |
| domain | CRAL-TRIO lipid binding domain | 17 - 163 | IPR001251 |
| domain | SH3 domain | 1619 - 1684 | IPR001452-1 |
| domain | SH3 domain | 2292 - 2357 | IPR001452-2 |
| domain | Pleckstrin homology domain | 1441 - 1555 | IPR001849-1 |
| domain | Pleckstrin homology domain | 2087 - 2199 | IPR001849-2 |
| repeat | Spectrin repeat | 293 - 396 | IPR002017-1 |
| repeat | Spectrin repeat | 522 - 622 | IPR002017-2 |
| repeat | Spectrin repeat | 873 - 971 | IPR002017-3 |
| repeat | Spectrin repeat | 1105 - 1200 | IPR002017-4 |
| domain | Immunoglobulin subtype 2 | 2455 - 2527 | IPR003598 |
| domain | Immunoglobulin subtype | 2449 - 2538 | IPR003599 |
| domain | Fibronectin type III | 2541 - 2637 | IPR003961 |
| domain | Immunoglobulin-like domain | 2443 - 2536 | IPR007110 |
| active_site | Serine/threonine-protein kinase, active site | 2771 - 2783 | IPR008271 |
| domain | Immunoglobulin I-set | 2443 - 2537 | IPR013098 |
| binding_site | Protein kinase, ATP binding site | 2662 - 2685 | IPR017441 |
| repeat | Spectrin/alpha-actinin | 172 - 518 | IPR018159-1 |
| repeat | Spectrin/alpha-actinin | 519 - 748 | IPR018159-2 |
| repeat | Spectrin/alpha-actinin | 765 - 1102 | IPR018159-3 |
| repeat | Spectrin/alpha-actinin | 1106 - 1208 | IPR018159-4 |
| domain | Kalirin/Triple functional domain protein, SH3 domain 1 | 1622 - 1681 | IPR028570 |
| domain | Kalirin/Triple functional domain protein, SH3 domain 2 | 2296 - 2352 | IPR047053 |
| domain | Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1 | 1434 - 1556 | IPR047054 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.1 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extrinsic component of membrane | The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| presynapse | The part of a synapse that is part of the presynaptic cell. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| metal ion binding | Binding to a metal ion. |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
21 GO annotations of biological process
| Name | Definition |
|---|---|
| adult locomotory behavior | Locomotory behavior in a fully developed and mature organism. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| axonogenesis | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. |
| habituation | A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| lactation | The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. |
| maternal behavior | Female behaviors associated with the care and rearing of offspring. |
| maternal process involved in parturition | A reproductive process occurring in the mother that results in birth. |
| memory | The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). |
| modification of postsynaptic actin cytoskeleton | Any process that modifies the structure of a postsynaptic actin cytoskeleton. |
| negative regulation of growth hormone secretion | Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| neuromuscular junction development | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. |
| neurotransmitter receptor localization to postsynaptic specialization membrane | A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density). |
| NMDA selective glutamate receptor signaling pathway | The series of molecular signals initiated by glutamate binding to an NMDA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of dendritic spine morphogenesis | Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. |
| regulation of dendrite development | Any process that modulates the frequency, rate or extent of dendrite development. |
| regulation of modification of postsynaptic actin cytoskeleton | Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton. |
| regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane. |
| social behavior | Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q86YR7 | MCF2L2 | Probable guanine nucleotide exchange factor MCF2L2 | Homo sapiens (Human) | SS |
| O75962 | TRIO | Triple functional domain protein | Homo sapiens (Human) | EV |
| P10911 | MCF2 | Proto-oncogene DBL | Homo sapiens (Human) | EV |
| O15068 | MCF2L | Guanine nucleotide exchange factor DBS | Homo sapiens (Human) | SS |
| O60229 | KALRN | Kalirin | Homo sapiens (Human) | SS |
| Q0KL02 | Trio | Triple functional domain protein | Mus musculus (Mouse) | SS |
| Q9CWR0 | Arhgef25 | Rho guanine nucleotide exchange factor 25 | Mus musculus (Mouse) | SS |
| Q64096 | Mcf2l | Guanine nucleotide exchange factor DBS | Mus musculus (Mouse) | SS |
| F1M0Z1 | Trio | Triple functional domain protein | Rattus norvegicus (Rat) | SS |
| Q63406 | Mcf2l | Guanine nucleotide exchange factor DBS | Rattus norvegicus (Rat) | SS |
| P97924 | Kalrn | Kalirin | Rattus norvegicus (Rat) | SS |
| Q1LUA6 | trio | Triple functional domain protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVLSGSFRND | GLKASDVLPI | LKEKVAFVSG | GRDKRGGPIL | TFPARSNHDR | IRQEDLRKLV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TYLASVPSED | VCKRGFTVII | DMRGSKWDLI | KPLLKTLQEA | FPAEIHVALI | IKPDNFWQKQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KTNFGSSKFI | FETSMVSVEG | LTKLVDPSQL | TEEFDGSLDY | NHEEWIELRL | SLEEFFNSAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HLLSRLEDLQ | EMLARKEFPV | DVEGSRRLID | EHTQLKKKVL | KAPVEELDRE | GQRLLQCIRC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SDGFSGRNCI | PGSADFQSLV | PKITSLLDKL | HSTRQHLHQM | WHVRKLKLDQ | CFQLRLFEQD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AEKMFDWISH | NKELFLQSHT | EIGVSYQHAL | DLQTQHNHFA | MNSMNAYVNI | NRIMSVASRL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SEAGHYASQQ | IKQISTQLDQ | EWKSFAAALD | ERSTILAMSA | VFHQKAEQFL | SGVDAWCKMC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SEGGLPSEMQ | DLELAIHHHQ | SLYEQVTQAY | TEVSQDGKAL | LDVLQRPLSP | GNSESLTATA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NYSKAVHQVL | DVVHEVLHHQ | RRLESIWQHR | KVRLHQRLQL | CVFQQDVQQV | LDWIENHGEA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FLSKHTGVGK | SLHRARALQK | RHDDFEEVAQ | NTYTNADKLL | EAAEQLAQTG | ECDPEEIYKA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ARHLEVRIQD | FVRRVEQRKL | LLDMSVSFHT | HTKELWTWME | DLQKEVLEDV | CADSVDAVQE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LIKQFQQQQT | ATLDATLNVI | KEGEDLIQQL | RSAPPSLGEP | TEARDSAMSN | NKTPHSSSIS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HIESVLQQLD | DAQVQMEELF | HERKIKLDIF | LQLRIFEQYT | IEVTAELDAW | NEDLLRQMND |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FNTEDLTLAE | QRLQRHTERK | LAMNNMTFEV | IQQGQDLHQY | IMEVQASGIE | LICEKDLDLA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| AQVQELLEFL | HEKQHELELN | AEQTHKRLEQ | CLQLRHLQAE | VKQVLGWIRN | GESMLNASLV |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NASSLSEAEQ | LQREHEQFQL | AIEKTHQSAL | QVQQKAEALL | QAGHYDADAI | RECAEKVALH |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| WQQLMLKMED | RLKLVNASVA | FYKTSEQVCS | VLESLEQEYR | RDEDWCGGRD | KLGPAAEMDH |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| VIPLLSKHLE | QKEAFLKACT | LARRNAEVFL | KYIHRNNVSM | PSVASHTRGP | EQQVKAILSE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LLQRENRVLH | FWTLKKRRLD | QCQQYVVFER | SAKQALDWIQ | ETGEYYLSTH | TSTGETTEET |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| QELLKEYGEF | RVPAKQTKEK | VKLLIQLADS | FVEKGHIHAT | EIRKWVTTVD | KHYRDFSLRM |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| GKYRYSLEKA | LGVNTEDNKD | LELDIIPASL | SDREVKLRDA | NHEINEEKRK | SARKKEFIMA |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| ELLQTEKAYV | RDLHECLETY | LWEMTSGVEE | IPPGILNKEH | IIFGNIQEIY | DFHNNIFLKE |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| LEKYEQLPED | VGHCFVTWAD | KFQMYVTYCK | NKPDSNQLIL | EHAGTFFDEI | QQRHGLANSI |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| SSYLIKPVQR | VTKYQLLLKE | LLTCCEEGKG | ELKDGLEVML | SVPKKANDAM | HVSMLEGFDE |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| NLDVQGELIL | QDAFQVWDPK | SLIRKGRERH | LFLFEISLVF | SKEIKDSSGH | TKYVYKNKLL |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| TSELGVTEHV | EGDPCKFALW | SGRTPSSDNK | TVLKASNIET | KQEWIKNIRE | VIQERIIHLK |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| GALKEPIQLP | KTPAKLRNNS | KRDGVEDGDS | QGDGSSQPDT | ISIASRTSQN | TVESDKLSGG |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| CELTVVLQDF | SAGHSSELSI | QVGQTVELLE | RPSERPGWCL | VRTTERSPPQ | EGLVPSSALC |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| ISHSRSSVEM | DCFFPLKDSY | SHSSSENGGK | SESVAHLQSQ | PSLNSIHSSP | GPKRSTNTLK |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| KWLTSPVRRL | NSGKADGNIK | KQKKVRDGRK | SFDLGSPKPG | DETTPQGDSA | DEKSKKGWGE |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| DEPDEESHTP | LPPPMKIFDN | DPTQDEMSSL | LAARQAPPDV | PTAADLVSAI | EKLVKNKLTL |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| EGGSYRGSLK | DPTGCLNEGM | TPPTPPRNLE | EEQKAKALRG | RMFVLNELVQ | TEKDYVKDLG |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| IVVEGFMKRI | EEKGVPEDMR | GKEKIVFGNI | HQIYDWHKDF | FLAELEKCIQ | EQDRLAQLFI |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| KHERKLHIYV | WYCQNKPRSE | YIVAEYDAYF | EEVKQEINQR | LTLSDFLIKP | IQRITKYQLL |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| LKDFLRYSEK | AGLECSDIEK | AVELMCLVPK | RCNDMMNLGR | LQGFEGTLTA | QGKLLQQDTF |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| YVIELDAGMQ | SRTKERRVFL | FEQIVIFSEL | LRKGSLTPGY | MFKRSIKMNY | LVLEDNVDGD |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| PCKFALMNRE | TSERVILQAA | NSDIQQAWVQ | DINQVLETQR | DFLNALQSPI | EYQRKERSTA |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| VIRSQPPRVP | QASPRPYSSG | PVGSEKPPKG | SSYNPPLPPL | KISTSNGSPG | FDYHQPGDKF |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| DASKQNDLGG | CNGTSTMTVI | KDYYALKENE | ICVSQGEVVQ | VLAVNQQNMC | LVYQPASDHS |
| 2350 | 2360 | 2370 | 2380 | 2390 | 2400 |
| PAAEGWVPGS | ILAPLAKATA | AAESSDGSIK | KSCSWHTLRM | RKRADVENSG | KNEATGPRKP |
| 2410 | 2420 | 2430 | 2440 | 2450 | 2460 |
| KDILGNKVSV | KETNSSEESE | CDDLDPNTSM | EILNPNFIQE | VAPEFLVPLV | DVTCLLGDTV |
| 2470 | 2480 | 2490 | 2500 | 2510 | 2520 |
| LLQCKACGRP | KPSITWKGPD | QNILDTDNSS | ATYTISSCDS | GESTLKICNL | MPQDSGIYTC |
| 2530 | 2540 | 2550 | 2560 | 2570 | 2580 |
| IAANDHGTAS | TSATVKVQGV | PAAPNRPIAQ | ERSCTSVILR | WLPPASTGNC | TISGYTVEYR |
| 2590 | 2600 | 2610 | 2620 | 2630 | 2640 |
| EEGSQVWQQS | VASTLDTYLV | IEDLSPGCPY | QFRVSASNPW | GISLPSEPSE | FVRLPEYDAA |
| 2650 | 2660 | 2670 | 2680 | 2690 | 2700 |
| ADGATISWKE | NFDSAYTELN | EIGRGRFSIV | KKCIHKATRK | DVAVKFVSKK | MKKKEQAAHE |
| 2710 | 2720 | 2730 | 2740 | 2750 | 2760 |
| AALLQHLQHP | QYVTLHDTYE | SPTSYILILE | LMDDGRLLDY | LMNHDELMEE | KVAFYIRDIM |
| 2770 | 2780 | 2790 | 2800 | 2810 | 2820 |
| EALQYLHNCR | VAHLDIKPEN | LLIDLRIPVP | RVKLIDLEDA | VQISGHFHIH | HLLGNPEFAA |
| 2830 | 2840 | 2850 | 2860 | 2870 | 2880 |
| PEVIQGIPVS | LGTDIWSIGV | LTYVMLSGVS | PFLDESKEET | CINVCRVDFS | FPHEYFCGVS |
| 2890 | 2900 | 2910 | 2920 | 2930 | 2940 |
| NAARDFINVI | LQEDFRRRPT | AATCLQHPWL | QPHNGSYSKI | PLDTSRLACF | IERRKHQNDV |
| 2950 | 2960 | ||||
| RPIPNVKSYI | VNRVNQGTSL | SHNP |