A2AR50

PR
Gene name
Ralgps1 (Kiaa0351, Ralgef2, Ralgps1a)
Protein name
Ras-specific guanine nucleotide-releasing factor RalGPS1
Names
Ral GEF with PH domain and SH3-binding motif 1, Ral guanine nucleotide exchange factor 2, RalGEF 2, RalA exchange factor RalGPS1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:241308
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for A2AR50

Entry ID Method Resolution Chain Position Source
2DTC X-ray 170 A A/B 460-585 PDB
AF-A2AR50-F1 Predicted AlphaFoldDB

34 variants for A2AR50

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3391385959 25 D>G No EVA
rs3391437624 29 G>C No EVA
rs3391490397 30 Q>L No EVA
rs3388538725 53 E>D No EVA
rs245378251 111 T>K No EVA
rs864262544 114 T>I No EVA
rs3388551059 115 L>* No EVA
rs3388549592 164 N>T No EVA
rs3388546307 172 E>D No EVA
rs3388547758 185 K>R No EVA
rs3391436171 193 S>R No EVA
rs3391416733 194 L>Q No EVA
rs3388538747 202 Y>* No EVA
rs3391355965 217 Y>* No EVA
rs3391460669 218 P>A No EVA
rs864285892 220 S>T No EVA
rs3391309920 258 V>AG* No EVA
rs3388550207 266 R>C No EVA
rs3388546959 291 S>C No EVA
rs3388549298 291 S>I No EVA
rs3388549310 329 L>I No EVA
rs27209559 377 S>F No EVA
rs3391173816 381 R>C No EVA
rs3391448577 382 R>G No EVA
rs3388543822 393 T>N No EVA
rs3388546843 431 P>Q No EVA
rs3388546427 452 T>I No EVA
rs3388545931 459 V>E No EVA
rs3388546364 487 W>R No EVA
rs3388549224 498 Y>H No EVA
rs235587540 506 T>S No EVA
rs3388545235 513 S>T No EVA
rs3410683747 525 M>T No EVA
rs3388538686 531 D>E No EVA

No associated diseases with A2AR50

3 regional properties for A2AR50

Type Name Position InterPro Accession
domain Protein kinase domain 25 - 316 IPR000719
conserved_site Mitogen-activated protein (MAP) kinase, conserved site 60 - 163 IPR003527
binding_site Protein kinase, ATP binding site 31 - 55 IPR017441

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane
  • Associates with membranes through the PH domain
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

3 GO annotations of biological process

Name Definition
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
Ras protein signal transduction The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
regulation of Ral protein signal transduction Any process that modulates the frequency, rate or extent of Ral protein signal transduction.

28 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6N9I4 RASGRP2 RAS guanyl-releasing protein 2 Bos taurus (Bovine) SS
Q1LZ97 RASGRP4 RAS guanyl-releasing protein 4 Bos taurus (Bovine) SS
A0A3S5ZPR1 RASGRP3 RAS guanyl releasing protein 3 Gallus gallus (Chicken) SS
P26675 Sos Protein son of sevenless Drosophila melanogaster (Fruit fly) SS
Q07890 SOS2 Son of sevenless homolog 2 Homo sapiens (Human) SS
O95267 RASGRP1 RAS guanyl-releasing protein 1 Homo sapiens (Human) EV
Q7LDG7 RASGRP2 RAS guanyl-releasing protein 2 Homo sapiens (Human) EV SS
Q13905 RAPGEF1 Rap guanine nucleotide exchange factor 1 Homo sapiens (Human) PR
Q8IV61 RASGRP3 Ras guanyl-releasing protein 3 Homo sapiens (Human) SS
Q07889 SOS1 Son of sevenless homolog 1 Homo sapiens (Human) EV
Q8TDF6 RASGRP4 RAS guanyl-releasing protein 4 Homo sapiens (Human) SS
Q86X27 RALGPS2 Ras-specific guanine nucleotide-releasing factor RalGPS2 Homo sapiens (Human) PR
Q5JS13 RALGPS1 Ras-specific guanine nucleotide-releasing factor RalGPS1 Homo sapiens (Human) PR
Q02384 Sos2 Son of sevenless homolog 2 Mus musculus (Mouse) SS
Q62245 Sos1 Son of sevenless homolog 1 Mus musculus (Mouse) SS
Q8VCC8 Rapgef3 Rap guanine nucleotide exchange factor 3 Mus musculus (Mouse) SS
Q9EQZ6 Rapgef4 Rap guanine nucleotide exchange factor 4 Mus musculus (Mouse) EV
Q9D300 Rasgef1c Ras-GEF domain-containing family member 1C Mus musculus (Mouse) PR
Q03385 Ralgds Ral guanine nucleotide dissociation stimulator Mus musculus (Mouse) PR
Q9Z1S3 Rasgrp1 RAS guanyl-releasing protein 1 Mus musculus (Mouse) SS
Q8BTM9 Rasgrp4 RAS guanyl-releasing protein 4 Mus musculus (Mouse) SS
Q9QUG9 Rasgrp2 RAS guanyl-releasing protein 2 Mus musculus (Mouse) SS
Q9ERD6 Ralgps2 Ras-specific guanine nucleotide-releasing factor RalGPS2 Mus musculus (Mouse) PR
Q9R1K8 Rasgrp1 RAS guanyl-releasing protein 1 Rattus norvegicus (Rat) SS
P0C643 Rasgrp2 RAS guanyl-releasing protein 2 Rattus norvegicus (Rat) SS
Q8R5I4 Rasgrp4 RAS guanyl-releasing protein 4 Rattus norvegicus (Rat) SS
Q9N5D3 sos-1 Son of sevenless homolog Caenorhabditis elegans EV
A4IJ06 rasgrp1 RAS guanyl-releasing protein 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
10 20 30 40 50 60
MYKRNGLMAS VLVTSATPQG SSSSDSLEGQ SCDYASKSYD AVVFDVLKVT PEEFASQITL
70 80 90 100 110 120
MDIPVFKAIQ PEELASCGWS KKEKHSLAPN VVAFTRRFNQ VSFWVVREIL TAQTLKIRAE
130 140 150 160 170 180
ILSHFVKIAK KLLELNNLHS LMSVVSALQS APIFRLTKTW ALLNRKDKTT FEKLDYLMSK
190 200 210 220 230 240
EDNYKRTRDY IRSLKMVPSI PYLGIYLLDL IYIDSAYPAS GSIMENEQRS NQMNNILRII
250 260 270 280 290 300
ADLQVSCSYD HLTTLPHVQK YLKSVRYIEE LQKFVEDDNY KLSLRIEPGS SSPRLVSSKE
310 320 330 340 350 360
DLAGPSAGSS SARFRRRPTC PDTSVAGSLP TPPVPRHRKS HSLGNNLMCQ LSVVESKSAT
370 380 390 400 410 420
FPSEKARHLL DDSVLESRSP RRGLTHTSST AITNGLSLGS SESSEFSEEM SAGLESRGRL
430 440 450 460 470 480
YATLGPNWRV PVRNSPRTRS CVYSPTSPCT CTVGSSATVP TMEGPLRRKT LLKEGRKPAL
490 500 510 520 530 540
SSWTRYWVVL SGATLLYYGA KSLRGTDRKH YKSTPGKKVS IVGWMVQLPD DPEHPDIFQL
550 560 570 580
NNPDKGNVYK FQTGSRFHAI LWHKHLDDAC KSSRPQVPAN LMSFE