A2AQW0
Gene name |
Map3k15 |
Protein name |
Mitogen-activated protein kinase kinase kinase 15 |
Names |
MAPK/ERK kinase kinase 15, MEK kinase 15, MEKK 15 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:270672 |
EC number |
2.7.11.25: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
(Annotation based on sequence homology with Q99683)
Apoptosis signal-regulating kinases (ASK1-3) are MAP3Ks that trigger cellular responses to redox stress and inflammatory cytokines and play vital roles in innate immunity and viral infection. When activated, ASK1?3 activates JNK and p38 via phosphorylation of MAP2Ks (MKK3/4/6/7). ASK1?3 shares a conserved architecture in which the central kinase domain is flanked on either side by additional domains, and multimeric association appears to be crucial to the activity of these domains. Regulatory factors, such as thioredoxin, associate with the N-terminal thioredoxin-binding domain to negatively regulate activity. Activity can be induced by oxidation, thioredoxin dissociation, or TRAF association (among other stimuli), at which point the activating pleckstrin homology surface becomes available for MAP2K association, activation loop priming, and phosphorylation.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
795-818 (Activation loop from InterPro)
Target domain |
656-912 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for A2AQW0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2AQW0-F1 | Predicted | AlphaFoldDB |
64 variants for A2AQW0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3411196507 | 25 | P>T | No | EVA | |
| rs3409783123 | 35 | E>V | No | EVA | |
| rs581211111 | 60 | P>T | No | EVA | |
| rs264956693 | 77 | A>V | No | EVA | |
| rs3409783105 | 107 | F>L | No | EVA | |
| rs3412858688 | 107 | F>V | No | EVA | |
| rs3411691868 | 107 | F>Y | No | EVA | |
| rs3389539139 | 147 | R>Q | No | EVA | |
| rs3389588662 | 167 | A>T | No | EVA | |
| rs3389489251 | 169 | S>* | No | EVA | |
| rs3412396645 | 202 | E>V | No | EVA | |
| rs3389579651 | 231 | R>S | No | EVA | |
| rs3412859785 | 332 | F>I | No | EVA | |
| rs3412488735 | 332 | F>Y | No | EVA | |
| rs3412941538 | 334 | L>V | No | EVA | |
| rs3389592947 | 373 | K>Q | No | EVA | |
| rs3389539135 | 386 | S>C | No | EVA | |
| rs3412079380 | 391 | I>S | No | EVA | |
| rs3412079424 | 441 | K>N | No | EVA | |
| rs3389579677 | 443 | S>I | No | EVA | |
| rs3389539101 | 451 | W>R | No | EVA | |
| rs3389577427 | 454 | G>C | No | EVA | |
| rs29306677 | 459 | V>I | No | EVA | |
| rs3389539073 | 460 | S>N | No | EVA | |
| rs3389575512 | 491 | Q>* | No | EVA | |
| rs3411093370 | 513 | L>P | No | EVA | |
| rs3389575496 | 519 | I>N | No | EVA | |
| rs3389590502 | 529 | N>K | No | EVA | |
| rs3389574076 | 534 | P>L | No | EVA | |
| rs3389532538 | 575 | E>D | No | EVA | |
| rs3412079360 | 582 | S>Y | No | EVA | |
| rs3389581789 | 634 | S>G | No | EVA | |
| rs3412398924 | 649 | Y>V | No | EVA | |
| rs1131739816 | 652 | D>H | No | EVA | |
| rs3412601556 | 658 | E>A | No | EVA | |
| rs3389574110 | 720 | V>I | No | EVA | |
| rs3411198836 | 742 | L>F | No | EVA | |
| rs3389581809 | 744 | S>T | No | EVA | |
| rs3411695190 | 745 | K>* | No | EVA | |
| rs3389581792 | 745 | K>N | No | EVA | |
| rs3412601691 | 748 | P>S | No | EVA | |
| rs3389581721 | 769 | H>N | No | EVA | |
| rs3389581332 | 785 | V>L | No | EVA | |
| rs3412602318 | 840 | S>P | No | EVA | |
| rs3389574065 | 844 | T>I | No | EVA | |
| rs3411200963 | 849 | A>T | No | EVA | |
| rs3412079428 | 879 | E>V | No | EVA | |
| rs3389548630 | 892 | C>S | No | EVA | |
| rs3389539074 | 900 | R>S | No | EVA | |
| rs3389539156 | 947 | V>M | No | EVA | |
| rs3389574092 | 963 | A>T | No | EVA | |
| rs3389548634 | 967 | A>V | No | EVA | |
| rs3412686165 | 970 | E>V | No | EVA | |
| rs3389489241 | 1040 | V>E | No | EVA | |
| rs3389559981 | 1063 | D>N | No | EVA | |
| rs3389532560 | 1128 | R>G | No | EVA | |
| rs3389548638 | 1163 | D>G | No | EVA | |
| rs260487656 | 1191 | G>S | No | EVA | |
| rs3412400537 | 1204 | K>* | No | EVA | |
| rs3412433175 | 1204 | K>M | No | EVA | |
| rs3389548580 | 1213 | W>R | No | EVA | |
| rs3389590491 | 1263 | D>V | No | EVA | |
| rs3389588733 | 1295 | N>I | No | EVA | |
| rs1132853008 | 1297 | I>F | No | EVA |
No associated diseases with A2AQW0
3 regional properties for A2AQW0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | 14-3-3 protein, conserved site | 45 - 55 | IPR023409-1 |
| conserved_site | 14-3-3 protein, conserved site | 217 - 236 | IPR023409-2 |
| domain | 14-3-3 domain | 7 - 248 | IPR023410 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.25 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| MAP kinase kinase kinase activity | Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. |
| metal ion binding | Binding to a metal ion. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein serine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O95382 | MAP3K6 | Mitogen-activated protein kinase kinase kinase 6 | Homo sapiens (Human) | SS |
| Q99683 | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 | Homo sapiens (Human) | EV |
| Q6ZN16 | MAP3K15 | Mitogen-activated protein kinase kinase kinase 15 | Homo sapiens (Human) | SS |
| O35099 | Map3k5 | Mitogen-activated protein kinase kinase kinase 5 | Mus musculus (Mouse) | SS |
| Q9WTR2 | Map3k6 | Mitogen-activated protein kinase kinase kinase 6 | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGGGGSGGG | GGPVPAEAPE | EAGEPPQGRL | PPGPEGAAGL | AEPESTGDAA | GGEAEGGRGP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RRALRAVYVR | SESSQGAAAG | GGPEAGALKC | LLRACEAEGA | HLTSVPFGEL | DFGETAVLDA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FYDADVAIVD | MSDISRQPSL | FYHLGVRESF | DMANNVILYY | DTDADTALSL | KDMVTQKNTA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSGNYYFIPY | TVTPCADYFC | CESDAQRRAS | EYMQPNWDTI | LGPLCMPLVD | RFTSLLKDIR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VTSCAYYKET | LLNDIRKARE | KYQGDELAKE | LTRIKFRMDN | IEVLTSDIII | NLLLSYRDIQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DYDAMVKLVE | TLKMLPTCDL | ADQHNIKFHY | AFALNRRNST | GDREKALQVM | LQVLQSCDHP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| APDMFCLCGR | IYKDIFLDSG | CEEDASRDSA | IEWYRKGFEL | QSSLYSGINL | AVLLIVSGQQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FETSMELRKI | GVRLNSLLGR | KGSLEKMNNY | WDVGQFFTVS | MLASDIGKAV | QAAERLFKLK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PPVWYLRSLV | QNLLLIQRFK | KPITEHSPRQ | ERLNFWLDII | FEATNEVTNG | LRFPVLVIEP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TKVYQPSYVS | INNEAEERTV | SLWHVSPTEM | KQIHEWNFTA | SSIKGISLSK | FDERCCFLYV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HDNSDDFQIY | FSTEDQCNRF | CSLVKEMLNN | GVGSTVELEG | EADGDTLEYE | YDHDANGERV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VLGKGSYGIV | YAGRDLSNQV | RIAIKEIPER | DIRYSQPLHE | EIALHKYLKH | RNIVQYLGSV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SENGYIKIFM | EQVPGGSLSA | LLRSKWGPMK | EPTIKFYTKQ | ILEGLKYLHE | NQIVHRDIKG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DNVLVNTYSG | VVKISDFGTS | KRLAGINPCT | ETFTGTLQYM | APEIIDQGPR | GYGAPADIWS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LGCTIIEMAT | SRPPFHELGE | PQAAMFKVGM | FKIHPEIPEA | LSAEARAFIL | SCFEPDPQKR |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VTAADLLQEG | FLRQVNKGKK | NRIAFKPSEG | VRSGTGTLAL | PSSGELVGSS | SSEHGSISPD |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SDAQPDAFFE | KVQVPKHQLS | HLLSVPDESP | ALDDRSTALP | PEERDPGLFL | LRKDSERRAI |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LYRILWEEQN | QVASNLQECV | VQSSEELLLS | VSHIKQIIGI | LRDFIRSPEH | RVMAATISKL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| KVDLDFDSSS | INQIHLILFG | FQDAVNRILR | NHLIRPHWMF | AMDNIIRRAV | QAAVTILIPE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LQAHFEPASE | TEGVDKDTEV | EGDYPLVDLL | SQEVHVTPRG | TRPGSVAIQE | GQPHQQDPSL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| QLSKLRQETN | RLWEHLVQKE | REYQNLLRLI | LDQKTQELYH | LQLQYKSNGG | TENPPPPDGL |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| GTDRELIDWL | QLQGVDANTI | EKIVEEDYTL | SDILNDITKE | DLRCLRLRGG | VLCRLWHAVS |
| 1330 | |||||
| QHRRQMQESS | Q |