A2APV2

SS
Gene name
Fmnl2 (Kiaa1902, Man)
Protein name
Formin-like protein 2
Names
Protein Man
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:71409
EC number
Protein Class

Descriptions

(Annotation from UniProt)
The DAD domain may regulate activation via by an autoinhibitory interaction with the N-terminus. This autoinhibition may be released upon competitive binding of an activated GTPase. The release of DAD may allow the FH2 domain to nucleate and elongate nonbranched actin filaments.

Autoinhibitory domains (AIDs)

1038-1077 (DAD domain) SS

Target domain

23-469 (GBD/FH3 domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2APV2

Entry ID Method Resolution Chain Position Source
AF-A2APV2-F1 Predicted AlphaFoldDB

4 variants for A2APV2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs13476502 158 M>V No Ensembl
rs241895132 547 T>I No Ensembl
rs1133603072 805 I>V No Ensembl
rs227442452 1080 V>M No Ensembl

No associated diseases with A2APV2

106 regional properties for A2APV2

Type Name Position InterPro Accession
domain Protein kinase domain 15934 - 16189 IPR000719
domain Immunoglobulin subtype 2 102 - 167 IPR003598-1
domain Immunoglobulin subtype 2 833 - 904 IPR003598-2
domain Immunoglobulin subtype 2 957 - 1025 IPR003598-3
domain Immunoglobulin subtype 2 1147 - 1214 IPR003598-4
domain Immunoglobulin subtype 2 1691 - 1758 IPR003598-5
domain Immunoglobulin subtype 2 3192 - 3261 IPR003598-6
domain Immunoglobulin subtype 2 3910 - 3976 IPR003598-7
domain Immunoglobulin subtype 2 4245 - 4311 IPR003598-8
domain Immunoglobulin subtype 2 12296 - 12367 IPR003598-9
domain Immunoglobulin subtype 2 12452 - 12523 IPR003598-10
domain Immunoglobulin subtype 2 13977 - 14044 IPR003598-11
domain Immunoglobulin subtype 2 14463 - 14531 IPR003598-12
domain Immunoglobulin subtype 2 14559 - 14625 IPR003598-13
domain Immunoglobulin subtype 2 14651 - 14718 IPR003598-14
domain Immunoglobulin subtype 2 15208 - 15266 IPR003598-15
domain Immunoglobulin subtype 2 15295 - 15362 IPR003598-16
domain Immunoglobulin subtype 2 15611 - 15678 IPR003598-17
domain Immunoglobulin subtype 2 15707 - 15775 IPR003598-18
domain Immunoglobulin subtype 2 16280 - 16349 IPR003598-19
domain Immunoglobulin subtype 2 16410 - 16478 IPR003598-20
domain Immunoglobulin subtype 2 16509 - 16578 IPR003598-21
domain Immunoglobulin subtype 2 16618 - 16684 IPR003598-22
domain Immunoglobulin subtype 2 16717 - 16785 IPR003598-23
domain Immunoglobulin subtype 2 16842 - 16909 IPR003598-24
domain Immunoglobulin subtype 2 16945 - 17014 IPR003598-25
domain Immunoglobulin subtype 2 17050 - 17117 IPR003598-26
domain Immunoglobulin subtype 2 17262 - 17327 IPR003598-27
domain Immunoglobulin subtype 2 17370 - 17438 IPR003598-28
domain Immunoglobulin subtype 2 17469 - 17537 IPR003598-29
domain Immunoglobulin subtype 2 17583 - 17652 IPR003598-30
domain Immunoglobulin subtype 2 17688 - 17761 IPR003598-31
domain Immunoglobulin subtype 2 17794 - 17862 IPR003598-32
domain Immunoglobulin subtype 2 18021 - 18088 IPR003598-33
domain Immunoglobulin subtype 2 18134 - 18202 IPR003598-34
domain Immunoglobulin subtype 2 18239 - 18307 IPR003598-35
domain Immunoglobulin subtype 2 18341 - 18408 IPR003598-36
domain Immunoglobulin subtype 2 18441 - 18509 IPR003598-37
domain Immunoglobulin subtype 96 - 178 IPR003599-1
domain Immunoglobulin subtype 211 - 294 IPR003599-2
domain Immunoglobulin subtype 413 - 495 IPR003599-3
domain Immunoglobulin subtype 713 - 802 IPR003599-4
domain Immunoglobulin subtype 827 - 915 IPR003599-5
domain Immunoglobulin subtype 955 - 1038 IPR003599-6
domain Immunoglobulin subtype 1141 - 1225 IPR003599-7
domain Immunoglobulin subtype 1685 - 1769 IPR003599-8
domain Immunoglobulin subtype 2911 - 2995 IPR003599-9
domain Immunoglobulin subtype 3009 - 3089 IPR003599-10
domain Immunoglobulin subtype 3111 - 3269 IPR003599-11
domain Immunoglobulin subtype 3795 - 3880 IPR003599-12
domain Immunoglobulin subtype 3904 - 3987 IPR003599-13
domain Immunoglobulin subtype 4239 - 4318 IPR003599-14
domain Immunoglobulin subtype 8772 - 8945 IPR003599-15
domain Immunoglobulin subtype 10279 - 10364 IPR003599-16
domain Immunoglobulin subtype 10373 - 10468 IPR003599-17
domain Immunoglobulin subtype 12180 - 12268 IPR003599-18
domain Immunoglobulin subtype 12290 - 12378 IPR003599-19
domain Immunoglobulin subtype 12446 - 12534 IPR003599-20
domain Immunoglobulin subtype 13880 - 13960 IPR003599-21
domain Immunoglobulin subtype 13971 - 14052 IPR003599-22
domain Immunoglobulin subtype 14064 - 14148 IPR003599-23
domain Immunoglobulin subtype 14457 - 14542 IPR003599-24
domain Immunoglobulin subtype 14553 - 14634 IPR003599-25
domain Immunoglobulin subtype 14644 - 14727 IPR003599-26
domain Immunoglobulin subtype 14739 - 14821 IPR003599-27
domain Immunoglobulin subtype 15196 - 15278 IPR003599-28
domain Immunoglobulin subtype 15289 - 15373 IPR003599-29
domain Immunoglobulin subtype 15605 - 15689 IPR003599-30
domain Immunoglobulin subtype 15701 - 15788 IPR003599-31
domain Immunoglobulin subtype 16274 - 16360 IPR003599-32
domain Immunoglobulin subtype 16404 - 16489 IPR003599-33
domain Immunoglobulin subtype 16503 - 16589 IPR003599-34
domain Immunoglobulin subtype 16612 - 16695 IPR003599-35
domain Immunoglobulin subtype 16711 - 16796 IPR003599-36
domain Immunoglobulin subtype 16836 - 16920 IPR003599-37
domain Immunoglobulin subtype 16939 - 17025 IPR003599-38
domain Immunoglobulin subtype 17044 - 17128 IPR003599-39
domain Immunoglobulin subtype 17256 - 17338 IPR003599-40
domain Immunoglobulin subtype 17364 - 17449 IPR003599-41
domain Immunoglobulin subtype 17463 - 17548 IPR003599-42
domain Immunoglobulin subtype 17577 - 17663 IPR003599-43
domain Immunoglobulin subtype 17682 - 17772 IPR003599-44
domain Immunoglobulin subtype 17788 - 17873 IPR003599-45
domain Immunoglobulin subtype 18015 - 18099 IPR003599-46
domain Immunoglobulin subtype 18128 - 18213 IPR003599-47
domain Immunoglobulin subtype 18233 - 18318 IPR003599-48
domain Immunoglobulin subtype 18335 - 18419 IPR003599-49
domain Immunoglobulin subtype 18435 - 18520 IPR003599-50
domain Fibronectin type III 8948 - 9041 IPR003961-1
domain Fibronectin type III 10459 - 10553 IPR003961-2
domain Fibronectin type III 14151 - 14247 IPR003961-3
domain Fibronectin type III 14251 - 14348 IPR003961-4
domain Fibronectin type III 14350 - 14448 IPR003961-5
domain Fibronectin type III 14824 - 14920 IPR003961-6
domain Fibronectin type III 14937 - 15027 IPR003961-7
domain Fibronectin type III 15380 - 15475 IPR003961-8
domain Fibronectin type III 15501 - 15596 IPR003961-9
domain Fibronectin type III 15602 - 15680 IPR003961-10
domain Fibronectin type III 15789 - 15883 IPR003961-11
domain Fibronectin type III 17152 - 17245 IPR003961-12
active_site Serine/threonine-protein kinase, active site 16051 - 16063 IPR008271
domain Immunoglobulin V-set domain 14563 - 14620 IPR013106-1
domain Immunoglobulin V-set domain 16721 - 16780 IPR013106-2
domain Immunoglobulin V-set domain 17374 - 17433 IPR013106-3
domain Immunoglobulin V-set domain 17473 - 17532 IPR013106-4
binding_site Protein kinase, ATP binding site 15940 - 15963 IPR017441

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
small GTPase binding Binding to a small monomeric GTPase.

5 GO annotations of biological process

Name Definition
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
regulation of cell morphogenesis Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.
regulation of cell shape Any process that modulates the surface configuration of a cell.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VUC6 Frl Formin-like protein Drosophila melanogaster (Fruit fly) EV
O95466 FMNL1 Formin-like protein 1 Homo sapiens (Human) SS
Q8IVF7 FMNL3 Formin-like protein 3 Homo sapiens (Human) SS
Q96PY5 FMNL2 Formin-like protein 2 Homo sapiens (Human) SS
Q6ZPF4 Fmnl3 Formin-like protein 3 Mus musculus (Mouse) SS
Q9JL26 Fmnl1 Formin-like protein 1 Mus musculus (Mouse) SS
10 20 30 40 50 60
MGNAGSMDSQ QTDFKAHNVP LKLPMPEPGE LEERFAIVLN AMNLPPDKAR LLRQYDNEKK
70 80 90 100 110 120
WELICDQERF QVKNPPHTYI QKLKGYLDPA VTRKKFRRRV QESTQVLREL EISLRTNHIG
130 140 150 160 170 180
WVREFLNEEN KGLDVLVEYL SFAQYAVTFD FESVESTMES TVDKSKPWSR SIEDLHRGSN
190 200 210 220 230 240
LPSPVGNSVS RSGRHSALRY NTLPSRRTLK NSRLVSKKDD VHVCIMCLRA IMNYQYGFNM
250 260 270 280 290 300
VMSHPHAVNE IALSLNNKNP RTKALVLELL AAVCLVRGGH EIILSAFDNF KEVCGEKQRF
310 320 330 340 350 360
EKLMEHFRNE DNNIDFMVAS MQFINIVVHS VEDMNFRVHL QYEFTKLGLD EYLDKLKHTE
370 380 390 400 410 420
SDKLQVQIQA YLDNVFDVGA LLEDAETKNA ALERVEELEE NISHLSEKLQ DTENEAMSKI
430 440 450 460 470 480
VELEKQLMQR NKELDVVREI YKDANTQVHT LRKMVKEKEE AIQRQSTLEK KIHELEKQGT
490 500 510 520 530 540
IKIQKKGDGD IAILPVMASG TLSTGSELAV GNYVGSVPGA TTSGPSVPPP PPLPPSSDTS
550 560 570 580 590 600
EAAQNGTASP PMSPPPPPPP PPPPPPPPPP PLPGPAAETS PAPPLPPPPP PSAPPLPGTS
610 620 630 640 650 660
SPTVVFNSGL AAVKIKKPIK TKFRMPVFNW VALKPNQING TVFNEIDDER ILEDLNVDEF
670 680 690 700 710 720
EEIFKTKAQG PAIDLSSSKQ KITQKASSKV TLLEANRAKN LAITLRKAGK SADEICKAIH
730 740 750 760 770 780
VFDLKTLPVD FVECLMRFLP TENEVKVLRL YERERKPLEN LSDEDRFMMQ FSKIERLLQK
790 800 810 820 830 840
MTIMAFIGNF TESIQMLTPQ LHAIIAASVS IKSSQKLKKI LEIILALGNY MNSSKRGAVY
850 860 870 880 890 900
GFKLQSLDLL LDTKSTDRKQ TLLHYISNVV KEKYQQVTLF YNELHYVEKA AAVSLENVLL
910 920 930 940 950 960
DVKELQRGMD LTKREYTMHD HNTLLKEFLL HNEGKLKKLQ EDAKIAQDAF DDVVKYFGEN
970 980 990 1000 1010 1020
PKTTPPSVFF PVFVRFVKAY KQAEEENELR KKQEQALMEK LLEQEALMEQ QDAKSPSHKS
1030 1040 1050 1060 1070 1080
KRQQQELIAE LRRRQVKDNR HVYEGKDGAI EDIITALKKN NITKFPNVHS RVRISSSTPV
VEDTQS