A2AD83
PR
Gene name |
Frmd7 |
Protein name |
FERM domain-containing protein 7 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:385354 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2AD83
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2AD83-F1 | Predicted | AlphaFoldDB |
64 variants for A2AD83
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389515548 | 25 | K>Q | No | EVA | |
| rs3389558768 | 35 | L>F | No | EVA | |
| rs3410427359 | 39 | E>F* | No | EVA | |
| rs3389553407 | 52 | G>R | No | EVA | |
| rs3389571558 | 54 | N>I | No | EVA | |
| rs30271295 | 55 | V>D | No | EVA | |
| rs3410543745 | 69 | N>I | No | EVA | |
| rs253047151 | 73 | V>I | No | EVA | |
| rs3389526585 | 102 | I>K | No | EVA | |
| rs3389508329 | 112 | P>L | No | EVA | |
| rs3409794722 | 115 | D>V | No | EVA | |
| rs3389560266 | 119 | A>V | No | EVA | |
| rs3410221374 | 144 | Q>* | No | EVA | |
| rs3409400958 | 188 | G>R | No | EVA | |
| rs3389571508 | 205 | A>G | No | EVA | |
| rs3410543744 | 219 | K>E | No | EVA | |
| rs3389467189 | 225 | W>* | No | EVA | |
| rs3389538900 | 231 | L>V | No | EVA | |
| rs3389538912 | 233 | F>L | No | EVA | |
| rs3389568848 | 262 | D>G | No | EVA | |
| rs3410543790 | 266 | A>S | No | EVA | |
| rs3408942776 | 267 | F>S | No | EVA | |
| rs3409794346 | 268 | W>* | No | EVA | |
| rs3409794379 | 268 | W>R | No | EVA | |
| rs3409399144 | 270 | T>P | No | EVA | |
| rs3410068475 | 272 | V>I | No | EVA | |
| rs3389574278 | 273 | E>K | No | EVA | |
| rs3389553415 | 274 | Y>* | No | EVA | |
| rs3389564006 | 291 | L>Q | No | EVA | |
| rs3389515629 | 295 | K>E | No | EVA | |
| rs3410068459 | 297 | S>T | No | EVA | |
| rs3389568855 | 309 | L>P | No | EVA | |
| rs3389526519 | 315 | K>R | No | EVA | |
| rs3410176141 | 350 | Q>E | No | EVA | |
| rs3389564012 | 367 | N>K | No | EVA | |
| rs3410176087 | 389 | F>S | No | EVA | |
| rs3410543751 | 393 | L>V | No | EVA | |
| rs3410794945 | 394 | E>V* | No | EVA | |
| rs3410068535 | 395 | H>N | No | EVA | |
| rs3410290476 | 396 | S>A | No | EVA | |
| rs3410543801 | 401 | E>K | No | EVA | |
| rs3410794897 | 402 | A>V | No | EVA | |
| rs3410378940 | 406 | H>N | No | EVA | |
| rs3410221324 | 406 | H>Q | No | EVA | |
| rs3410176094 | 408 | S>C | No | EVA | |
| rs3389508375 | 412 | S>Y | No | EVA | |
| rs3389538954 | 454 | S>I | No | EVA | |
| rs3389526594 | 467 | V>I | No | EVA | |
| rs3389552880 | 478 | D>Y | No | EVA | |
| rs3410320917 | 488 | V>M | No | EVA | |
| rs3389515552 | 515 | S>N | No | EVA | |
| rs3410794788 | 522 | R>K | No | EVA | |
| rs3389526567 | 522 | R>S | No | EVA | |
| rs3389553397 | 525 | R>G | No | EVA | |
| rs3389508341 | 525 | R>S | No | EVA | |
| rs3389571551 | 552 | I>N | No | EVA | |
| rs30272012 | 587 | T>S | No | EVA | |
| rs3410171541 | 611 | L>R | No | EVA | |
| rs3389560242 | 619 | Q>* | No | EVA | |
| rs3389564002 | 620 | E>D | No | EVA | |
| rs3389552112 | 645 | E>D | No | EVA | |
| rs3389467162 | 649 | P>T | No | EVA | |
| rs3410220034 | 675 | L>Q | No | EVA | |
| rs3389568913 | 689 | A>V | No | EVA |
No associated diseases with A2AD83
15 regional properties for A2AD83
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 615 - 899 | IPR000719 |
| domain | Ephrin receptor ligand binding domain | 17 - 202 | IPR001090 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 616 - 874 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class V, conserved site | 178 - 198 | IPR001426-1 |
| conserved_site | Tyrosine-protein kinase, receptor class V, conserved site | 239 - 260 | IPR001426-2 |
| domain | Sterile alpha motif domain | 904 - 971 | IPR001660 |
| domain | Fibronectin type III | 323 - 432 | IPR003961-1 |
| domain | Fibronectin type III | 434 - 529 | IPR003961-2 |
| active_site | Tyrosine-protein kinase, active site | 736 - 748 | IPR008266 |
| domain | Tyrosine-protein kinase ephrin type A/B receptor-like | 258 - 299 | IPR011641 |
| binding_site | Protein kinase, ATP binding site | 621 - 647 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 615 - 874 | IPR020635 |
| domain | Ephrin receptor, transmembrane domain | 541 - 612 | IPR027936 |
| domain | Ephrin type-B receptor 4, ligand binding domain | 17 - 196 | IPR034290 |
| domain | EPH-B4, SAM domain | 907 - 973 | IPR037636 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| growth cone | The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of protein binding | Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. |
| negative regulation of stress fiber assembly | Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| positive regulation of lamellipodium assembly | Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. |
| positive regulation of small GTPase mediated signal transduction | Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction. |
| regulation of neuron projection development | Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32LP2 | RDX | Radixin | Bos taurus (Bovine) | SS |
| P31976 | EZR | Ezrin | Bos taurus (Bovine) | PR |
| Q2HJ49 | MSN | Moesin | Bos taurus (Bovine) | PR |
| Q9PU45 | RDX | Radixin | Gallus gallus (Chicken) | PR |
| F1P065 | FARP1 | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Gallus gallus (Chicken) | SS |
| P46150 | Moe | Moesin/ezrin/radixin homolog 1 | Drosophila melanogaster (Fruit fly) | SS |
| Q24564 | Mer | Moesin/ezrin/radixin homolog 2 | Drosophila melanogaster (Fruit fly) | SS |
| P35240 | NF2 | Merlin | Homo sapiens (Human) | EV |
| P26038 | MSN | Moesin | Homo sapiens (Human) | EV |
| P15311 | EZR | Ezrin | Homo sapiens (Human) | EV |
| P35241 | RDX | Radixin | Homo sapiens (Human) | SS |
| Q3KP66 | INAVA | Innate immunity activator protein | Homo sapiens (Human) | PR |
| O94887 | FARP2 | FERM, ARHGEF and pleckstrin domain-containing protein 2 | Homo sapiens (Human) | SS |
| Q9Y4F1 | FARP1 | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Homo sapiens (Human) | SS |
| P26043 | Rdx | Radixin | Mus musculus (Mouse) | SS |
| P26040 | Ezr | Ezrin | Mus musculus (Mouse) | SS |
| P46662 | Nf2 | Merlin | Mus musculus (Mouse) | SS |
| P26041 | Msn | Moesin | Mus musculus (Mouse) | SS |
| F8VPU2 | Farp1 | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q91VS8 | Farp2 | FERM, ARHGEF and pleckstrin domain-containing protein 2 | Mus musculus (Mouse) | EV |
| P26042 | MSN | Moesin | Sus scrofa (Pig) | PR |
| P26044 | RDX | Radixin | Sus scrofa (Pig) | SS |
| Q63648 | Nf2 | Merlin | Rattus norvegicus (Rat) | SS |
| P31977 | Ezr | Ezrin | Rattus norvegicus (Rat) | SS |
| O35763 | Msn | Moesin | Rattus norvegicus (Rat) | SS |
| F1LYQ8 | Farp1 | FERM, ARHGEF and pleckstrin domain-containing protein 1 | Rattus norvegicus (Rat) | SS |
| Q6Q413 | nf2b | NF2, moesin-ezrin-radixin-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLHLKVQFLD | DSQKIFVVDQ | KSSGKALFNL | SCGHLNLAEK | EYFGLEFCSH | SGNNVWLELL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KPITKQVKNP | KEVVFKFMVK | FFPVDPGHLR | EELTRYLFTL | QIKKDLALGR | LPCSDNCTAL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MVSHILQSEL | GDFHEETVRK | HLVQTQYLPS | QASLESKIMQ | FHQQHIGRSP | AESDILLLDI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARKLDMYGIR | PQPASDGEGM | QIHLAVAHMG | VLVLRGNTKI | NTFNWAKIRK | LSFKRKHFLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KLHANILVLC | KDTLEFTMAS | RDACKAFWKT | CVEYHAFFRL | SEEPKSKPKT | LLCSKGSSFR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YSGRTQRQLL | EYGKKGRLKS | LPFERKQYPS | QYHERQCRSS | PDILSDVSKQ | VEDLRLTYGS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SYYRNVNGVH | ASESMLDSRR | RNSAVEVTFA | AELEHSKPEA | EATSLHPSQS | SSSFTFIYAD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PVFNTDPEPI | EFFEERSPLS | SFQTTSKFAD | SHTSKASPAR | QLTYTDVPYI | PCTSQKVDIM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PPQVFFYVDK | PPQVPRRSLI | MAEENMRPDS | YVDHSAIKPA | KRSPRNMRIK | SLQQDLQELQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EAMARTSGRS | NINVEPEEED | PHLDDAFAYN | LQEQTPKRSQ | SQSDMKTIRF | PFGSEFRPLG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PCPALTRKTD | LFACTFAEQE | FPTVLIDQSS | AERYVASESS | DSESEIIKPD | YYFLYGKGTK |
| 670 | 680 | 690 | 700 | ||
| SPRARIRLSS | GSLQLEEEDE | TISFATPGAE | DRTLLKPCNY | FLA |