A2A5R2

PR
Gene name
Arfgef2 (Arfgep2, Big2)
Protein name
Brefeldin A-inhibited guanine nucleotide-exchange protein 2
Names
Brefeldin A-inhibited GEP 2, ADP-ribosylation factor guanine nucleotide-exchange factor 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:99371
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2A5R2

Entry ID Method Resolution Chain Position Source
AF-A2A5R2-F1 Predicted AlphaFoldDB

87 variants for A2A5R2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388614666 54 A>P No EVA
rs3388610624 67 K>R No EVA
rs3388613587 79 K>R No EVA
rs3388610635 83 V>M No EVA
rs3388610744 160 L>M No EVA
rs3388614617 166 C>S No EVA
rs3388604837 175 N>K No EVA
rs3388615617 236 S>R No EVA
rs225607294 265 L>S No EVA
rs265305857 277 P>S No EVA
rs3388608927 279 S>Y No EVA
rs225991388 286 R>M No EVA
rs3388616386 293 Q>H No EVA
rs3392563694 304 V>I No EVA
rs3388604795 310 E>K No EVA
rs3388610000 319 E>D No EVA
rs3388611688 323 A>T No EVA
rs3388616404 333 A>T No EVA
rs3388599059 399 G>E No EVA
rs3388616343 409 R>H No EVA
rs3388611730 412 V>M No EVA
rs3388606824 422 L>M No EVA
rs3388614667 432 H>Q No EVA
rs3388608933 459 F>I No EVA
rs3388606803 478 K>T No EVA
rs3388610647 500 F>I No EVA
rs3388616398 521 V>A No EVA
rs3388609984 556 L>V No EVA
rs3388608952 593 N>S No EVA
rs3388598933 598 L>P No EVA
rs27295634 636 A>T No EVA
rs3388605637 649 Q>* No EVA
rs3388614605 666 K>* No EVA
rs3388616499 669 I>F No EVA
rs3388611739 693 E>G No EVA
rs3388598998 715 M>I No EVA
rs3388614457 719 V>L No EVA
rs3388608923 720 D>Y No EVA
rs3392470493 742 L>Q No EVA
rs3388604770 743 P>H No EVA
rs3388610670 766 G>R No EVA
rs3388608929 812 N>K No EVA
rs3388613567 838 E>* No EVA
rs27295598 843 T>S No EVA
rs3388605611 905 W>* No EVA
rs3388614581 907 P>Q No EVA
rs3388609949 920 D>E No EVA
rs3388604766 920 D>N No EVA
rs3388613545 920 D>V No EVA
rs3388608943 962 T>I No EVA
rs3388614623 1027 E>K No EVA
rs3388616331 1099 R>S No EVA
rs3388605701 1101 L>M No EVA
rs3388615571 1111 S>Y No EVA
rs3413053033 1112 P>S No EVA
rs3388614463 1125 E>* No EVA
rs3388610030 1133 R>K No EVA
rs3392570287 1135 R>Q No EVA
rs3388615594 1147 D>V No EVA
rs3388613539 1153 G>D No EVA
rs3388611718 1155 N>K No EVA
rs3388609964 1156 P>T No EVA
rs3388610017 1158 E>G No EVA
rs3388609982 1198 M>V No EVA
rs3388610738 1204 P>Q No EVA
rs3388614648 1253 Q>K No EVA
rs3388616350 1253 Q>P No EVA
rs3388610723 1260 S>L No EVA
rs3388609960 1265 H>Y No EVA
rs3388610805 1278 V>A No EVA
rs3388599012 1278 V>M No EVA
rs3388614598 1313 R>W No EVA
rs3388616381 1317 E>K No EVA
rs3388605674 1346 I>N No EVA
rs3388604814 1377 W>* No EVA
rs3412926108 1475 D>G No EVA
rs3388616489 1494 L>Q No EVA
rs3392434090 1538 T>I No EVA
rs3413110801 1544 G>R No EVA
rs3388615547 1553 L>P No EVA
rs3388616429 1556 L>F No EVA
rs3392536649 1660 K>A No EVA
rs3388610706 1700 A>T No EVA
rs3388617309 1709 S>P No EVA
rs3388598989 1726 K>N No EVA
rs3388604764 1773 Y>N No EVA
rs3388614591 1787 A>T No EVA

No associated diseases with A2A5R2

2 regional properties for A2A5R2

Type Name Position InterPro Accession
domain Protein kinase domain 88 - 396 IPR000719
active_site Serine/threonine-protein kinase, active site 209 - 221 IPR008271

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Membrane
  • Golgi apparatus
  • Cytoplasm, perinuclear region
  • Golgi apparatus, trans-Golgi network
  • Endosome
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Cell projection, dendrite
  • Cytoplasmic vesicle
  • Synapse
  • Cytoplasm, cytoskeleton
  • Translocates from cytoplasm to membranes upon cAMP treatment
  • Localized in recycling endosomes (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

16 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
asymmetric synapse A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory.
axonemal microtubule A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
symmetric synapse A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typcially inhibitory.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

4 GO annotations of molecular function

Name Definition
GABA receptor binding Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
myosin binding Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
protein kinase A regulatory subunit binding Binding to one or both of the regulatory subunits of protein kinase A.

9 GO annotations of biological process

Name Definition
endomembrane system organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.
endosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
Golgi to plasma membrane transport The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
positive regulation of tumor necrosis factor production Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
receptor recycling The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.
regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O46382 ARFGEF1 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 Bos taurus (Bovine) PR
Q9Y6D5 ARFGEF2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 Homo sapiens (Human) PR
Q9Y6D6 ARFGEF1 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 Homo sapiens (Human) PR
G3X9K3 Arfgef1 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 Mus musculus (Mouse) PR
Q3TES0 Iqsec3 IQ motif and SEC7 domain-containing protein 3 Mus musculus (Mouse) SS
Q80YW0 Cyth4 Cytohesin-4 Mus musculus (Mouse) SS
O08967 Cyth3 Cytohesin-3 Mus musculus (Mouse) EV
Q8R0S2 Iqsec1 IQ motif and SEC7 domain-containing protein 1 Mus musculus (Mouse) SS
P63034 Cyth2 Cytohesin-2 Mus musculus (Mouse) SS
Q9QX11 Cyth1 Cytohesin-1 Mus musculus (Mouse) SS
Q5DU25 Iqsec2 IQ motif and SEC7 domain-containing protein 2 Mus musculus (Mouse) SS
D4A631 Arfgef1 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 Rattus norvegicus (Rat) PR
Q7TSU1 Arfgef2 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MQESQTKSMF VSRALEKILA DKEVKRPQHS QLRRACQVAL DEIKAELEKQ RLGAAAPPKA
70 80 90 100 110 120
NFIEADKYFL PFELACQSKS PRVVSTSLDC LQKLIAYGHI TGNAPDSGAP GKRLIDRIVE
130 140 150 160 170 180
TICNCFQGPQ TDEGVQLQII KALLTAVTSP HIEIHEGTIL QTVRTCYNIY LASKNLINQT
190 200 210 220 230 240
TAKATLTQML NVIFTRMENQ VLQEARELEK PMQSKPQSPV IQATAGSPKF SRLKQSQAQS
250 260 270 280 290 300
KPTTPEKAEL PNGDHAQSGL GKVSLENGEA PRERGSPVSG RAEPSRGTDS GAQEVVKDIL
310 320 330 340 350 360
EDVVTSAVKE AAEKHGLPEP DRALGALECQ ECAVPPGVDE NSQTNGIADD RQSLSSADNL
370 380 390 400 410 420
EPDVQGHQVA ARFSHILQKD AFLVFRSLCK LSMKPLGEGP PDPKSHELRS KVVSLQLLLS
430 440 450 460 470 480
VLQNAGPVFR SHEMFVTAIK QYLCVALSKN GVSSVPDVFE LSLAIFLTLL SNFKMHLKMQ
490 500 510 520 530 540
IEVFFKEIFL NILETSTSSF EHRWMVIQTL TRICADAQCV VDIYVNYDCD LNAANIFERL
550 560 570 580 590 600
VNDLSKIAQG RSGHELGMTP LQELSLRKKG LECLVSILKC MVEWSKDLYV NPNHQATLGQ
610 620 630 640 650 660
ERLPDQEMGD GKGLDMARRC SVTSVESTVS SGTQTAIQDD PEQFEVIKQQ KEIIEHGIEL
670 680 690 700 710 720
FNKKPKRGIQ FLQEQGMLGA AVEDIAQFLH QEERLDSTQV GEFLGDSTRF NKEVMYAYVD
730 740 750 760 770 780
QLDFCEKEFV SALRTFLEGF RLPGEAQKID RLMEKFAARY IECNQGQTLF ASADTAYVLA
790 800 810 820 830 840
YSIIMLTTDL HSPQVKNKMT KEQYIKMNRG INDSKDLPEE YLSSIYDEIE GKKIAMKETK
850 860 870 880 890 900
EHTIATKSTK QSVASEKQRR LLYNVEMEQM AKTAKALMEA VSHAKAPFTS ATHLDHVRPM
910 920 930 940 950 960
FKLVWTPLLA AYSIGLQNCD DTEVASLCLE GIRCAVRIAC IFGMQLERDA YVQALARFSL
970 980 990 1000 1010 1020
LTASSSITEM KQKNIDTIKT LITVAHTDGN YLGNSWHEIL KCISQLELAQ LIGTGVKTRY
1030 1040 1050 1060 1070 1080
LSGSGREREG SLKGHSLAGE EFMGLGLGNL VSGGVDKRQM ASFQESVGET SSQSVVVAVD
1090 1100 1110 1120 1130 1140
RIFTGSTRLD GNAIVDFVRW LCAVSMDELA SPHHPRMFSL QKIVEISYYN MNRIRLQWSR
1150 1160 1170 1180 1190 1200
IWHVIGDHFN KVGCNPNEDV AIFAVDSLRQ LSMKFLEKGE LANFRFQKDF LRPFEHIMKK
1210 1220 1230 1240 1250 1260
NRSPTIRDMV IRCIAQMVSS QAANIRSGWK NIFAVFHQAA SDHDGNIVEL AFQTTGHIVS
1270 1280 1290 1300 1310 1320
TIFQHHFPAA IDSFQDAVKC LSEFACNAAF PDTSMEAIRL IRFCGKYVSE RPRVLQEYTS
1330 1340 1350 1360 1370 1380
DDMNVAPGDR VWVRGWFPIL FELSCIINRC KLDVRTRGLT VMFEIMKSYG HTFAKHWWQD
1390 1400 1410 1420 1430 1440
LFRIVFRIFD NMKLPEQQSE KSEWMTTTCN HALYAICDVF TQFYEALHEV LLSDVFAQLQ
1450 1460 1470 1480 1490 1500
WCVKQDNEQL ARSGTNCLEN LVISNGEKFS PAVWDETCNC MLDIFKTTIP HVLLTWRPAG
1510 1520 1530 1540 1550 1560
MEEEVSDRHL DVDLDRQSLS SIDRNASERG QSQLSNPTDD SWKGAPYAHQ KLLASLLIKC
1570 1580 1590 1600 1610 1620
VVQLELIQTI DNIVFYPATS KKEDAEHMVA AQQDTLDAEI HIETENQGMY KFMSSQHLFK
1630 1640 1650 1660 1670 1680
LLDCLQESHS FSKAFNSNYE QRTVLWRAGF KGKSKPNLLK QETSSLACCL RILFRMYVDE
1690 1700 1710 1720 1730 1740
NRRDSWDEIQ QRLLRVCSEA LAYFITVNSE SHREAWTSLL LLLLTKTLKI SDEKFKAHAS
1750 1760 1770 1780 1790
MYYPYLCEIM QFDLIPELRA VLRKFFLRIG LVYKIWIPEE PSQVPAALSS TW