A2A5C2

EV
Gene name
Etv4
Protein name
ETS translocation variant 4
Names
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class
ETS (PTHR11849)

Descriptions

Etv4 is a transcriptional activator playing a role in keratinocyte differentiation. Truncation of the autoinhibitory regions increases the transcriptional and DNA binding activities of Etv4. The autoinhibition of Etv4 is mediated by elements outside of ETS domain, and exists in two conformations: a closed, inhibited form and an open, active form that is competent to bind to DNA.

Autoinhibitory domains (AIDs)

1-42 (N-terminal autoinhibitory region) EV

Target domain

334-417 (ETS domain)

Relief mechanism

Partner binding

Assay

Deletion assay

417-480 (C-terminal autoinhibitory region) EV

Target domain

334-417 (ETS domain)

Relief mechanism

Partner binding

Assay

Deletion assay, Mutagenesis experiment

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A2A5C2

Entry ID Method Resolution Chain Position Source
AF-A2A5C2-F1 Predicted AlphaFoldDB

5 variants for A2A5C2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs260245572 66 A>V No Ensembl
rs235382712 103 R>C No Ensembl
rs234101126 220 N>S No Ensembl
rs28234792 322 I>F No Ensembl
rs28234799 473 G>S No Ensembl

No associated diseases with A2A5C2

26 regional properties for A2A5C2

Type Name Position InterPro Accession
domain Dbl homology (DH) domain 1281 - 1456 IPR000219-1
domain Dbl homology (DH) domain 1929 - 2104 IPR000219-2
domain Protein kinase domain 2684 - 2938 IPR000719
domain CRAL-TRIO lipid binding domain 35 - 181 IPR001251
domain SH3 domain 1646 - 1711 IPR001452-1
domain SH3 domain 2321 - 2386 IPR001452-2
domain Pleckstrin homology domain 1468 - 1582 IPR001849-1
domain Pleckstrin homology domain 2116 - 2228 IPR001849-2
repeat Spectrin repeat 311 - 414 IPR002017-1
repeat Spectrin repeat 540 - 640 IPR002017-2
repeat Spectrin repeat 891 - 998 IPR002017-3
repeat Spectrin repeat 1132 - 1227 IPR002017-4
domain Immunoglobulin subtype 2 2483 - 2555 IPR003598
domain Immunoglobulin subtype 2477 - 2566 IPR003599
domain Fibronectin type III 2569 - 2665 IPR003961
domain Immunoglobulin-like domain 2471 - 2564 IPR007110
active_site Serine/threonine-protein kinase, active site 2799 - 2811 IPR008271
domain Immunoglobulin I-set 2471 - 2565 IPR013098
binding_site Protein kinase, ATP binding site 2690 - 2713 IPR017441
repeat Spectrin/alpha-actinin 190 - 536 IPR018159-1
repeat Spectrin/alpha-actinin 537 - 766 IPR018159-2
repeat Spectrin/alpha-actinin 891 - 1129 IPR018159-3
repeat Spectrin/alpha-actinin 1133 - 1235 IPR018159-4
domain Kalirin/Triple functional domain protein, SH3 domain 1 1649 - 1708 IPR028570
domain Kalirin/Triple functional domain protein, SH3 domain 2 2325 - 2383 IPR047053
domain Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1 1461 - 1583 IPR047054

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family PTHR11849 ETS
PANTHER Subfamily PTHR11849:SF181 ETS TRANSLOCATION VARIANT 4
PANTHER Protein Class DNA-binding transcription factor
helix-turn-helix transcription factor
winged helix/forkhead transcription factor
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

1 GO annotations of biological process

Name Definition
positive regulation of transcription, DNA-templated Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MERRMKGGYL DQRVPYTFCS KSPGNGSLGE ALMVPQGKLM DPGSLPPSDS EDLFQDLSHF
70 80 90 100 110 120
QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ SPRTDPALSC SRKPPLPYHH
130 140 150 160 170 180
GEQCLYSRQI AIKSPAPGAP GQSPLQPFSR AEQQQSLLRA SSSSQSHPGH GYLGEHSSVF
190 200 210 220 230 240
QQPVDMCHSF TSPQGGGREP LPAPYQHQLS EPCPPYPQQN FKQEYHDPLY EQAGQPASSQ
250 260 270 280 290 300
GGVSGHRYPG AGVVIKQERT DFAYDSDVPG CASMYLHPEG FSGPSPGDGV MGYGYEKSLR
310 320 330 340 350 360
PFPDDVCIVP EKFEGDIKQE GIGAFREGPP YQRRGALQLW QFLVALLDDP TNAHFIAWTG
370 380 390 400 410 420
RGMEFKLIEP EEVARLWGIQ KNRPAMNYDK LSRSLRYYYE KGIMQKVAGE RYVYKFVCEP
430 440 450 460 470
EALFSLAFPD NQRPALKAEF DRPVSEEDTV PLSHLDESPA YLPELTGPAP PFGHRGGYSY