A1Z7A6
Gene name |
Asap (Asap1, CG30372) |
Protein name |
ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG30372 |
EC number |
|
Protein Class |
|

Descriptions
Autoinhibitory domains (AIDs)
Target domain |
312-401 (PH domain);427-549 (Arf GAP domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure

Activated structure

1 structures for A1Z7A6
Entry ID | Method | Resolution | Chain | Position | Source |
---|---|---|---|---|---|
AF-A1Z7A6-F1 | Predicted | AlphaFoldDB |
No variants for A1Z7A6
Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
---|---|---|---|---|---|
No variants for A1Z7A6 |
No associated diseases with A1Z7A6
7 regional properties for A1Z7A6
Type | Name | Position | InterPro Accession |
---|---|---|---|
domain | Arf GTPase activating protein | 427 - 547 | IPR001164 |
domain | SH3 domain | 1091 - 1155 | IPR001452 |
domain | Pleckstrin homology domain | 310 - 406 | IPR001849 |
repeat | Ankyrin repeat | 556 - 663 | IPR002110 |
domain | BAR domain | 32 - 267 | IPR004148 |
domain | ASAP1-like, SH3 domain | 1095 - 1149 | IPR035836 |
domain | ASAP, PH domain | 302 - 410 | IPR037844 |
Functions
5 GO annotations of cellular component
Name | Definition |
---|---|
apical part of cell | The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. |
cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
microvillus | Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. |
nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
Name | Definition |
---|---|
GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
metal ion binding | Binding to a metal ion. |
phosphatidylinositol phosphate binding | Binding to phosphatidylinositol phosphate. |
5 GO annotations of biological process
Name | Definition |
---|---|
compound eye morphogenesis | The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster. |
mitotic cleavage furrow ingression | Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed. |
positive regulation of protein localization | Any process that activates or increases the frequency, rate or extent of a protein localization. |
regulation of Golgi organization | Any process that modulates the frequency, rate or extent of Golgi organization. |
regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
15 homologous proteins in AiPD
UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
---|---|---|---|---|
A5PK26 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
O97902 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
Q15027 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
Q15057 | ACAP2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | PR |
Q9ULH1 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
Q8TDY4 | ASAP3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Homo sapiens (Human) | SS |
O43150 | ASAP2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | SS |
Q8K2H4 | Acap1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
Q6ZQK5 | Acap2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Mus musculus (Mouse) | PR |
Q9QWY8 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
Q7SIG6 | Asap2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Mus musculus (Mouse) | SS |
Q5U464 | Asap3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Mus musculus (Mouse) | SS |
Q1AAU6 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Rattus norvegicus (Rat) | SS |
Q9C6C3 | AGD2 | ADP-ribosylation factor GTPase-activating protein AGD2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
Q9SMX5 | AGD4 | ADP-ribosylation factor GTPase-activating protein AGD4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
10 | 20 | 30 | 40 | 50 | 60 |
MPPSLIAVSE | FVEETRSDYS | SPTTSTFASR | MPDCRHTIGV | LEERLEFDRE | GLTKLKKAVK |
70 | 80 | 90 | 100 | 110 | 120 |
AIHNSGNTHV | DNEMFMVRAL | ERLGGKVIEQ | DEPDIGAAFL | KFSVVTKELS | ALMKTLMQNI |
130 | 140 | 150 | 160 | 170 | 180 |
NNIVMFPVDS | MLKSELRGVK | GDMKRPFDKA | AKDYEAKFIK | IEKEKKAQAK | EAGMVRTEID |
190 | 200 | 210 | 220 | 230 | 240 |
AAVVAEEMEK | ERRLYQLQTC | EYLLKYKDIK | TKTGIELLQH | LIEYYHALSN | YFKDGLQTIE |
250 | 260 | 270 | 280 | 290 | 300 |
HFGTYIGDLS | EKLHEIKQKQ | DEDRRSLLDL | RTVLRSTPDF | ERVDNVPSSE | SRSGGAGYSL |
310 | 320 | 330 | 340 | 350 | 360 |
HQLQGDKHHG | VTRQGHLLKK | SEGKVRRVWQ | KRRCRVTSDG | FLDIFHADES | KPPTRVNLLT |
370 | 380 | 390 | 400 | 410 | 420 |
CQIKPVPDDK | RGFDLISYNR | PYHFQAEDEG | DQKAWMAVLV | NCKEKALTKA | FQHANPQMSP |
430 | 440 | 450 | 460 | 470 | 480 |
SLVELQKTVI | RYVQLLPGND | RCCDCGSRND | VTWISLNFGI | LVCIQCSGVH | RDLGVHHSRI |
490 | 500 | 510 | 520 | 530 | 540 |
QSLTLDNLTT | ANLLIARAMG | NSTLNDIMEA | KLGRGKLQHE | SSMEERYDFI | RAKYVAKRYV |
550 | 560 | 570 | 580 | 590 | 600 |
MRTCSDDNDL | RCDLEQAVVN | ADMSQLLQVW | AEGADLTCCL | PSSDAGETAL | HLAVLREMGS |
610 | 620 | 630 | 640 | 650 | 660 |
TLHIVDFLIQ | NMPPKGLNKA | TNPAGLLDVT | GKNTALHLCA | LHDRRECMKL | LLRSGADYEL |
670 | 680 | 690 | 700 | 710 | 720 |
KNSQNKTALD | IAKEMGHNSC | RELIECAIKR | EKSAFDHINT | DWNLPNEDGS | TDFSDDETVI |
730 | 740 | 750 | 760 | 770 | 780 |
DERKSRSRPP | SFAGGDSPVL | RSRSSTCDSI | QSSSSPIANC | PSRQFTLPSG | LPSYTHSAGT |
790 | 800 | 810 | 820 | 830 | 840 |
SPKQHISVGQ | YLGSATNVGG | NGPGNGGSSP | SSASSQSVRA | ARNSLNMQSD | LGGHVTGARK |
850 | 860 | 870 | 880 | 890 | 900 |
STSTANMNSL | KKRTAPAPPP | GTLGSASSSS | FYGTLPHPPR | HSQNFDASDI | RAINHKNQSL |
910 | 920 | 930 | 940 | 950 | 960 |
DVAYGTLPHL | RSVESSPRGG | GGYGYGVSQD | PGGSGNGSNN | SLMPAMTTFG | HKRSPSGESL |
970 | 980 | 990 | 1000 | 1010 | 1020 |
NRNIHLAGAK | LVLPPTGELP | TLKHVDKSAL | TRPKIPPPGP | PSEREISNGQ | SNESISSMDE |
1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
GPVAPPRKLV | NQSANFPDYE | SWHTDMDSSG | GGLDHSAESN | VSSSDNDRLN | SSPDNPSKTG |
1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
GAGLGGKFHY | NGQRRCRALY | DCVADNDDEL | EFKEGEILIV | LNERTDDENW | MEGIIEGQPT |
1150 | |||||
RKGMFPVSFV | HMLPD |