A1L1L3

PR
Gene name
Ptpn20
Protein name
Tyrosine-protein phosphatase non-receptor type 20
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:306281
EC number
3.1.3.48: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-222 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A1L1L3

Entry ID Method Resolution Chain Position Source
AF-A1L1L3-F1 Predicted AlphaFoldDB

No variants for A1L1L3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A1L1L3

No associated diseases with A1L1L3

2 regional properties for A1L1L3

Type Name Position InterPro Accession
domain Protein kinase domain 53 - 314 IPR000719
binding_site Protein kinase, ATP binding site 59 - 82 IPR017441

Functions

Description
EC Number 3.1.3.48 Phosphoric monoester hydrolases
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
  • Colocalizes with the microtubule-organizing center and intracellular membrane compartments
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

1 GO annotations of biological process

Name Definition
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P17706 PTPN2 Tyrosine-protein phosphatase non-receptor type 2 Homo sapiens (Human) EV
P18031 PTPN1 Tyrosine-protein phosphatase non-receptor type 1 Homo sapiens (Human) PR
P35821 Ptpn1 Tyrosine-protein phosphatase non-receptor type 1 Mus musculus (Mouse) PR
Q06180 Ptpn2 Tyrosine-protein phosphatase non-receptor type 2 Mus musculus (Mouse) SS
P20417 Ptpn1 Tyrosine-protein phosphatase non-receptor type 1 Rattus norvegicus (Rat) PR
P35233 Ptpn2 Tyrosine-protein phosphatase non-receptor type 2 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MSSPGNVRQK HGRDNDEHEG DSDDLNLQKS LPSSSQQKTP TKPVFGNKVN SESVKTSHHM
70 80 90 100 110 120
SFSNKYDLVF PEPVESDNDE TLWDVRDLSH RNRWSSVDPE SAGPSKTVST VLSESSTDTA
130 140 150 160 170 180
VSERELTQLA QIRPLIFNSS SRAALRDCLK ALQKKEELDI IREFLELEEM IPPDDFKSGY
190 200 210 220 230 240
ELQNRDKNRY RDILPYDSTR VPLGKNKDYI NASYIRIVNH EEEYFYIATQ GPLPDTIEDF
250 260 270 280 290 300
WQMVLENNCN VIAMITREIE GGVIKCCSYW PVSLKEPLEF KHFHVLLENF QITQYFVIRI
310 320 330 340 350 360
FQIVKKSTGK SHSVKHLQFI KWPDHGTPAS ADFFIKYVRY VRKSHITGPL LVHCSAGVGR
370 380 390 400 410 420
TGVFICVDVV FCTIEKNYSF NIMNIVTQMR KQRFGMIQTK EQYQFCYEIV LEVLQNLLAL
N