A1L167
PR
Gene name |
UBE2QL1 |
Protein name |
Ubiquitin-conjugating enzyme E2Q-like protein 1 |
Names |
E2Q-like ubiquitin-conjugating enzyme 1 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:134111 |
EC number |
2.3.2.23: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A1L167
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A1L167-F1 | Predicted | AlphaFoldDB |
61 variants for A1L167
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1301606158 CA359162236 |
5 | Q>R | No |
ClinGen gnomAD |
|
|
CA113838306 rs910273767 |
6 | D>N | No |
ClinGen TOPMed |
|
|
rs1185838660 CA359162263 |
9 | R>H | No |
ClinGen TOPMed |
|
|
rs1294988130 CA359162273 |
11 | S>G | No |
ClinGen gnomAD |
|
|
CA359162337 rs1275696498 |
20 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
CA359162346 rs1316605377 |
21 | D>E | No |
ClinGen TOPMed |
|
|
rs897172833 CA113838321 |
21 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA3192076 rs768071851 |
23 | S>N | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 27 | W>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA359162410 rs1218745509 |
30 | K>R | No |
ClinGen TOPMed |
|
|
rs1266934035 CA359162433 |
33 | Q>H | No |
ClinGen gnomAD |
|
|
rs1488781198 CA359162441 |
35 | D>N | No |
ClinGen gnomAD |
|
|
rs533953288 CA113838389 |
43 | D>E | No |
ClinGen gnomAD |
|
|
CA113838369 rs566828528 |
43 | D>G | No |
ClinGen gnomAD |
|
|
CA359162506 rs1188626738 |
44 | M>V | No |
ClinGen gnomAD |
|
|
CA113838402 rs897668931 |
45 | K>R | No |
ClinGen TOPMed gnomAD |
|
|
CA359162587 rs1351942297 |
55 | N>S | No |
ClinGen gnomAD |
|
|
CA359162598 rs1444409143 |
57 | T>A | No |
ClinGen TOPMed |
|
|
CA113838407 rs929177176 |
60 | D>N | No |
ClinGen TOPMed |
|
|
rs1560924987 CA359162624 |
61 | N>H | No |
ClinGen Ensembl |
|
|
CA359162653 rs1383417766 |
64 | F>L | No |
ClinGen gnomAD |
|
|
CA359162682 rs1382332172 |
69 | M>V | No |
ClinGen gnomAD |
|
|
rs754063658 CA3192080 |
71 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA3192081 rs757490591 |
73 | S>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 74 | P>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 75 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1258952482 CA359162723 |
75 | R>L | No |
ClinGen gnomAD |
|
|
CA359162725 rs1183934766 |
76 | L>V | No |
ClinGen TOPMed gnomAD |
|
|
CA113838435 rs555830598 |
80 | Y>* | No |
ClinGen Ensembl |
|
|
CA3192082 rs765506914 |
83 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA359162815 rs1183275520 |
89 | M>I | No |
ClinGen gnomAD |
|
| TCGA novel | 90 | E>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1579283044 CA359162831 |
92 | L>I | No |
ClinGen Ensembl |
|
|
CA3192085 rs779914226 |
93 | T>M | No |
ClinGen ExAC gnomAD |
|
|
rs1424814892 CA359162837 |
93 | T>P | No |
ClinGen gnomAD |
|
|
CA359162920 rs1405393798 |
105 | A>D | No |
ClinGen gnomAD |
|
|
rs887717291 CA113838527 |
107 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
CA359162939 rs1380148119 |
108 | R>S | No |
ClinGen gnomAD |
|
|
rs1238148660 CA359162961 |
111 | A>S | No |
ClinGen TOPMed |
|
|
CA3192086 rs544533412 |
112 | A>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1331166089 CA359162974 |
113 | S>N | No |
ClinGen gnomAD |
|
|
rs1331166089 CA359162975 |
113 | S>T | No |
ClinGen gnomAD |
|
|
CA359163003 rs1579283086 |
118 | Q>* | No |
ClinGen Ensembl |
|
|
CA113868543 rs970644529 |
119 | G>V | No |
ClinGen TOPMed gnomAD |
|
|
CA359161862 rs1175775069 |
128 | S>P | No |
ClinGen TOPMed |
|
|
rs1166998889 CA359161890 |
129 | K>R | No |
ClinGen gnomAD |
|
|
rs976546887 CA113868565 |
130 | K>T | No |
ClinGen Ensembl |
|
| TCGA novel | 131 | S>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA359161958 rs1372626798 COSM1069367 |
134 | R>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs1430240147 CA359161962 |
134 | R>H | No |
ClinGen gnomAD |
|
|
rs1430240147 CA359161965 |
134 | R>L | No |
ClinGen gnomAD |
|
| TCGA novel | 135 | K>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA359162050 rs1348059258 |
142 | K>R | No |
ClinGen gnomAD |
|
|
CA113868578 rs753286846 |
151 | Y>H | No |
ClinGen Ensembl |
|
|
CA359162126 rs1207093475 |
153 | W>R | No |
ClinGen TOPMed |
|
|
CA359162144 rs1467386976 |
155 | T>N | No |
ClinGen TOPMed |
|
|
CA359162141 rs1579304980 |
155 | T>P | No |
ClinGen Ensembl |
|
| TCGA novel | 158 | V>L | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1299440822 CA359162159 |
158 | V>M | No |
ClinGen gnomAD |
|
|
rs1206322803 CA359162171 |
160 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA113868589 rs982730698 |
161 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen Ensembl NCI-TCGA |
No associated diseases with A1L167
4 regional properties for A1L167
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 119 - 403 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 240 - 252 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 125 - 149 | IPR017441 |
| domain | Glycogen synthase kinase 3, catalytic domain | 114 - 406 | IPR039192 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.23 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ubiquitin conjugating enzyme activity | Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein polyubiquitination | Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32L27 | UBE2Q2 | Ubiquitin-conjugating enzyme E2 Q2 | Bos taurus (Bovine) | PR |
| Q9H8T0 | AKTIP | AKT-interacting protein | Homo sapiens (Human) | PR |
| Q9Y385 | UBE2J1 | Ubiquitin-conjugating enzyme E2 J1 | Homo sapiens (Human) | PR |
| P61086 | UBE2K | Ubiquitin-conjugating enzyme E2 K | Homo sapiens (Human) | PR |
| Q9NPD8 | UBE2T | Ubiquitin-conjugating enzyme E2 T | Homo sapiens (Human) | PR |
| O00762 | UBE2C | Ubiquitin-conjugating enzyme E2 C | Homo sapiens (Human) | PR |
| O14933 | UBE2L6 | Ubiquitin/ISG15-conjugating enzyme E2 L6 | Homo sapiens (Human) | PR |
| Q96LR5 | UBE2E2 | Ubiquitin-conjugating enzyme E2 E2 | Homo sapiens (Human) | PR |
| Q969T4 | UBE2E3 | Ubiquitin-conjugating enzyme E2 E3 | Homo sapiens (Human) | PR |
| Q7Z7E8 | UBE2Q1 | Ubiquitin-conjugating enzyme E2 Q1 | Homo sapiens (Human) | PR |
| Q16763 | UBE2S | Ubiquitin-conjugating enzyme E2 S | Homo sapiens (Human) | EV |
| Q7TSS2 | Ube2q1 | Ubiquitin-conjugating enzyme E2 Q1 | Mus musculus (Mouse) | PR |
| A0PJN4 | Ube2ql1 | Ubiquitin-conjugating enzyme E2Q-like protein 1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKELQDIARL | SDRFISVELV | DESLFDWNVK | LHQVDKDSVL | WQDMKETNTE | FILLNLTFPD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NFPFSPPFMR | VLSPRLENGY | VLDGGAICME | LLTPRGWSSA | YTVEAVMRQF | AASLVKGQGR |
| 130 | 140 | 150 | 160 | ||
| ICRKAGKSKK | SFSRKEAEAT | FKSLVKTHEK | YGWVTPPVSD | G |