A1A4L6
SS
Gene name |
ETS2 |
Protein name |
Protein C-ets-2 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281148 |
EC number |
|
Protein Class |
|
Descriptions
Ets1 is a transcription factor directly controlling the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. Truncation of either the N-terminal inhibitory region (residues 280-330) or the C-terminal inhibitory region (residues 416-440) increases the DNA binding affinity of Ets-1 by 10- to 20-fold, indicating that the two inhibitory regions act in concert to impair DNA binding
Autoinhibitory domains (AIDs)
Target domain |
360-444 (ETS domain) |
Relief mechanism |
Partner binding |
Assay |
|
Target domain |
360-444 (ETS domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Garvie CW et al. (2002) "Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships", The Journal of biological chemistry, 277, 45529-36
- Nelson ML et al. (2010) "Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP", Proceedings of the National Academy of Sciences of the United States of America, 107, 10026-31
- Ning S et al. (2022) "The auto-inhibition mechanism of transcription factor Ets-1 induced by phosphorylation on the intrinsically disordered region", Computational and structural biotechnology journal, 20, 1132-1141
- Newman JA et al. (2015) "Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2", The Journal of biological chemistry, 290, 8539-49
- Samorodnitsky D et al. (2015) "A Role for Autoinhibition in Preventing Dimerization of the Transcription Factor ETS1", The Journal of biological chemistry, 290, 22101-10
- Basuyaux JP et al. (1997) "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner", The Journal of biological chemistry, 272, 26188-95
- Shiina M et al. (2015) "A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions", Journal of molecular biology, 427, 1655-69
- Babayeva ND et al. (2010) "Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA", Cell cycle (Georgetown, Tex.), 9, 3054-62
- Leprivier G et al. (2009) "Ets-1 p51 and p42 isoforms differentially modulate Stromelysin-1 promoter according to induced DNA bend orientation", Nucleic acids research, 37, 4341-52
Autoinhibited structure
Activated structure
1 structures for A1A4L6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A1A4L6-F1 | Predicted | AlphaFoldDB |
124 variants for A1A4L6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs479977388 | 32 | F>V | No | EVA | |
| rs483328204 | 63 | S>A | No | EVA | |
| rs443948270 | 64 | A>S | No | EVA | |
| rs451326257 | 67 | E>* | No | EVA | |
| rs462141030 | 72 | T>P | No | EVA | |
| rs480657102 | 77 | A>S | No | EVA | |
| rs447743377 | 78 | V>L | No | EVA | |
| rs466286056 | 81 | Q>P | No | EVA | |
| rs470024195 | 86 | T>P | No | EVA | |
| rs470024195 | 86 | T>S | No | EVA | |
| rs455661108 | 88 | S>R | No | EVA | |
| rs434352534 | 90 | F>L | No | EVA | |
| rs452863871 | 91 | K>R | No | EVA | |
| rs471327692 | 92 | K>* | No | EVA | |
| rs438518850 | 92 | K>T | No | EVA | |
| rs476888527 | 94 | Q>E | No | EVA | |
| rs443886284 | 94 | Q>H | No | EVA | |
| rs480583870 | 95 | R>L | No | EVA | |
| rs462457778 | 95 | R>S | No | EVA | |
| rs441255220 | 97 | L>P | No | EVA | |
| rs459770856 | 99 | I>T | No | EVA | |
| rs478327432 | 100 | P>L | No | EVA | |
| rs876375418 | 119 | T>P | No | EVA | |
| rs438808272 | 125 | V>G | No | EVA | |
| rs475935822 | 127 | V>L | No | EVA | |
| rs442907085 | 138 | V>G | No | EVA | |
| rs460978421 | 151 | A>E | No | EVA | |
| rs436779108 | 197 | G>V | No | EVA | |
| rs455237140 | 201 | E>G | No | EVA | |
| rs473686566 | 202 | Q>L | No | EVA | |
| rs454241998 | 205 | Y>S | No | EVA | |
| rs718423107 | 206 | G>A | No | EVA | |
| rs110129677 | 212 | Y>* | No | EVA | |
| rs482990736 | 224 | A>G | No | EVA | |
| rs108955011 | 231 | L>I | No | EVA | |
| rs459436688 | 237 | F>C | No | EVA | |
| rs478046575 | 239 | M>L | No | EVA | |
| rs445061054 | 240 | F>C | No | EVA | |
| rs470111993 | 243 | A>P | No | EVA | |
| rs437092359 | 244 | R>P | No | EVA | |
| rs110937409 | 246 | N>S | No | EVA | |
| rs467247765 | 247 | T>P | No | EVA | |
| rs452995053 | 251 | N>H | No | EVA | |
| rs472730566 | 253 | C>S | No | EVA | |
| rs433392548 | 254 | S>Y | No | EVA | |
| rs451876876 | 255 | V>L | No | EVA | |
| rs462535740 | 273 | K>Q | No | EVA | |
| rs474607212 | 274 | P>T | No | EVA | |
| rs460223593 | 275 | R>T | No | EVA | |
| rs480016948 | 276 | D>E | No | EVA | |
| rs459174213 | 278 | D>E | No | EVA | |
| rs446986948 | 278 | D>G | No | EVA | |
| rs451139978 | 280 | A>E | No | EVA | |
| rs451139978 | 280 | A>G | No | EVA | |
| rs469170678 | 281 | E>G | No | EVA | |
| rs448529240 | 282 | T>P | No | EVA | |
| rs467013248 | 282 | T>R | No | EVA | |
| rs452208429 | 286 | S>R | No | EVA | |
| rs437857155 | 287 | F>L | No | EVA | |
| rs464396340 | 287 | F>S | No | EVA | |
| rs456432205 | 288 | E>G | No | EVA | |
| rs474570364 | 289 | S>R | No | EVA | |
| rs441608097 | 292 | S>* | No | EVA | |
| rs439333391 | 294 | L>R | No | EVA | |
| rs477419711 | 295 | Q>L | No | EVA | |
| rs477419711 | 295 | Q>R | No | EVA | |
| rs444655212 | 296 | S>A | No | EVA | |
| rs463110539 | 297 | W>S | No | EVA | |
| rs135514413 | 298 | N>T | No | EVA | |
| rs481554677 | 301 | S>A | No | EVA | |
| rs467035018 | 302 | S>P | No | EVA | |
| rs464307983 | 305 | D>A | No | EVA | |
| rs446133793 | 305 | D>Y | No | EVA | |
| rs437818757 | 306 | V>L | No | EVA | |
| rs3423127222 | 307 | Q>R | No | EVA | |
| rs456395340 | 309 | V>E | No | EVA | |
| rs456395340 | 309 | V>G | No | EVA | |
| rs435504854 | 311 | S>A | No | EVA | |
| rs472273564 | 313 | E>D | No | EVA | |
| rs453637567 | 313 | E>V | No | EVA | |
| rs439246617 | 317 | D>E | No | EVA | |
| rs470983476 | 321 | Q>H | No | EVA | |
| rs451305138 | 321 | Q>R | No | EVA | |
| rs444581451 | 326 | S>N | No | EVA | |
| rs463012408 | 329 | T>I | No | EVA | |
| rs481766752 | 337 | Q>P | No | EVA | |
| rs442345556 | 338 | D>G | No | EVA | |
| rs460460463 | 340 | S>N | No | EVA | |
| rs446069578 | 341 | D>A | No | EVA | |
| rs464674324 | 341 | D>E | No | EVA | |
| rs479057442 | 341 | D>H | No | EVA | |
| rs479057442 | 341 | D>Y | No | EVA | |
| rs483154443 | 345 | Q>E | No | EVA | |
| rs449883553 | 346 | G>D | No | EVA | |
| rs435472521 | 347 | K>R | No | EVA | |
| rs447558469 | 350 | I>M | No | EVA | |
| rs465680678 | 351 | P>L | No | EVA | |
| rs465680678 | 351 | P>R | No | EVA | |
| rs432792415 | 353 | A>P | No | EVA | |
| rs476089847 | 354 | V>G | No | EVA | |
| rs451266760 | 354 | V>L | No | EVA | |
| rs456562099 | 355 | L>V | No | EVA | |
| rs460871797 | 358 | F>C | No | EVA | |
| rs439616285 | 359 | T>K | No | EVA | |
| rs472545868 | 359 | T>P | No | EVA | |
| rs442669579 | 360 | G>A | No | EVA | |
| rs461219363 | 362 | G>V | No | EVA | |
| rs473005140 | 365 | Q>K | No | EVA | |
| rs458560605 | 367 | W>G | No | EVA | |
| rs482498697 | 390 | W>L | No | EVA | |
| rs463913856 | 390 | W>R | No | EVA | |
| rs449538981 | 391 | E>A | No | EVA | |
| rs468027111 | 396 | D>A | No | EVA | |
| rs453671682 | 400 | V>G | No | EVA | |
| rs472087333 | 405 | G>V | No | EVA | |
| rs452585240 | 408 | K>Q | No | EVA | |
| rs471009406 | 418 | L>F | No | EVA | |
| rs444648755 | 431 | I>M | No | EVA | |
| rs463288885 | 432 | H>P | No | EVA | |
| rs518737099 | 443 | F>L | No | EVA | |
| rs475338207 | 445 | C>G | No | EVA | |
| rs460579822 | 457 | E>D | No | EVA | |
| rs479105152 | 470 | D>G | No | EVA | |
| rs446164801 | 471 | D>L | No | EVA |
No associated diseases with A1A4L6
8 regional properties for A1A4L6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | BRCT domain | 380 - 461 | IPR001357 |
| domain | Zinc finger, PARP-type | 7 - 89 | IPR001510-1 |
| domain | Zinc finger, PARP-type | 111 - 200 | IPR001510-2 |
| domain | Poly(ADP-ribose) polymerase, regulatory domain | 644 - 776 | IPR004102 |
| domain | WGR domain | 525 - 622 | IPR008893 |
| domain | Poly(ADP-ribose) polymerase, catalytic domain | 770 - 994 | IPR012317 |
| domain | PARP1-like, PADR1 domain, zinc ribbon fold | 281 - 321 | IPR012982 |
| domain | PARP1-like, PADR1 domain, N-terminal helical subdomain | 222 - 280 | IPR049296 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
35 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2KIC2 | ETV1 | ETS translocation variant 1 | Bos taurus (Bovine) | SS |
| Q0VC65 | ETV6 | Transcription factor ETV6 | Bos taurus (Bovine) | SS |
| Q58DT0 | ELF5 | ETS-related transcription factor Elf-5 | Bos taurus (Bovine) | SS |
| P15062 | ETS1 | Transforming protein p68/c-ets-1 | Gallus gallus (Chicken) | SS |
| Q90837 | ERG | Transcriptional regulator Erg | Gallus gallus (Chicken) | SS |
| P10157 | ETS2 | Protein C-ets-2 | Gallus gallus (Chicken) | SS |
| A2T762 | ETV3 | ETS translocation variant 3 | Pan troglodytes (Chimpanzee) | PR |
| Q04688 | Ets97D | DNA-binding protein Ets97D | Drosophila melanogaster (Fruit fly) | PR |
| P50548 | ERF | ETS domain-containing transcription factor ERF | Homo sapiens (Human) | PR |
| P41970 | ELK3 | ETS domain-containing protein Elk-3 | Homo sapiens (Human) | SS |
| P41161 | ETV5 | ETS translocation variant 5 | Homo sapiens (Human) | SS |
| P43268 | ETV4 | ETS translocation variant 4 | Homo sapiens (Human) | EV |
| Q06546 | GABPA | GA-binding protein alpha chain | Homo sapiens (Human) | SS |
| P28324 | ELK4 | ETS domain-containing protein Elk-4 | Homo sapiens (Human) | EV |
| P41162 | ETV3 | ETS translocation variant 3 | Homo sapiens (Human) | PR |
| P14921 | ETS1 | Protein C-ets-1 | Homo sapiens (Human) | EV |
| P50549 | ETV1 | ETS translocation variant 1 | Homo sapiens (Human) | EV |
| P11308 | ERG | Transcriptional regulator ERG | Homo sapiens (Human) | EV |
| P19419 | ELK1 | ETS domain-containing protein Elk-1 | Homo sapiens (Human) | EV |
| P15036 | ETS2 | Protein C-ets-2 | Homo sapiens (Human) | EV |
| P41971 | Elk3 | ETS domain-containing protein Elk-3 | Mus musculus (Mouse) | EV |
| Q00422 | Gabpa | GA-binding protein alpha chain | Mus musculus (Mouse) | EV |
| P41969 | Elk1 | ETS domain-containing protein Elk-1 | Mus musculus (Mouse) | PR |
| P28322 | Etv4 | ETS translocation variant 4 | Mus musculus (Mouse) | SS |
| P27577 | Ets1 | Protein C-ets-1 | Mus musculus (Mouse) | EV |
| P70459 | Erf | ETS domain-containing transcription factor ERF | Mus musculus (Mouse) | PR |
| Q9CXC9 | Etv5 | ETS translocation variant 5 | Mus musculus (Mouse) | SS |
| P41158 | Elk4 | ETS domain-containing protein Elk-4 | Mus musculus (Mouse) | PR |
| P41164 | Etv1 | ETS translocation variant 1 | Mus musculus (Mouse) | SS |
| P81270 | Erg | Transcriptional regulator ERG | Mus musculus (Mouse) | SS |
| P15037 | Ets2 | Protein C-ets-2 | Mus musculus (Mouse) | SS |
| P41156 | Ets1 | Protein C-ets-1 | Rattus norvegicus (Rat) | SS |
| A4GTP4 | Elk1 | ETS domain-containing protein Elk-1 | Rattus norvegicus (Rat) | PR |
| Q9PUQ1 | etv4 | ETS translocation variant 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A3FEM2 | fev | Protein FEV | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNDFGIKNMD | QVAPVASSYR | GTLKRQAAFD | TFDGSLLAVF | PSLNEEQTLQ | EVPTGLDSIS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HDSANCELPL | LTPCSKAVMS | QALKATFSGF | KKEQRRLGIP | KNPWLWTEQQ | VCQWLLWATN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EFSLVDVNLQ | RFGMTGQVLC | NLGKERFLEL | APDFVGDILW | EHLEQMIKEN | QEKNEDQYEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NSHLNSVPHW | INSNSLGFGV | EQAPYGMQTQ | SYPKGGLLDG | LCPASSAPST | LGPEQDFQMF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKARLNTVSV | NYCSVGQDFP | AGSLNLLSSA | SGKPRDHDSA | ETGGDSFESS | ESLLQSWNSQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SSLLDVQRVP | SFESFEDDCS | QSLGLSKPTM | SFKDYIQDRS | DPVEQGKPVI | PAAVLAGFTG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SGPIQLWQFL | LELLSDKSCQ | SFISWTGDGW | EFKLADPDEV | ARRWGKRKNK | PKMNYEKLSR |
| 430 | 440 | 450 | 460 | ||
| GLRYYYDKNI | IHKTSGKRYV | YRFVCDLQNL | LGFTPEELHA | ILGVQPDTED |