A0PJN4

PR
Gene name
Ube2ql1
Protein name
Ubiquitin-conjugating enzyme E2Q-like protein 1
Names
E2Q-like ubiquitin-conjugating enzyme 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:76980
EC number
2.3.2.23: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

93-161 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0PJN4

Entry ID Method Resolution Chain Position Source
AF-A0PJN4-F1 Predicted AlphaFoldDB

No variants for A0PJN4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0PJN4

No associated diseases with A0PJN4

1 regional properties for A0PJN4

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 1 - 154 IPR000608

Functions

Description
EC Number 2.3.2.23 Aminoacyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.

1 GO annotations of biological process

Name Definition
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.

12 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q32L27 UBE2Q2 Ubiquitin-conjugating enzyme E2 Q2 Bos taurus (Bovine) PR
Q7Z7E8 UBE2Q1 Ubiquitin-conjugating enzyme E2 Q1 Homo sapiens (Human) PR
A1L167 UBE2QL1 Ubiquitin-conjugating enzyme E2Q-like protein 1 Homo sapiens (Human) PR
Q64362 Aktip AKT-interacting protein Mus musculus (Mouse) PR
Q9JJZ4 Ube2j1 Ubiquitin-conjugating enzyme E2 J1 Mus musculus (Mouse) PR
P61087 Ube2k Ubiquitin-conjugating enzyme E2 K Mus musculus (Mouse) PR
Q9CQ37 Ube2t Ubiquitin-conjugating enzyme E2 T Mus musculus (Mouse) PR
Q9D1C1 Ube2c Ubiquitin-conjugating enzyme E2 C Mus musculus (Mouse) PR
P61079 Ube2d3 Ubiquitin-conjugating enzyme E2 D3 Mus musculus (Mouse) PR
P52483 Ube2e3 Ubiquitin-conjugating enzyme E2 E3 Mus musculus (Mouse) PR
Q7TSS2 Ube2q1 Ubiquitin-conjugating enzyme E2 Q1 Mus musculus (Mouse) PR
Q921J4 Ube2s Ubiquitin-conjugating enzyme E2 S Mus musculus (Mouse) SS
10 20 30 40 50 60
MKELQDIARL SDRFISVELV NENLFDWNVK LHQVDKDSVL WQDMKETNTE FILLNLTFPD
70 80 90 100 110 120
NFPFSPPFMR VLSPRLENGY VLDGGAICME LLTPRGWSSA YTVEAVMRQF AASLVKGQGR
130 140 150 160
ICRKAGKSKK SFSRKEAEAT FKSLVKTHEK YGWVTPPVSD G