A0M8S8

PR
Gene name
MET
Protein name
Hepatocyte growth factor receptor
Names
HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
Species
Felis catus (Cat) (Felis silvestris catus)
KEGG Pathway
fca:493669
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

944-1083 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

1222-1249 (Activation loop from InterPro)

Target domain

1079-1346 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for A0M8S8

Entry ID Method Resolution Chain Position Source
AF-A0M8S8-F1 Predicted AlphaFoldDB

No variants for A0M8S8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0M8S8

No associated diseases with A0M8S8

No regional properties for A0M8S8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A0M8S8

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
basal plasma membrane The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
hepatocyte growth factor receptor activity Combining with hepatocyte growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.
identical protein binding Binding to an identical protein or proteins.
protein phosphatase binding Binding to a protein phosphatase.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

22 GO annotations of biological process

Name Definition
branching morphogenesis of an epithelial tube The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
endothelial cell morphogenesis The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.
establishment of skin barrier Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.
liver development The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
negative regulation of guanyl-nucleotide exchange factor activity Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity.
negative regulation of hydrogen peroxide-mediated programmed cell death Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-mediated programmed cell death.
negative regulation of Rho protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
negative regulation of stress fiber assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
negative regulation of thrombin-activated receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron.
pancreas development The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.
phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
positive chemotaxis The directed movement of a motile cell or organism towards a higher concentration of a chemical.
positive regulation of endothelial cell chemotaxis Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
positive regulation of microtubule polymerization Any process that activates or increases the frequency, rate or extent of microtubule polymerization.
positive regulation of protein kinase B signaling Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
semaphorin-plexin signaling pathway The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

42 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q769I5 MET Hepatocyte growth factor receptor Bos taurus (Bovine) PR
Q28889 KIT Mast/stem cell growth factor receptor Kit Felis catus (Cat) (Felis silvestris catus) SS
P13369 CSF1R Macrophage colony-stimulating factor 1 receptor Felis catus (Cat) (Felis silvestris catus) SS
Q75ZY9 MET Hepatocyte growth factor receptor Canis lupus familiaris (Dog) (Canis familiaris) PR
Q2QLA9 MET Hepatocyte growth factor receptor Equus caballus (Horse) PR
P29376 LTK Leukocyte tyrosine kinase receptor Homo sapiens (Human) SS
Q04912 MST1R Macrophage-stimulating protein receptor Homo sapiens (Human) EV
P14616 INSRR Insulin receptor-related protein Homo sapiens (Human) SS
P08922 ROS1 Proto-oncogene tyrosine-protein kinase ROS Homo sapiens (Human) SS
Q9UM73 ALK ALK tyrosine kinase receptor Homo sapiens (Human) EV
O43157 PLXNB1 Plexin-B1 Homo sapiens (Human) EV SS
Q9HCM2 PLXNA4 Plexin-A4 Homo sapiens (Human) SS
O75051 PLXNA2 Plexin-A2 Homo sapiens (Human) SS
P51805 PLXNA3 Plexin-A3 Homo sapiens (Human) SS
Q9UIW2 PLXNA1 Plexin-A1 Homo sapiens (Human) EV SS
O15031 PLXNB2 Plexin-B2 Homo sapiens (Human) SS
Q9ULL4 PLXNB3 Plexin-B3 Homo sapiens (Human) SS
P08581 MET Hepatocyte growth factor receptor Homo sapiens (Human) EV
Q9WTL4 Insrr Insulin receptor-related protein Mus musculus (Mouse) SS
Q62190 Mst1r Macrophage-stimulating protein receptor Mus musculus (Mouse) SS
P97793 Alk ALK tyrosine kinase receptor Mus musculus (Mouse) SS
Q9QY40 Plxnb3 Plexin-B3 Mus musculus (Mouse) SS
P70208 Plxna3 Plexin-A3 Mus musculus (Mouse) EV SS
Q3UH93 Plxnd1 Plexin-D1 Mus musculus (Mouse) SS
P70207 Plxna2 Plexin-A2 Mus musculus (Mouse) SS
B2RXS4 Plxnb2 Plexin-B2 Mus musculus (Mouse) SS
Q8CJH3 Plxnb1 Plexin-B1 Mus musculus (Mouse) SS
Q9QZC2 Plxnc1 Plexin-C1 Mus musculus (Mouse) SS
Q80UG2 Plxna4 Plexin-A4 Mus musculus (Mouse) SS
P70206 Plxna1 Plexin-A1 Mus musculus (Mouse) EV SS
P16056 Met Hepatocyte growth factor receptor Mus musculus (Mouse) PR
Q2QLE0 MET Hepatocyte growth factor receptor Sus scrofa (Pig) PR
Q64716 Insrr Insulin receptor-related protein Rattus norvegicus (Rat) SS
D3ZPX4 Plxna3 Plexin-A3 Rattus norvegicus (Rat) SS
D3ZLH5 Plxnb3 Plexin-B3 Rattus norvegicus (Rat) SS
P97523 Met Hepatocyte growth factor receptor Rattus norvegicus (Rat) PR
Q8I7I5 rol-3 Protein roller-3 Caenorhabditis elegans PR
H2KZU7 svh-2 Tyrosine-protein kinase receptor svh-2 Caenorhabditis elegans SS
F1QVU0 ltk Tyrosine-protein kinase receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
F8W3R9 alk ALK tyrosine kinase receptor Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q6BEA0 plxna4 Plexin-A4 Danio rerio (Zebrafish) (Brachydanio rerio) SS
B0S5N4 plxna3 Plexin A3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MKAPAVLAPG ILVLLFTLVQ KSYGECREAL VKSEMNVNMK YQLPNFTAET PIQNVVLHKH
70 80 90 100 110 120
HIYLGAVNYI YVLNDKDLQK VAEYKTGPVL EHPDCFPCQD CSHKANLSGG VWKDNINMAL
130 140 150 160 170 180
LIDTYYDDQL ISCGSVHRGT CQRHVLPPSN TADILSKVHC MYSPQADEES SHCPDCVVSA
190 200 210 220 230 240
LGTKVLISEK GRFINFFVGN TINSSYLTDH SLHSISVRRL KETQDGFKFL TDQSYIDVLP
250 260 270 280 290 300
EFRDSYPIKY IHAFESNRFI YFLTVQRETL DAQTFHTRII RFCSVDSGLH SYMEMPLECI
310 320 330 340 350 360
LTEKRRKRST REEVFNILQA AYVSKPGAHL AKQIGANLND DILYGVFAQS KPDSAEPMNR
370 380 390 400 410 420
SAVCAFPIKY VNEFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRSDEYRTE
430 440 450 460 470 480
FTTALQRVDL FMGQFNQVLL TSISTFIKGD LTIANLGTSE GRFMQVVVSR SGSSTPHVNF
490 500 510 520 530 540
RLDSHPVSSE AIVEHPLNQN GYTLVVTGKK ITKIPLNGLG CEHFQSCSQC LSAPPFVQCG
550 560 570 580 590 600
WCHDKCVQLE ECPSGTWTQE ICLPTIYEVF PTSAPLEGGT MLTVCGWDFG FRRNNKFDLK
610 620 630 640 650 660
KTRVFLGNES CTLTLSESTT NMLKCTVGPA VNEHFNISII ISNGRGTAQY STFSYVDPVI
670 680 690 700 710 720
TSIFPSYGPK TGGTLLTLTG KYLNSGNSRH ISIGGKTCTL KSVSDSILEC YTPAQTIPTE
730 740 750 760 770 780
FPIKLKIDLA NREMNSFSYQ EDPIVYAIHP TKSFISGGST ITAVGKNLNS VSVLRMVISV
790 800 810 820 830 840
HETRRNFTVA CHHRSNSEII CCTTPSLQQL NLQLPLKTKA FFMLDGIHSK YFDLIYVHNP
850 860 870 880 890 900
VFKPFEKPVM ISIGNENVLE IKGNDIDPEA VKGEVLKVGN KSCETIYSDS EAVLCKVPND
910 920 930 940 950 960
LLKLNNELNI EWKQAVSSTI LGKVIVQPDQ NFTGLIVGVI SISIILLLLL GVFLWLKKRK
970 980 990 1000 1010 1020
QIKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG
1030 1040 1050 1060 1070 1080
SCRQVQYPLT DLSPMLNSGD SDISSPLLQN TVHIDLSALN PELVQAVQHV VIGPSSLIVH
1090 1100 1110 1120 1130 1140
FNEVIGRGHF GCVYHGTLLD SDDKKIHCAV KSLNRITDIG EVSQFLTEGI IMKDFSHPNV
1150 1160 1170 1180 1190 1200
LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK
1210 1220 1230 1240 1250 1260
FVHRDLAARN CMLDEKFTVK VADFGLARDM YDKEYYSVHN KTGAKLPVKW MALESLQTQK
1270 1280 1290 1300 1310 1320
FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITVYLLQG RRLLQPEYCP DPLYEVMLKC
1330 1340 1350 1360 1370 1380
WHPKAELRPS FSELVSRISA IFSTFIGEHY VHVNATYVNV KCVAPYPSLL SSQDNIDGEG
DT