A0JM95
Gene name |
rasgef1a |
Protein name |
Ras-GEF domain-containing family member 1A |
Names |
|
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:734010 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A0JM95
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A0JM95-F1 | Predicted | AlphaFoldDB |
No variants for A0JM95
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A0JM95 | |||||
No associated diseases with A0JM95
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| Ras protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N431 | RASGEF1C | Ras-GEF domain-containing family member 1C | Homo sapiens (Human) | PR |
| Q8N9B8 | RASGEF1A | Ras-GEF domain-containing family member 1A | Homo sapiens (Human) | PR |
| Q9D300 | Rasgef1c | Ras-GEF domain-containing family member 1C | Mus musculus (Mouse) | PR |
| Q28EC1 | rasgef1b | Ras-GEF domain-containing family member 1B | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| A4IJ06 | rasgrp1 | RAS guanyl-releasing protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPQTPIFPSM | LGSTCSGQVQ | PEMGEHCGDP | VYQDGSLVSG | SLEVLIERLV | PTLDYYPDKT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YIFTFLLSAR | IFIHPYEILA | KVGQMCIKQK | QQLESGSEAD | KAKLKSFAAK | IIQLLREWTE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TFPFDFQDER | ARKEMKEIAQ | RITQCDEENG | TIKKSISQMT | QNVLVVLSTR | GQFQEVREKI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RQPVSDKGTI | LKTKPQSAQK | DILSVCSDPL | ILAQQLTTIE | LERLGNIFPE | DLMQIISHMD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLDNHKCRSD | VTKTYNLEAY | DNWFNCLSML | VATEICKVVK | KKQRTRVMEF | FIDVARECFN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IGNFNSMMAI | ISGMNLSPVA | RLKKTWSKVK | TAKFDVLEHH | MDPSSNFCNY | RTALQGATQR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SQSANSSREK | IVIPVFNLFI | KDIFFLHKIH | SNRLPNGHIN | FKKFWEISRQ | IHDFLTWKQV |
| 430 | 440 | 450 | 460 | 470 | |
| ECPYEKDKKI | QTYLLTTPIY | TEEALFLASF | ENEGPDNHME | KDSWKTLRST | LLNRA |