A0A4W3GZU3

SS
Gene name
mdm4
Protein name
Double minute 4 protein
Names
Mdm2-like p53-binding protein, Protein Mdm4, p53-binding protein Mdm4
Species
Callorhinchus milii (Ghost shark)
KEGG Pathway
EC number
Protein Class

Descriptions

MDM4 is a homologous protein that binds to p53 and regulates its activity. Intrinsically disordered region constitute an inhibitory module. It competes with the p53TAD for binding to the NTD of MDM4, thus lowering the affinity of MDMX for p53. Efficient binding of MDM4 to p53 requires a mechanism to relieve the allosteric self-inhibition.

Autoinhibitory domains (AIDs)

184-204 (Tryptohpan-rich segment) SS

Target domain

22-105 (SWIB/MDM2 domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A0A4W3GZU3

Entry ID Method Resolution Chain Position Source
AF-A0A4W3GZU3-F1 Predicted AlphaFoldDB

No variants for A0A4W3GZU3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0A4W3GZU3

No associated diseases with A0A4W3GZU3

2 regional properties for A0A4W3GZU3

Type Name Position InterPro Accession
domain Zinc finger, RanBP2-type 299 - 328 IPR001876
domain SWIB/MDM2 domain 22 - 105 IPR003121

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTTASTSNPY PSSDILCGNS TEKIRPKPLL LNLLHEAGAS GEIFTLKEVM HYLGQYIMLK
70 80 90 100 110 120
QLYDKQQQHI VYCGNDPLGK VFGVESFSVK VPSQLYEMLS RNLIALNFHD AAQTRTLVKE
130 140 150 160 170 180
TNCLPLREEH LKCLTGETSE GETVCIVPNS ATSHLKRKNS ESDDLDADDQ PELQSKRQRS
190 200 210 220 230 240
ESVSDHWDAA GLPWWFIKSL QSNYGSRKSG STDIHSNQDI DTAIVSDSTD DLWFLNEPDH
250 260 270 280 290 300
DQANVEIKEG AIHPKEIRDQ EEEKEEDKNT DPKEVIEVTI YEAGEGLSCS GHATDPEISD
310 320 330 340 350 360
KSWKCTKCGE DNPSQKQYCL QCWALRGGWH LKCPKLTRST SGPSIAIAEN EPYEGIDVPD
370 380 390 400 410 420
SKRSISEPVI QIKDLKCKEM GIISTPCASS ESLDSLSQPS TSSLWRSRED LESVGKEAKT
430 440 450 460 470 480
VKRKCEDSLQ SRRQRLGPCL ICGVRPRTGN IIHRKMGHLV ACYTCAKSLY KRKMPCPVCV
490
QPIIMVIQTF IG