Descriptions
FoxO3b is predicted to be a transcription factor. This protein possesses intrinsically disordered regions (IDRs) with large negative charge, some of which involve a consecutive sequence of aspartate (D) or glutamate (E) residues, known as D/E repeats. These D/E repeats can cause autoinhibition through intramolecular electrostatic interaction with HMG boxes and modulate binding to DNA. This autoinhibited state can transition into the uninhibited complex with DNA through an electrostatically driven induced-fit process, which accelerates the target DNA search kinetics in the presence of non-functional high-affinity ligands ('decoys').
Autoinhibitory domains (AIDs)
Target domain |
240-290 (DNA-binding domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for A0A2Z4LIS9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A0A2Z4LIS9-F1 | Predicted | AlphaFoldDB |
1 variants for A0A2Z4LIS9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| TCGA novel | 47 | A>P | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
No associated diseases with A0A2Z4LIS9
No regional properties for A0A2Z4LIS9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A0A2Z4LIS9 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| METDLAEMPE | KGVLSSQDSP | HFQEKSTEEG | EVAALRLTAR | SQAAAAAAAP | GSRSLRGVHV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PPPLHPAPAR | EESARTPAAA | GRAAKMAEAP | ASPAPLSPLE | VELDPEFEPQ | SRPRSCTWPL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QRPELQASPA | KPSGETAADS | MIPEEEDDED | DEDGGGRAGS | AMAIGGGGGS | RTLVSGLLLE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DSVRVLAPGG | QDPGSGPATA | AGGLSGGTQA | LLQPQQPLPP | PQPGAAGGSG | QPRKCSSRRN |
| 250 | 260 | 270 | 280 | ||
| AWGNLSYADL | ITRAIESSPD | RRLTLSQIYE | WMVSCVPYFK | DKGNSNSSAG |