Descriptions
Bacterial gasdermin (bGSDM) is a precursor of a pore-forming protein involved in defense against bacteriophages. Upon proteolytic cleavage within an interdomain linker, the pore-forming N-terminal domain is released from the inhibitory C-terminal domain. Subsequent cysteine palmitoylation strengthens membrane interactions and enhances pore formation. The size and architecture of these pores are highly diverse, showing structural variability among different bacterial species.
Autoinhibitory domains (AIDs)
Target domain |
1-237 (Pore-forming N-terminal domain) |
Relief mechanism |
Cleavage |
Assay |
Deletion assay, Structural analysis, Mutagenesis experiment |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for A0A2T4VDM4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7N51 | X-ray | 167 A | A | 2-266 | PDB |
| 8SL0 | EM | 330 A | A | 2-233 | PDB |
| AF-A0A2T4VDM4-F1 | Predicted | AlphaFoldDB |
No variants for A0A2T4VDM4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A0A2T4VDM4 | |||||
No associated diseases with A0A2T4VDM4
No regional properties for A0A2T4VDM4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for A0A2T4VDM4 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| defense response to virus | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLCSDPAIT | YLKRLGYNVV | RLPREGIQPL | HLLGQQRGTV | EYLGSLEKLI | TQPPSEPPAI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TRDQAAAGIN | GQKTENLSFS | IGINILKSVL | AQFGAGAGIE | AQYNQARKVR | FEFSNVLADS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VEPLAVGQFL | KMAEVDADNP | VLKQYVLGNG | RLYVITQVIK | SNEFTVAAEK | SGGGSIQLDV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PEIQKVVGGK | LKVEASVSSQ | STVTYKGEKQ | LVFGFKCFEI | GVKNGEITLF | ASQPGAIAMA |
| 250 | 260 | ||||
| LDAAGGVMPS | DSALLDEGGL | LDLEGF |