A0A2I2U1K8

SS
Gene name
ITSN1
Protein name
Intersectin 1
Names
Species
Felis catus (Cat) (Felis silvestris catus)
KEGG Pathway
EC number
Protein Class

Descriptions

Autoinhibitory domains (AIDs)

721-740 (N-terminal linker of SH3A) SS

Target domain

741-803 (SH3A domain)

Relief mechanism

Assay

804-840 (C-terminal linker of SH3A) SS

Target domain

741-803 (SH3A domain)

Relief mechanism

PTM

Assay

1158-1210 (SH3E domain) SS

Target domain

1237-1423 (DH domain)

Relief mechanism

Partner binding, Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for A0A2I2U1K8

Entry ID Method Resolution Chain Position Source

No variants for A0A2I2U1K8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0A2I2U1K8

No associated diseases with A0A2I2U1K8

16 regional properties for A0A2I2U1K8

Type Name Position InterPro Accession
domain C2 domain 1579 - 1695 IPR000008
domain Dbl homology (DH) domain 1237 - 1423 IPR000219
domain EH domain 14 - 108 IPR000261-1
domain EH domain 214 - 310 IPR000261-2
conserved_site Guanine-nucleotide dissociation stimulator, CDC24, conserved site 1371 - 1396 IPR001331
domain SH3 domain 740 - 806 IPR001452-1
domain SH3 domain 913 - 971 IPR001452-2
domain SH3 domain 1002 - 1060 IPR001452-3
domain SH3 domain 1074 - 1138 IPR001452-4
domain SH3 domain 1155 - 1214 IPR001452-5
domain Pleckstrin homology domain 1440 - 1593 IPR001849
domain EF-hand domain 53 - 88 IPR002048-1
domain EF-hand domain 254 - 289 IPR002048-2
binding_site EF-Hand 1, calcium-binding site 66 - 78 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 267 - 279 IPR018247-2
domain Intersectin-1, AP2 binding region 803 - 917 IPR032140

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
clathrin-coated pit A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular vesicle Any vesicle that is part of the intracellular region.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.

4 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
molecular adaptor activity The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
proline-rich region binding Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.

4 GO annotations of biological process

Name Definition
clathrin-dependent synaptic vesicle endocytosis Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds.
endosomal transport The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
E1BKY4 ITSN1 Intersectin 1 Bos taurus (Bovine) SS
A0A2I3T257 ITSN1 Intersectin 1 Pan troglodytes (Chimpanzee) SS
Q15811 ITSN1 Intersectin-1 Homo sapiens (Human) EV SS
Q9Z0R4 Itsn1 Intersectin-1 Mus musculus (Mouse) EV
Q9WVE9 Itsn1 Intersectin-1 Rattus norvegicus (Rat) SS
10 20 30 40 50 60
MAQFPTPFGG SLDIWAITVE ERAKHDQQFH SLKPISGFIT GDQARNFFFQ SGLPQPVLAQ
70 80 90 100 110 120
IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSTLPP VMKQQPVAIS SAPAFGIGGI
130 140 150 160 170 180
ASMPPLTAVA PVPMGSIPVV GMSPPLVSSV PTAAVPPLAN GAPPVIQPLP AFAHPAATLP
190 200 210 220 230 240
KSSSFSRSGP GSQLNTKLQK AQSFDVASAP PAAEWAVPQS SRLKYRQLFN SHDKTMSGHL
250 260 270 280 290 300
TGPQARTILM QSSLPQAQLA SIWNLSDIDQ DGKLTAEEFI LAMHLIDVAM SGQPLPPVLP
310 320 330 340 350 360
PEYIPPSFRR VRSGSGISVI SSTAVDQRLP EEPVLEDEQQ QLEKKLPVTF EDKKRENFER
370 380 390 400 410 420
GNLELEKRRQ ALLEQQRKEQ ERLAQLERAE QERKERERQE QERKRQLELE KQLEKQRELE
430 440 450 460 470 480
RQREEERRKE IERREAAKRE LERQRQLEWE RNRRQELLNQ RNKEQEDIVV LKAKKKTLEF
490 500 510 520 530 540
ELEALNDKKH QLEGKLQDIR CRLTTQRQEI ESTNKSRELR IAEITHLQQQ LQEAQQMLGR
550 560 570 580 590 600
LIPEKQILND QLKQVQQNSL HRDSLLTLKR ALEAKEVARQ QLRDQLDEVE KETRSKLQEI
610 620 630 640 650 660
DIFNNQLKEL REIHNKQQLQ KQKSIEAERL KQKEQERKII ELEKQKEEAQ RRAQERDRLW
670 680 690 700 710 720
TEHTQPDNEQ QRPRKIHEDE KLRREESVKK KDGEEKGRPD TQDKMSRLFH QHQEPAKPAV
730 740 750 760 770 780
QAPWSTTEKG PLTISAQENV KVVYYRALYP FESRSHDEIT IQPGDIVMVK GEWVDESQTG
790 800 810 820 830 840
EPGWLGGELK GKTGWFPANY AEKIPENEVP APVKPGPDTT STPAPKLAVR ETPAPVAVTA
850 860 870 880 890 900
PEPSTTPNNW ADFSSTWPTS TNEKPETDNW DAWAAQPSLT VPSAGQLRQR SAFTPATATG
910 920 930 940 950 960
SSPSPVLGQG EKVEGLQAQA LYPWRAKKDN HLNFNKNDVI TVLEQQDMWW FGEVQGQKGW
970 980 990 1000 1010 1020
FPKSYVKLIS GPIRKSTSID SGSSESPASL KRVASPAAKP AVSGEEFIAM YTYESSEQGD
1030 1040 1050 1060 1070 1080
LTFQQGDVIL VTKKDGDWWT GTVGDKSGVF PSNYVRLKDS EGSGTAGKTG SLGKKPEIAQ
1090 1100 1110 1120 1130 1140
VIACYTATGP EQLTLAPGQL ILIRKKNPGG WWEGELQARG KKRQIGWFPA NYVKLLSPGT
1150 1160 1170 1180 1190 1200
SKITPTEPPK PTALPAVCQV IGMYDYIAQN DDELAFNKGQ IINVLNKEDP DWWKGEVNGQ
1210 1220 1230 1240 1250 1260
VGLFPSNYVK LTTDMDPSQQ WCSDLHLLDM LTPTERKRQG YIHELIVTEE NYVNDLQLVT
1270 1280 1290 1300 1310 1320
EIFQKPLMES ELLTEKEGAM IFVNWKELIM CNIKLLKALR VRKKMSGEKM PVKMVGDILT
1330 1340 1350 1360 1370 1380
AQLPHMQPYI RFCSCQLNGA ALIQQKTDEA PDFKEFVKRL AMDPRCKGMP LSSFILKPMQ
1390 1400 1410 1420 1430 1440
RVTRYPLIIK NILENTPENH PDHSHLKHAL EKAEELCSQV NEGVREKENS DRLEWIQGHV
1450 1460 1470 1480 1490 1500
QCEGLSEQLV FNSVTNCLGP RKFLHSGKLY KAKSNKELYG FLFNDFLLLT QIIKPLGSSG
1510 1520 1530 1540 1550 1560
TDKVFSPKSN LQYKMYKTPI FLNEVLVKLP TDPSGDEPIF HISHIDRVYT LRAESINERT
1570 1580 1590 1600 1610 1620
AWVQKIKAAS ELYIETEKKK REKAYLVRSQ RATGIGRLMV NVVEGIELKP CRSHGKSNPY
1630 1640 1650 1660 1670 1680
CEVTMGSQCH ITKTIQDTLN PKWNSNCQFF IKDLEQEVLC ITVFERDQFS PDDFLGRTEI
1690 1700 1710 1720
RVADIKKDQG SKGPVTKCLL LHEVPTGEIV VRLDLQLFDE P