Descriptions
Diaphanous-related formins (DRFs), such as DAAM1 and mDia1, play central roles in actin dynamics through assembling linear actin filaments. The amino-terminal diaphanous inhibitory domain (DID) and the carboxyl-terminal diaphanous autoinhibitory domain (DAD) segment form an intramolecular interaction to restrain the actin assembly activity of FH1-FH2 domains. This autoinhibition is disrupted by Rho GTPase that is able to bind to the GTPase-binding domain (GBD) near DID domain.
Autoinhibitory domains (AIDs)
Target domain |
36-473 (DID domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A0A1D5P556
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A0A1D5P556-F1 | Predicted | AlphaFoldDB |
No variants for A0A1D5P556
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A0A1D5P556 | |||||
No associated diseases with A0A1D5P556
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| small GTPase binding | Binding to a small monomeric GTPase. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| dorsal spinal cord development | The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. |
| negative regulation of oligodendrocyte differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation. |
| positive regulation of canonical Wnt signaling pathway | Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| regulation of canonical Wnt signaling pathway | Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| regulation of non-canonical Wnt signaling pathway | Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O95466 | FMNL1 | Formin-like protein 1 | Homo sapiens (Human) | SS |
| Q27J81 | INF2 | Inverted formin-2 | Homo sapiens (Human) | EV |
| Q9Y4D1 | DAAM1 | Disheveled-associated activator of morphogenesis 1 | Homo sapiens (Human) | EV |
| Q86T65 | DAAM2 | Disheveled-associated activator of morphogenesis 2 | Homo sapiens (Human) | SS |
| Q8BPM0 | Daam1 | Disheveled-associated activator of morphogenesis 1 | Mus musculus (Mouse) | PR |
| Q0GNC1 | Inf2 | Inverted formin-2 | Mus musculus (Mouse) | SS |
| Q0QWG9 | Grid2ip | Delphilin | Mus musculus (Mouse) | PR |
| Q80U19 | Daam2 | Disheveled-associated activator of morphogenesis 2 | Mus musculus (Mouse) | SS |
| Q9C7S1 | FH12 | Formin-like protein 12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LH02 | FH17 | Formin-like protein 17 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P0C5K4 | FH21A | Putative formin-like protein 21a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FF14 | FH19 | Formin-like protein 19 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAPRKRNRHA | LGFLCCFGGS | DLPEINLKDN | NPLQFLDFTV | PIPPTEELNA | RFSELVDELD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LTDKNREAMF | ALPPEKKWQI | YCSKKKEQED | PNKLATSWPD | YYIDRINSMA | AMQTLYAFDE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EETEMKNKIV | EDLKTALRTQ | PMRFVMRFIE | LDGLSCLLNF | LKSMDYETSE | SRIHTSVIGC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IKALMNNSQG | RAHVLAHPES | INIISQSLRT | ENIKTKIAVL | EILGAVCLVP | DGHKKVLQAM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LHYQVYAAER | TRFQTLLNEL | DRSMGRYRDE | VNLKTAIMSF | INAVLNAGAG | EDNLEFRLHL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RYEFLMLGIQ | PVIDKLREHE | NATLDRHLDF | FEMVRNEDDL | ELAKRFDLIH | IDTKSASQMF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ELIKKRLKHT | DAYPYLLSIL | QHCLQMPYKR | NGGNFQQWQL | LDRILQQIVL | QDERGDDPDI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| APLENFNVKN | IIKMLVNENE | VKQWRDQAEK | FRKDHAELMS | KLEKKERECE | TKTQEKDEMM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KTLNKMKDKL | QKESLELRQA | RDQMNDLVAQ | LNEYSQGGSI | SFPAPPPPPP | GGPLALSSAL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SSALTSENLP | PLPPPLPFSS | CPPPPAPPPP | PGGPPPPPGA | PPFFSLGVPP | PSTTTFSSAG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TSLKKKSIPQ | PSHPLKSFNW | AKLSEERIHG | TIWNEIDDLK | AFKVLDLEDF | EKMFSAYQRH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QKEMGSTEDL | YLSTRKVKEL | SVIDGRRAQN | CVILLSKLKL | SNEEIRQAIL | KMDEQEDLAK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DMLEQLLKFV | PEKSDTDLLE | EHKHEIERMA | RADRFLFEMS | RIDHYQQRLQ | ALFFKKKFPE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RLAEAKPKVE | AILLASKELI | RSKRLRQLLE | VVLAFGNYMN | KGQRGSAYGF | KVSSLNKIAD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TKSSIDRNIT | LLHYLIMIFE | KNYPDILDIQ | TELQHLPEAA | KVNLVELEKE | VNNIKTGLKA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VEAELDYQKR | RIRESGDRFV | PVMSDFITVA | SFSFSELEDL | LNDARDKYAK | ALKHFGENEG |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KMQPDEFFGI | FDTFLQSFAE | AKQDLENMRK | KKEEEERRAR | MEAMLKEQRE | KERRQKKAKA |
| 1030 | 1040 | 1050 | 1060 | 1070 | |
| GSISEETGEF | DDLVSALRSG | EVFDKDLSKL | KRNRKRSGNQ | GLETSRERVV | TKLNY |