A0A0R4I961

EV
Gene name
ECP_4655
Protein name
FimH protein
Names
Species
Escherichia coli F18+
KEGG Pathway
EC number
Protein Class
FIMBRIAL SUBUNIT ELFA-RELATED (PTHR33420)

Descriptions

The Escherichia coli fimbrial adhesive protein, FimH, mediates shear-dependent binding to mannosylated surfaces via force-enhanced allosteric catch bonds. The anchoring (pilin) domain (155-279) of FimH interacts with the mannose-binding (lectin) domain, causing a twist in the b sandwich fold of the mannose-binding domain. This loosens the mannose-binding pocket on the opposite end of the lectin domain, resulting in an inactive low-affinity state of the adhesin.

Autoinhibitory domains (AIDs)

155-279 (Pilin domain) EV

Target domain

1-158 (Mannose-binding domain)

Relief mechanism

Others

Assay

Mutagenesis experiment, Structural analysis

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for A0A0R4I961

Entry ID Method Resolution Chain Position Source
3JWN X-ray 269 A H/N 1-279 PDB
6GTV X-ray 210 A A/C 1-279 PDB
6GTW X-ray 250 A A/B/C/D 1-159 PDB
6GTZ X-ray 172 A A/C 1-279 PDB
6GU0 X-ray 250 A A 1-279 PDB
AF-A0A0R4I961-F1 Predicted AlphaFoldDB

No variants for A0A0R4I961

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0A0R4I961

No associated diseases with A0A0R4I961

2 regional properties for A0A0R4I961

Type Name Position InterPro Accession
domain Fimbrial-type adhesion domain 154 - 279 IPR000259
domain FimH, mannose-binding domain 1 - 158 IPR015243

Functions

Description
EC Number
Subcellular Localization
  • Fimbrium
PANTHER Family PTHR33420 FIMBRIAL SUBUNIT ELFA-RELATED
PANTHER Subfamily PTHR33420:SF11 TYPE 1 FIMBRIN D-MANNOSE SPECIFIC ADHESIN
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
pilus A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
FACKTANGTA IPIGGGSANV YVNLAPAVNV GQNLVVDLST QIFCHNDYPE TITDYVTLQR
70 80 90 100 110 120
GSAYGGVLSS FSGTVKYNGS SYPFPTTSET PRVVYNSRTD KPWPVALYLT PVSSAGGVAI
130 140 150 160 170 180
KAGSLIAVLI LRQTNNYNSD DFQFVWNIYA NNDVVVPTGG CDVSARDVTV TLPDYPGSVP
190 200 210 220 230 240
IPLTVYCAKS QNLGYYLSGT TADAGNSIFT NTASFSPAQG VGVQLTRNGT IIPANNTVSL
250 260 270
GAVGTSAVSL GLTANYARTG GQVTAGNVQS IIGVTFVYQ