A0A098ZQ63

SS
Gene name
mta (AZJ28_05800, AZK02_11115, ERS021218_02137, ERS096071_00595, GM539_08810, SAMEA104154639_01595)
Protein name
MerR family transcriptional regulator
Names
Species
Streptococcus pneumoniae
KEGG Pathway
EC number
Protein Class

Descriptions

The Mta (MerR family transcriptional regulator) belongs to the TipA class of transcription factors, which constitutes minimal autoregulated multidrug resistance (MDR) against diverse antibiotics. Autoinhibitory mechanism in SkgA has been identified by structural analysis. Due to the structural similarity of Mta to SkgA, Mta could also possess an autoinhibitory mechanism. In the case of SkgA, upon binding of antibiotics to the TipAS domain within SkgA, SkgA is able to induce transcription of genes involved in multidrug resistance such as efflux pumps and antibiotics sequester proteins. The autoinhibition mechanism involves the a6–a7 region of the TipAS domain, which, in the unliganded state, interacts with the DNA-binding domain to stabilize the dimeric interface and hinder promoter DNA binding. This interaction prevents transcriptional activation by sterically blocking DNA access to the DNA-binding domain.

Autoinhibitory domains (AIDs)

114-133 (alpha6–alpha7 region within TipAS domain) SS

Target domain

3-73 (MerR-type HTH domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for A0A098ZQ63

Entry ID Method Resolution Chain Position Source

No variants for A0A098ZQ63

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A0A098ZQ63

No associated diseases with A0A098ZQ63

4 regional properties for A0A098ZQ63

Type Name Position InterPro Accession
binding_site IQ motif, EF-hand binding site 783 - 805 IPR000048
domain Myosin head, motor domain 80 - 782 IPR001609
domain Myosin tail 849 - 1926 IPR002928
domain Myosin, N-terminal, SH3-like 33 - 82 IPR004009

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYHIKEAAQL SGVSVKTLHH YDKIGLLVPL KSENGYRTYS QEDLERLQVI LYYKYLGFSL
70 80 90 100 110 120
EKIAELLKEE RTDLLPHLTR QLDYLTRERQ HLDTLISTLQ KTIQEQKGER KMTIEEKFTG
130 140 150 160 170 180
FSYQDNQKYH QEAVEKYGQE VMGQALERQK GHEDEATAAF NQVFQTLAQN LQVGLPATAT
190 200 210 220 230 240
ENQEQAAKLL QAIRTYGFDC SIEVFGHIGK GYVYNPEFKE NIDKFGSGTA QYTSDAIAAY
VQTNAEKIG