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autoinhibited proteins
a database of autoinhibited proteins
Autoinhibited Proteins
Autoinhibition is a mechanism through which cellular proteins function via self-regulation by transient intramolecular interaction between different parts of the protein.
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Recent papers of autoinhibited proteins
- Hou Y et al. (2023) "How a single mutation alters the protein structure: a simulation investigation on protein tyrosine phosphatase SHP2", RSC advances, 13, 4263-4274
- Rangarajan ES et al. (2023) "Distinct inter-domain interactions of dimeric versus monomeric α-catenin link cell junctions to filaments", Communications biology, 6, 276
- Huang N et al. (2023) "N-glycosylation on Asn-57 is required for the correct HAI-2 protein folding and protease inhibitory activity", Glycobiology, 33, 203-214
- Qiu R et al. (2023) "Kinesin-1 autoinhibition facilitates the initiation of dynein cargo transport", The Journal of cell biology, 222,
- Legan ER et al. (2023) "Type 2B von Willebrand disease mutations differentially perturb autoinhibition of the A1 domain", Blood, 141, 1221-1232
- Orth-He EL et al. (2023) "Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation", Cell reports, 42, 111965
- Wang Q et al. (2023) "The NLRP1 and CARD8 inflammasomes detect reductive stress", Cell reports, 42, 111966
- Reimer JM et al. (2023) "Structures of human dynein in complex with the lissencephaly 1 protein, LIS1", eLife, 12,
- Wong DCP et al. (2023) "The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration", Molecular biology of the cell, 34, ar13
Version: 2.1
Release: 2024_06
AIDs: 45,913
Cite us
Autoinhibited Protein Database: a curated database of autoinhibitory domains and their autoinhibition mechanisms
Daeahn Cho, Hyang-Mi Lee, Ji Ah Kim, Jae Gwang Song, Su-hee Hwang, Bomi Lee, Jinsil Park, Kha Mong Tran, Jiwon Kim, Phuong Ngoc Lam Vo, Jooeun Bae, Teerapat Pimt, Kangseok Lee, Jörg Gsponer*, Hyung Wook Kim*, and Dokyun Na* (2024).
Database : The Journal of Biological Databases and Curation, 2024, baae085.